A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found within genes and introns, with a large minority being close to...

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Bibliographic Details
Main Authors: Kamil Pabis, Diogo Barardo, Olga Sirbu, Kumar Selvarajoo, Jan Gruber, Brian K Kennedy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
aging
transposon expression
senescense
intron retention
transcriptional readthrough
Online Access:https://elifesciences.org/articles/87811

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