PNPLA5-knockout rats induced by CRISPR/Cas9 exhibit abnormal bleeding and lipid level

PNPLA5-knockout rats induced by CRISPR/Cas9 exhibit abnormal bleeding and lipid level

Patatin-like phospholipase domain containing 5 (PNPLA5) is a neotype neutral lipase with dual activity of anabolism and catabolism in vitro and in vivo, which has a low mRNA expression level in humans and mice. PNPLA5, which is localized to lipid droplets and required for efficient autophagy by opti...

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Bibliographic Details
Main Authors: Yang LIU, Qian GAO, Xue ZHANG, Lei HUANG, Kui XU, Yan-qing HU, Lan LIU, Yu-lian MU, Kui LI
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Integrative Agriculture
Subjects:
PNPLA5
CRISPR/Cas9 system
PNPLA5-knockout SD rats
abnormal bleeding
lipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2095311916614375

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