<it>SETBP1</it> and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
<p>Abstract</p> <p>The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined. The involvement of microRNA (miRNA) is actually helping to shed light on an important issue in the occurrence of myeloprol...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-08-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2148/12/96 |
| _version_ | 1818346886969425920 |
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| author | Albano Francesco Anelli Luisa Zagaria Antonella Coccaro Nicoletta Casieri Paola Minervini Angela Specchia Giorgina |
| author_facet | Albano Francesco Anelli Luisa Zagaria Antonella Coccaro Nicoletta Casieri Paola Minervini Angela Specchia Giorgina |
| author_sort | Albano Francesco |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined. The involvement of microRNA (miRNA) is actually helping to shed light on an important issue in the occurrence of myeloproliferative neoplasms (MPNs). However, the role of intronic miRNA, derived from the intron regions of gene transcripts, has never been reported in MPNs. In this study, we describe a PMF case evolved to AML with a t(12;18)(p13;q12) rearrangement showing the downregulation of the intronic miR_4319 and the overexpression of its host gene, SET binding protein (<it>SETBP1</it>). A possible molecular mechanism regulating the PMF progression to AML is discussed.</p> |
| first_indexed | 2024-12-13T17:25:24Z |
| format | Article |
| id | doaj.art-2b59b4e321384632862f6e18aeb43479 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-13T17:25:24Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-2b59b4e321384632862f6e18aeb434792022-12-21T23:37:12ZengBMCJournal of Hematology & Oncology1756-87222012-08-01514810.1186/1756-8722-5-48<it>SETBP1</it> and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemiaAlbano FrancescoAnelli LuisaZagaria AntonellaCoccaro NicolettaCasieri PaolaMinervini AngelaSpecchia Giorgina<p>Abstract</p> <p>The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined. The involvement of microRNA (miRNA) is actually helping to shed light on an important issue in the occurrence of myeloproliferative neoplasms (MPNs). However, the role of intronic miRNA, derived from the intron regions of gene transcripts, has never been reported in MPNs. In this study, we describe a PMF case evolved to AML with a t(12;18)(p13;q12) rearrangement showing the downregulation of the intronic miR_4319 and the overexpression of its host gene, SET binding protein (<it>SETBP1</it>). A possible molecular mechanism regulating the PMF progression to AML is discussed.</p>http://www.biomedcentral.com/1471-2148/12/96Primary myelofibrosis progressionT(12;18)(p13;q12) translocation<it>SETBP1</it> and miR_4319 dysregulationIntronic miRNA |
| spellingShingle | Albano Francesco Anelli Luisa Zagaria Antonella Coccaro Nicoletta Casieri Paola Minervini Angela Specchia Giorgina <it>SETBP1</it> and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia Journal of Hematology & Oncology Primary myelofibrosis progression T(12;18)(p13;q12) translocation <it>SETBP1</it> and miR_4319 dysregulation Intronic miRNA |
| title | <it>SETBP1</it> and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia |
| title_full | <it>SETBP1</it> and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia |
| title_fullStr | <it>SETBP1</it> and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia |
| title_full_unstemmed | <it>SETBP1</it> and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia |
| title_short | <it>SETBP1</it> and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia |
| title_sort | it setbp1 it and mir 4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia |
| topic | Primary myelofibrosis progression T(12;18)(p13;q12) translocation <it>SETBP1</it> and miR_4319 dysregulation Intronic miRNA |
| url | http://www.biomedcentral.com/1471-2148/12/96 |
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