A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature
Abstract Background Breast cancer is one of the most common causes of brain metastases. However, the presence of isolated central nervous system (CNS) metastatic disease early in the course of disease relapse is a rare event in cases of hormone receptor positive, human epidermal growth factor recept...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-020-02615-2 |
| _version_ | 1818725640394768384 |
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| author | Sandipkumar H Patel Yoshihito David Saito Zaibo Li Bhuvaneswari Ramaswamy Andrew Stiff Mahmoud Kassem Robert Wesolowski |
| author_facet | Sandipkumar H Patel Yoshihito David Saito Zaibo Li Bhuvaneswari Ramaswamy Andrew Stiff Mahmoud Kassem Robert Wesolowski |
| author_sort | Sandipkumar H Patel |
| collection | DOAJ |
| description | Abstract Background Breast cancer is one of the most common causes of brain metastases. However, the presence of isolated central nervous system (CNS) metastatic disease early in the course of disease relapse is a rare event in cases of hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer. Case presentation We summarize the clinical course of a pre-menopausal, 39-year old Caucasian female with history of operable, hormone receptor positive, HER2 negative breast cancer who was initially treated with curative-intend therapy but who unfortunately developed solitary metastatic lesion in the left thalamus. A biopsy of the lesion confirmed the presence of hormone receptor positive, HER2 negative metastatic breast cancer. Patient’s CNS metastases continued to progress without any evidence of metastatic disease outside of the central nervous system and she eventually passed away about 5 years after the date of her initial diagnosis and 18 months following the diagnosis with brain metastasis. Conclusion Based on our case, although rare, patients with treated, operable, hormone receptor positive, HER2 negative breast cancer can present with solitary brain metastasis as the only sign of disease recurrence. |
| first_indexed | 2024-12-17T21:45:31Z |
| format | Article |
| id | doaj.art-2b5a799910ad431993942e8acd3508fc |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-17T21:45:31Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-2b5a799910ad431993942e8acd3508fc2022-12-21T21:31:28ZengBMCJournal of Medical Case Reports1752-19472021-01-011511610.1186/s13256-020-02615-2A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literatureSandipkumar H Patel0Yoshihito David Saito1Zaibo Li2Bhuvaneswari Ramaswamy3Andrew Stiff4Mahmoud Kassem5Robert Wesolowski6Division of Medical Oncology, The Ohio State University Wexner Medical CenterThe Queen’s Medical Center - West Oahu Queen’s Cancer Center - West Oahu, Sullivan Care CenterDepartment of Pathology, The Ohio State UniversityDivision of Medical Oncology, The Ohio State University Wexner Medical CenterThe Ohio State University Comprehensive Cancer Center, The Ohio State UniversityDivision of Medical Oncology, The Ohio State University Wexner Medical CenterDivision of Medical Oncology, The Ohio State University Wexner Medical CenterAbstract Background Breast cancer is one of the most common causes of brain metastases. However, the presence of isolated central nervous system (CNS) metastatic disease early in the course of disease relapse is a rare event in cases of hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer. Case presentation We summarize the clinical course of a pre-menopausal, 39-year old Caucasian female with history of operable, hormone receptor positive, HER2 negative breast cancer who was initially treated with curative-intend therapy but who unfortunately developed solitary metastatic lesion in the left thalamus. A biopsy of the lesion confirmed the presence of hormone receptor positive, HER2 negative metastatic breast cancer. Patient’s CNS metastases continued to progress without any evidence of metastatic disease outside of the central nervous system and she eventually passed away about 5 years after the date of her initial diagnosis and 18 months following the diagnosis with brain metastasis. Conclusion Based on our case, although rare, patients with treated, operable, hormone receptor positive, HER2 negative breast cancer can present with solitary brain metastasis as the only sign of disease recurrence.https://doi.org/10.1186/s13256-020-02615-2Breast cancerBrain metastasesChemotherapyHER2Hormone receptors |
| spellingShingle | Sandipkumar H Patel Yoshihito David Saito Zaibo Li Bhuvaneswari Ramaswamy Andrew Stiff Mahmoud Kassem Robert Wesolowski A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature Journal of Medical Case Reports Breast cancer Brain metastases Chemotherapy HER2 Hormone receptors |
| title | A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature |
| title_full | A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature |
| title_fullStr | A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature |
| title_full_unstemmed | A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature |
| title_short | A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature |
| title_sort | solitary brain metastasis as the only site of recurrence of hr positive her2 negative breast cancer a case report and review of the literature |
| topic | Breast cancer Brain metastases Chemotherapy HER2 Hormone receptors |
| url | https://doi.org/10.1186/s13256-020-02615-2 |
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