Prevalence of Asymptomatic HIV-associated Neurocognitive Disorder in a Tertiary Care Hospital in South India: A Single Centered Observational Study
Introduction: Asymptomatic HIV-associated neurocognitive disorder (HAND) is associated with increased morbidity, and it often goes undetected in outpatient clinics due to the lack of awareness and time constraints for a detailed assessment in such cases. We assessed the prevalence of HAND by using M...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Turkish |
| Published: |
Galenos Yayinevi
2023-07-01
|
| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| Subjects: | |
| Online Access: | https://mjima.org/text.php?&id=377 |
| _version_ | 1797777687667802112 |
|---|---|
| author | Nivedhithaa SELVARAJ Yoganathan CHIDAMBARAM C. P. Clement Jenil DHAS Abilash NEKKANTI Petchiappan VELAMMAL Bhargavi KUMAR Murali ALAGESAN |
| author_facet | Nivedhithaa SELVARAJ Yoganathan CHIDAMBARAM C. P. Clement Jenil DHAS Abilash NEKKANTI Petchiappan VELAMMAL Bhargavi KUMAR Murali ALAGESAN |
| author_sort | Nivedhithaa SELVARAJ |
| collection | DOAJ |
| description | Introduction: Asymptomatic HIV-associated neurocognitive disorder (HAND) is associated with increased morbidity, and it often goes undetected in outpatient clinics due to the lack of awareness and time constraints for a detailed assessment in such cases. We assessed the prevalence of HAND by using Montreal Cognitive Assessment (MoCA) test and evaluated the association between the severity of HIV using CD4 count and cognitive impairment.
Materials and Methods: This cross-sectional study enrolled 103 patients (age: 20-80 years) living with HIV who were sampled through convenient sampling technique. Demographic details such as the age, sex, and education, and the current CD4 count were recorded and the patients were accordingly assigned to the following groups: A (>500 cells/µl), B (200-499 cells/µl), and C (<200 cells/µl) with reference to the Center for Disease Control and Prevention guidelines for the distribution of CD4+T cells in HIV. Cognitive impairment in patients was screened using MoCA with a cut-off score of <26. Data was defined using descriptive statistics, between-group comparison was performed using ANOVA and chi-square tests, and the association between the MoCA score and CD4 count was assessed by using Spearman’s correlation coefficient. P<05 was considered to indicate statistical significance.
Results: HIV-associated neurocognitive disorder was prevalent among 73.8% of the sample population, where 8.7% had severe, 18.4% had moderate, and 46.6% had mild impairment. Based on the CD4 count, 10.6% were categorized into group A, 39.8% into group B, and 49.5% into group C. The association of the MoCA score with CD4 count was found to be moderately positive and statistically significant (r2=0.644, p=0.000).
Conclusion: A high prevalence of HAND, specifically an asymptomatic form, was observed among patients living with HIV. The MoCA score was significantly associated with CD4 count, albeit moderately positive. |
| first_indexed | 2024-03-12T23:07:22Z |
| format | Article |
| id | doaj.art-2b5aa88d0b4248e8b0a1417ce2651f72 |
| institution | Directory Open Access Journal |
| issn | 2147-673X |
| language | Turkish |
| last_indexed | 2024-03-12T23:07:22Z |
| publishDate | 2023-07-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj.art-2b5aa88d0b4248e8b0a1417ce2651f722023-07-18T10:52:05ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2023-07-0112110.4274/mjima.galenos.2022.2023.11Prevalence of Asymptomatic HIV-associated Neurocognitive Disorder in a Tertiary Care Hospital in South India: A Single Centered Observational StudyNivedhithaa SELVARAJ0https://orcid.org/0000-0002-5854-1665Yoganathan CHIDAMBARAM1https://orcid.org/0000-0002-3153-8183C. P. Clement Jenil DHAS2https://orcid.org/0000-0002-5237-8326Abilash NEKKANTI3https://orcid.org/0000-0002-4136-8659Petchiappan VELAMMAL4https://orcid.org/0000-0002-0339-2578Bhargavi KUMAR5https://orcid.org/0000-0002-9799-0332Murali ALAGESAN6https://orcid.org/0000-0002-5876-4033Hessenklinik Stadtkrankenhaus Hospital, Hessen, GermanyPSG Institute of Medical Sciences and Research, Tamil Nadu, IndiaPSG Institute of Medical Sciences and Research, Tamil Nadu, IndiaPSG Institute of Medical Sciences and Research, Tamil Nadu, IndiaPSG Institute of Medical Sciences and Research, Tamil Nadu, IndiaPSG Institute of Medical Sciences and Research, Tamil Nadu, IndiaPSG Institute of Medical Sciences and Research, Tamil Nadu, IndiaIntroduction: Asymptomatic HIV-associated neurocognitive disorder (HAND) is associated with increased morbidity, and it often goes undetected in outpatient clinics due to the lack of awareness and time constraints for a detailed assessment in such cases. We assessed the prevalence of HAND by using Montreal Cognitive Assessment (MoCA) test and evaluated the association between the severity of HIV using CD4 count and cognitive impairment. Materials and Methods: This cross-sectional study enrolled 103 patients (age: 20-80 years) living with HIV who were sampled through convenient sampling technique. Demographic details such as the age, sex, and education, and the current CD4 count were recorded and the patients were accordingly assigned to the following groups: A (>500 cells/µl), B (200-499 cells/µl), and C (<200 cells/µl) with reference to the Center for Disease Control and Prevention guidelines for the distribution of CD4+T cells in HIV. Cognitive impairment in patients was screened using MoCA with a cut-off score of <26. Data was defined using descriptive statistics, between-group comparison was performed using ANOVA and chi-square tests, and the association between the MoCA score and CD4 count was assessed by using Spearman’s correlation coefficient. P<05 was considered to indicate statistical significance. Results: HIV-associated neurocognitive disorder was prevalent among 73.8% of the sample population, where 8.7% had severe, 18.4% had moderate, and 46.6% had mild impairment. Based on the CD4 count, 10.6% were categorized into group A, 39.8% into group B, and 49.5% into group C. The association of the MoCA score with CD4 count was found to be moderately positive and statistically significant (r2=0.644, p=0.000). Conclusion: A high prevalence of HAND, specifically an asymptomatic form, was observed among patients living with HIV. The MoCA score was significantly associated with CD4 count, albeit moderately positive.https://mjima.org/text.php?&id=377hivneurocognitive disordersmontreal cognitive assessmentprevalenceasymptomatic |
| spellingShingle | Nivedhithaa SELVARAJ Yoganathan CHIDAMBARAM C. P. Clement Jenil DHAS Abilash NEKKANTI Petchiappan VELAMMAL Bhargavi KUMAR Murali ALAGESAN Prevalence of Asymptomatic HIV-associated Neurocognitive Disorder in a Tertiary Care Hospital in South India: A Single Centered Observational Study Mediterranean Journal of Infection, Microbes and Antimicrobials hiv neurocognitive disorders montreal cognitive assessment prevalence asymptomatic |
| title | Prevalence of Asymptomatic HIV-associated Neurocognitive Disorder in a Tertiary Care Hospital in South India: A Single Centered Observational Study |
| title_full | Prevalence of Asymptomatic HIV-associated Neurocognitive Disorder in a Tertiary Care Hospital in South India: A Single Centered Observational Study |
| title_fullStr | Prevalence of Asymptomatic HIV-associated Neurocognitive Disorder in a Tertiary Care Hospital in South India: A Single Centered Observational Study |
| title_full_unstemmed | Prevalence of Asymptomatic HIV-associated Neurocognitive Disorder in a Tertiary Care Hospital in South India: A Single Centered Observational Study |
| title_short | Prevalence of Asymptomatic HIV-associated Neurocognitive Disorder in a Tertiary Care Hospital in South India: A Single Centered Observational Study |
| title_sort | prevalence of asymptomatic hiv associated neurocognitive disorder in a tertiary care hospital in south india a single centered observational study |
| topic | hiv neurocognitive disorders montreal cognitive assessment prevalence asymptomatic |
| url | https://mjima.org/text.php?&id=377 |
| work_keys_str_mv | AT nivedhithaaselvaraj prevalenceofasymptomatichivassociatedneurocognitivedisorderinatertiarycarehospitalinsouthindiaasinglecenteredobservationalstudy AT yoganathanchidambaram prevalenceofasymptomatichivassociatedneurocognitivedisorderinatertiarycarehospitalinsouthindiaasinglecenteredobservationalstudy AT cpclementjenildhas prevalenceofasymptomatichivassociatedneurocognitivedisorderinatertiarycarehospitalinsouthindiaasinglecenteredobservationalstudy AT abilashnekkanti prevalenceofasymptomatichivassociatedneurocognitivedisorderinatertiarycarehospitalinsouthindiaasinglecenteredobservationalstudy AT petchiappanvelammal prevalenceofasymptomatichivassociatedneurocognitivedisorderinatertiarycarehospitalinsouthindiaasinglecenteredobservationalstudy AT bhargavikumar prevalenceofasymptomatichivassociatedneurocognitivedisorderinatertiarycarehospitalinsouthindiaasinglecenteredobservationalstudy AT muralialagesan prevalenceofasymptomatichivassociatedneurocognitivedisorderinatertiarycarehospitalinsouthindiaasinglecenteredobservationalstudy |