Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts
Healthcare systems across the world face major challenges due to allergic diseases, known to affect people of all ages. In Singapore, two prominent cohort studies, Growing Up in Singapore Towards healthy Outcomes (GUSTO) and the Singapore PREconception Study of long-Term maternal and child Outcomes...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893023000874 |
| _version_ | 1797365566588059648 |
|---|---|
| author | Noor H.A. Suaini Hugo Van Bever Elizabeth Huiwen Tham |
| author_facet | Noor H.A. Suaini Hugo Van Bever Elizabeth Huiwen Tham |
| author_sort | Noor H.A. Suaini |
| collection | DOAJ |
| description | Healthcare systems across the world face major challenges due to allergic diseases, known to affect people of all ages. In Singapore, two prominent cohort studies, Growing Up in Singapore Towards healthy Outcomes (GUSTO) and the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO), have made notable advancements to our knowledge and understanding of allergic diseases. These cohorts, which comprised of healthy mother-infant dyads recruited from the healthy Singapore population, have shed light on the complex connections between factors influencing health in early life, preconception and pregnancy, on the pathogenesis of allergic disorders in offspring.GUSTO highlighted significant risk factors in antenatal and early life, such as maternal diet, health and lifestyle choices, as well as infant environmental influences, that contributed to the risk of allergic diseases in the Asian Singaporean population. It also identified differential patterns of allergic disease in comparison to other populations, particularly the role of the microbiome in predicting atopic outcomes. Meanwhile, S-PRESTO further explores the long-term maternal and child outcomes associated with preconception health. Findings seem to suggest that prevention of offspring allergic conditions can be achieved through optimizing maternal health and lifestyle choices before conception.Both studies underscore the significance of early life interventions, preconception health, and personalized approaches to effectively manage and prevent allergies. By leveraging the insights and promising findings from GUSTO and S-PRESTO, future work can drive development of preventative strategies and personalized interventions to reduce burden of allergic diseases in the Singapore population. |
| first_indexed | 2024-03-08T16:51:46Z |
| format | Article |
| id | doaj.art-2b5c85eb65d04fc3bd24523cae0d8279 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-03-08T16:51:46Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-2b5c85eb65d04fc3bd24523cae0d82792024-01-05T04:23:48ZengElsevierAllergology International1323-89302024-01-017311319Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohortsNoor H.A. Suaini0Hugo Van Bever1Elizabeth Huiwen Tham2Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System (NUHS), SingaporeSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System (NUHS), Singapore; Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore; Corresponding author. Division of Allergy & Immunology, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Level 12 NUHS Tower Block, 119228, Singapore.Healthcare systems across the world face major challenges due to allergic diseases, known to affect people of all ages. In Singapore, two prominent cohort studies, Growing Up in Singapore Towards healthy Outcomes (GUSTO) and the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO), have made notable advancements to our knowledge and understanding of allergic diseases. These cohorts, which comprised of healthy mother-infant dyads recruited from the healthy Singapore population, have shed light on the complex connections between factors influencing health in early life, preconception and pregnancy, on the pathogenesis of allergic disorders in offspring.GUSTO highlighted significant risk factors in antenatal and early life, such as maternal diet, health and lifestyle choices, as well as infant environmental influences, that contributed to the risk of allergic diseases in the Asian Singaporean population. It also identified differential patterns of allergic disease in comparison to other populations, particularly the role of the microbiome in predicting atopic outcomes. Meanwhile, S-PRESTO further explores the long-term maternal and child outcomes associated with preconception health. Findings seem to suggest that prevention of offspring allergic conditions can be achieved through optimizing maternal health and lifestyle choices before conception.Both studies underscore the significance of early life interventions, preconception health, and personalized approaches to effectively manage and prevent allergies. By leveraging the insights and promising findings from GUSTO and S-PRESTO, future work can drive development of preventative strategies and personalized interventions to reduce burden of allergic diseases in the Singapore population.http://www.sciencedirect.com/science/article/pii/S1323893023000874AsiaAtopic dermatitisFood hypersensitivityRespiratory morbiditySensitization |
| spellingShingle | Noor H.A. Suaini Hugo Van Bever Elizabeth Huiwen Tham Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts Allergology International Asia Atopic dermatitis Food hypersensitivity Respiratory morbidity Sensitization |
| title | Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts |
| title_full | Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts |
| title_fullStr | Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts |
| title_full_unstemmed | Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts |
| title_short | Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts |
| title_sort | growing up in singapore with allergies lessons learnt from the gusto amp s presto cohorts |
| topic | Asia Atopic dermatitis Food hypersensitivity Respiratory morbidity Sensitization |
| url | http://www.sciencedirect.com/science/article/pii/S1323893023000874 |
| work_keys_str_mv | AT noorhasuaini growingupinsingaporewithallergieslessonslearntfromthegustoampsprestocohorts AT hugovanbever growingupinsingaporewithallergieslessonslearntfromthegustoampsprestocohorts AT elizabethhuiwentham growingupinsingaporewithallergieslessonslearntfromthegustoampsprestocohorts |