Synthesis of 2,5-Disubstituted Octahydroquinolin-4-ones via anIntramolecular Hetero Diels-Alder Reaction

Synthesis of 2,5-Disubstituted Octahydroquinolin-4-ones via anIntramolecular Hetero Diels-Alder Reaction

A route for the preparation of 2,5-disubstituted octahydroquinolin-4-ones, synthetic precursors of the decahydroquinoline-type toxins, is presented. The key steps are an asymmetric epoxidation and an intramolecular hetero Diels-Alder reaction between an activated diene and an imine. The presence of...

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Bibliographic Details
Main Authors: J. Antonio Palenzuela, Maria M. Afonso, Juan M. Ruiz
Format: Article
Language:English
Published: MDPI AG 2007-02-01
Series:Molecules
Subjects:
Hetero Diels-Alder
alkaloids
octahydroquinolone
Online Access:http://www.mdpi.com/1420-3049/12/2/194/

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