Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish I...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-05-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019337146 |
| _version_ | 1819170709774008320 |
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| author | Serena Fossati Damaskini Valvi David Martinez Marta Cirach Marisa Estarlich Ana Fernández-Somoano Mònica Guxens Carmen Iñiguez Amaia Irizar Aitana Lertxundi Mark Nieuwenhuijsen Ibon Tamayo Jesus Vioque Adonina Tardón Jordi Sunyer Martine Vrijheid |
| author_facet | Serena Fossati Damaskini Valvi David Martinez Marta Cirach Marisa Estarlich Ana Fernández-Somoano Mònica Guxens Carmen Iñiguez Amaia Irizar Aitana Lertxundi Mark Nieuwenhuijsen Ibon Tamayo Jesus Vioque Adonina Tardón Jordi Sunyer Martine Vrijheid |
| author_sort | Serena Fossati |
| collection | DOAJ |
| description | Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003–2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnancy was associated with decreased z-scores of weight (zWeight) and BMI (zBMI) (zWeight change per interquartile range increase in PM2.5 exposure = −0.12; 95% CI: −0.23, −0.01; zBMI change = −0.12; 95% CI: −0.23, −0.01). Higher NO2 and PM2.5 exposure was associated to a reduced risk of being in a trajectory with accelerated BMI gain, compared to children with the average trajectory. Birth weight partially mediated the association between PM2.5 and zWeight and zBMI. PM2.5 and NO2 were not associated with the other cardio-metabolic risk factors. Conclusions: This comprehensive study of many growth and cardio-metabolic risk related outcomes suggests that air pollution exposure during pregnancy may be associated with delays in physical growth in the early years after birth. These findings imply that pregnancy exposure to air pollutants has a lasting effect on growth after birth and require follow-up at later child ages. Keywords: Air pollution, Prenatal exposure, Childhood growth, Childhood obesity, Particulate matter |
| first_indexed | 2024-12-22T19:39:43Z |
| format | Article |
| id | doaj.art-2b5e68aa053c4ed098ed55967494732a |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-22T19:39:43Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-2b5e68aa053c4ed098ed55967494732a2022-12-21T18:14:53ZengElsevierEnvironment International0160-41202020-05-01138Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolersSerena Fossati0Damaskini Valvi1David Martinez2Marta Cirach3Marisa Estarlich4Ana Fernández-Somoano5Mònica Guxens6Carmen Iñiguez7Amaia Irizar8Aitana Lertxundi9Mark Nieuwenhuijsen10Ibon Tamayo11Jesus Vioque12Adonina Tardón13Jordi Sunyer14Martine Vrijheid15ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Corresponding author at: ISGlobal – Barcelona Institute for Global Health – Campus MAR, Barcelona Biomedical Research Park (PRBB) (office 182.01), Doctor Aiguader, 88, 08003 Barcelona, Spain.Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainCIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Nursing, Faculty of Nursing and Chiropody, University of Valencia; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, 46020, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Spain; IUOPA-Departamento de Medicina, University of Oviedo, Oviedo, Spain; Institute of Health Research of the Principality of Asturias - Foundation for Biosanitary Research of Asturias (ISPA-FINBA), Oviedo, SpainISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children’s Hospital, Rotterdam, the NetherlandsCIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Statistics and Computational Research, Universitat de València, Valencia, SpainBiodonostia Health Research Institute, Donostia, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Spain; Biodonostia Health Research Institute, Donostia, Spain; Faculty of Medicine and Nursing of the University of the Basque Country, Bilbao, SpainISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Division of Immunology and Immunotherapy, Cima, Universidad de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdISNA), Pamplona, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Spain; Universidad Miguel Hernandez, ISABIAL-FISABIO, Alicante, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Spain; IUOPA-Departamento de Medicina, University of Oviedo, Oviedo, Spain; Institute of Health Research of the Principality of Asturias - Foundation for Biosanitary Research of Asturias (ISPA-FINBA), Oviedo, SpainISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainObjectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003–2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnancy was associated with decreased z-scores of weight (zWeight) and BMI (zBMI) (zWeight change per interquartile range increase in PM2.5 exposure = −0.12; 95% CI: −0.23, −0.01; zBMI change = −0.12; 95% CI: −0.23, −0.01). Higher NO2 and PM2.5 exposure was associated to a reduced risk of being in a trajectory with accelerated BMI gain, compared to children with the average trajectory. Birth weight partially mediated the association between PM2.5 and zWeight and zBMI. PM2.5 and NO2 were not associated with the other cardio-metabolic risk factors. Conclusions: This comprehensive study of many growth and cardio-metabolic risk related outcomes suggests that air pollution exposure during pregnancy may be associated with delays in physical growth in the early years after birth. These findings imply that pregnancy exposure to air pollutants has a lasting effect on growth after birth and require follow-up at later child ages. Keywords: Air pollution, Prenatal exposure, Childhood growth, Childhood obesity, Particulate matterhttp://www.sciencedirect.com/science/article/pii/S0160412019337146 |
| spellingShingle | Serena Fossati Damaskini Valvi David Martinez Marta Cirach Marisa Estarlich Ana Fernández-Somoano Mònica Guxens Carmen Iñiguez Amaia Irizar Aitana Lertxundi Mark Nieuwenhuijsen Ibon Tamayo Jesus Vioque Adonina Tardón Jordi Sunyer Martine Vrijheid Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers Environment International |
| title | Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers |
| title_full | Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers |
| title_fullStr | Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers |
| title_full_unstemmed | Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers |
| title_short | Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers |
| title_sort | prenatal air pollution exposure and growth and cardio metabolic risk in preschoolers |
| url | http://www.sciencedirect.com/science/article/pii/S0160412019337146 |
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