Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension​

Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension​

Abstract Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B4 (LXB4), produced by retinal astrocytes, has direct neuroprotective actions on retinal ganglion cells. In this study, we aimed to in...

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Bibliographic Details
Main Authors: Shruthi Karnam, Shubham Maurya, Elainna Ng, Amodini Choudhary, Arzin Thobani, John G Flanagan, Karsten Gronert
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Acta Neuropathologica Communications
Subjects:
Glaucoma
Astrocyte reactivity
Lipoxygenase
Lipoxin B4
Neurodegeneration
Retina
Online Access:https://doi.org/10.1186/s40478-024-01767-2

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