Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits
Fruit peels of Plinia cauliflora (Mart.) Kausel are widely used in Brazilian traditional medicine, but no studies have proved the safety of its pharmacological effects on the respiratory, cardiovascular, and central nervous systems. The present study assessed the safety pharmacology of P. cauliflora...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Toxicology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750018306449 |
| _version_ | 1811269854250926080 |
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| author | Rhanany Alan Calloi Palozi Lucas Pires Guarnier Paulo Vitor Moreira Romão Samara Requena Nocchi Carlos Calixto dos Santos Emerson Luiz Botelho Lourenço Denise Brentan Silva Francielly Mourão Gasparotto Arquimedes Gasparotto Junior |
| author_facet | Rhanany Alan Calloi Palozi Lucas Pires Guarnier Paulo Vitor Moreira Romão Samara Requena Nocchi Carlos Calixto dos Santos Emerson Luiz Botelho Lourenço Denise Brentan Silva Francielly Mourão Gasparotto Arquimedes Gasparotto Junior |
| author_sort | Rhanany Alan Calloi Palozi |
| collection | DOAJ |
| description | Fruit peels of Plinia cauliflora (Mart.) Kausel are widely used in Brazilian traditional medicine, but no studies have proved the safety of its pharmacological effects on the respiratory, cardiovascular, and central nervous systems. The present study assessed the safety pharmacology of P. cauliflora in New Zealand rabbits. First, an ethanol extract (EEPC) was selected for the pharmacological experiments and chemical characterization. Then, different groups of rabbits were orally treated with EEPC (200 and 2000 mg/kg) or vehicle. Acute behavioral and physiological alterations in the modified Irwin test, respiratory rate, arterial blood gas, and various cardiovascular parameters (i.e., heart rate, blood pressure, and electrocardiography) were evaluated. The main secondary metabolites that were identified in EEPC were ellagic acid, gallic acid, O-deoxyhexosyl quercetin, and the anthocyanin O-hexosyl cyanidin. No significant behavioral or physiological changes were observed in any of the groups. None of the doses of EEPC affected respiratory rate or arterial blood gas, with no changes on blood pressure or electrocardiographic parameters. The present study showed that EEPC did not cause any significant changes in respiratory, cardiovascular, or central nervous system function. These data provide scientific evidence of the effects of this species and important safety data for its clinical use. Keywords: Cardiovascular, Irwin test, Myrtaceae, Respiratory, Toxicology |
| first_indexed | 2024-04-12T21:49:31Z |
| format | Article |
| id | doaj.art-2b619b2fdffd4b11a982671cc2f81a34 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-12T21:49:31Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-2b619b2fdffd4b11a982671cc2f81a342022-12-22T03:15:31ZengElsevierToxicology Reports2214-75002019-01-016616624Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbitsRhanany Alan Calloi Palozi0Lucas Pires Guarnier1Paulo Vitor Moreira Romão2Samara Requena Nocchi3Carlos Calixto dos Santos4Emerson Luiz Botelho Lourenço5Denise Brentan Silva6Francielly Mourão Gasparotto7Arquimedes Gasparotto Junior8Laboratório de Eletrofisiologia e Farmacologia Cardiovascular (LEFaC), Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, BrazilLaboratório de Eletrofisiologia e Farmacologia Cardiovascular (LEFaC), Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, BrazilLaboratório de Eletrofisiologia e Farmacologia Cardiovascular (LEFaC), Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, BrazilLaboratório de Produtos Naturais e Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, BrazilLaboratório de Pesquisa Pré-Clínica de Produtos Naturais, Universidade Paranaense, Umuarama, PR, BrazilLaboratório de Pesquisa Pré-Clínica de Produtos Naturais, Universidade Paranaense, Umuarama, PR, BrazilLaboratório de Produtos Naturais e Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, BrazilLaboratório de Eletrofisiologia e Farmacologia Cardiovascular (LEFaC), Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, BrazilLaboratório de Eletrofisiologia e Farmacologia Cardiovascular (LEFaC), Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil; Corresponding author.Fruit peels of Plinia cauliflora (Mart.) Kausel are widely used in Brazilian traditional medicine, but no studies have proved the safety of its pharmacological effects on the respiratory, cardiovascular, and central nervous systems. The present study assessed the safety pharmacology of P. cauliflora in New Zealand rabbits. First, an ethanol extract (EEPC) was selected for the pharmacological experiments and chemical characterization. Then, different groups of rabbits were orally treated with EEPC (200 and 2000 mg/kg) or vehicle. Acute behavioral and physiological alterations in the modified Irwin test, respiratory rate, arterial blood gas, and various cardiovascular parameters (i.e., heart rate, blood pressure, and electrocardiography) were evaluated. The main secondary metabolites that were identified in EEPC were ellagic acid, gallic acid, O-deoxyhexosyl quercetin, and the anthocyanin O-hexosyl cyanidin. No significant behavioral or physiological changes were observed in any of the groups. None of the doses of EEPC affected respiratory rate or arterial blood gas, with no changes on blood pressure or electrocardiographic parameters. The present study showed that EEPC did not cause any significant changes in respiratory, cardiovascular, or central nervous system function. These data provide scientific evidence of the effects of this species and important safety data for its clinical use. Keywords: Cardiovascular, Irwin test, Myrtaceae, Respiratory, Toxicologyhttp://www.sciencedirect.com/science/article/pii/S2214750018306449 |
| spellingShingle | Rhanany Alan Calloi Palozi Lucas Pires Guarnier Paulo Vitor Moreira Romão Samara Requena Nocchi Carlos Calixto dos Santos Emerson Luiz Botelho Lourenço Denise Brentan Silva Francielly Mourão Gasparotto Arquimedes Gasparotto Junior Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits Toxicology Reports |
| title | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
| title_full | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
| title_fullStr | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
| title_full_unstemmed | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
| title_short | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
| title_sort | pharmacological safety of plinia cauliflora mart kausel in rabbits |
| url | http://www.sciencedirect.com/science/article/pii/S2214750018306449 |
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