Potential prognostic roles of serum lactate and Creatine kinase levels in poisoned patients
Abstract Background Examination of serum lactate level and its changes, as an indicator of tissue oxygenation, as well as level of creatine kinase (CK) inhibitors, as a factor of mortality which partially expresses heart, brain, and muscle damage, may be considered as tools to determine prognosis in...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | BMC Emergency Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12873-020-00326-x |
| _version_ | 1828388617907601408 |
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| author | Alireza Golaghaei Hossein Hassanian-Moghaddam Shahin Shadnia Nasim Zamani Fatemeh Amraei |
| author_facet | Alireza Golaghaei Hossein Hassanian-Moghaddam Shahin Shadnia Nasim Zamani Fatemeh Amraei |
| author_sort | Alireza Golaghaei |
| collection | DOAJ |
| description | Abstract Background Examination of serum lactate level and its changes, as an indicator of tissue oxygenation, as well as level of creatine kinase (CK) inhibitors, as a factor of mortality which partially expresses heart, brain, and muscle damage, may be considered as tools to determine prognosis in critically ill patients. We aimed to evaluate these two factors as potential prognostic factors in critically poisoned patients admitted to our toxicology ICU. Method This is a cross-sectional descriptive-analytic study that was performed on poisoned patients referred to emergency department of Loghman Hakim Hospital. One-hundred critically poisoned patients who had been admitted to ICU were conveniently chosen using a random number table and included into the study after obtaining consent forms from their next of kin. Their serum lactate and CK levels were checked on admission. These levels were compared subsequently between survivors and non-survivors to seek for their potential prognostic role. Results In a total of 100 patients enrolled, 61 were male. Serum level of lactate (with a cut off of 26 mg/dL) and serum CK with a cutoff point of 169 U/L could have prognosticated death with sensitivity and specificity of 78 and 77% (for lactate) and 74 and 62% (for serum CK), respectively. Conclusions In poisoned patients, serum lactate and CK can be used as possible prognostic factors because they rapidly increase in the serum and are easily detectable. |
| first_indexed | 2024-12-10T06:14:35Z |
| format | Article |
| id | doaj.art-2b623aa19d9a47209502e15e71bff303 |
| institution | Directory Open Access Journal |
| issn | 1471-227X |
| language | English |
| last_indexed | 2024-12-10T06:14:35Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Emergency Medicine |
| spelling | doaj.art-2b623aa19d9a47209502e15e71bff3032022-12-22T01:59:28ZengBMCBMC Emergency Medicine1471-227X2020-04-012011510.1186/s12873-020-00326-xPotential prognostic roles of serum lactate and Creatine kinase levels in poisoned patientsAlireza Golaghaei0Hossein Hassanian-Moghaddam1Shahin Shadnia2Nasim Zamani3Fatemeh Amraei4AJA University of Medical SciencesDepartment of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesDepartment of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesDepartment of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesTehran University of Medical ScienceAbstract Background Examination of serum lactate level and its changes, as an indicator of tissue oxygenation, as well as level of creatine kinase (CK) inhibitors, as a factor of mortality which partially expresses heart, brain, and muscle damage, may be considered as tools to determine prognosis in critically ill patients. We aimed to evaluate these two factors as potential prognostic factors in critically poisoned patients admitted to our toxicology ICU. Method This is a cross-sectional descriptive-analytic study that was performed on poisoned patients referred to emergency department of Loghman Hakim Hospital. One-hundred critically poisoned patients who had been admitted to ICU were conveniently chosen using a random number table and included into the study after obtaining consent forms from their next of kin. Their serum lactate and CK levels were checked on admission. These levels were compared subsequently between survivors and non-survivors to seek for their potential prognostic role. Results In a total of 100 patients enrolled, 61 were male. Serum level of lactate (with a cut off of 26 mg/dL) and serum CK with a cutoff point of 169 U/L could have prognosticated death with sensitivity and specificity of 78 and 77% (for lactate) and 74 and 62% (for serum CK), respectively. Conclusions In poisoned patients, serum lactate and CK can be used as possible prognostic factors because they rapidly increase in the serum and are easily detectable.http://link.springer.com/article/10.1186/s12873-020-00326-xLactateCreatine kinasePoisoningPrognostic factor |
| spellingShingle | Alireza Golaghaei Hossein Hassanian-Moghaddam Shahin Shadnia Nasim Zamani Fatemeh Amraei Potential prognostic roles of serum lactate and Creatine kinase levels in poisoned patients BMC Emergency Medicine Lactate Creatine kinase Poisoning Prognostic factor |
| title | Potential prognostic roles of serum lactate and Creatine kinase levels in poisoned patients |
| title_full | Potential prognostic roles of serum lactate and Creatine kinase levels in poisoned patients |
| title_fullStr | Potential prognostic roles of serum lactate and Creatine kinase levels in poisoned patients |
| title_full_unstemmed | Potential prognostic roles of serum lactate and Creatine kinase levels in poisoned patients |
| title_short | Potential prognostic roles of serum lactate and Creatine kinase levels in poisoned patients |
| title_sort | potential prognostic roles of serum lactate and creatine kinase levels in poisoned patients |
| topic | Lactate Creatine kinase Poisoning Prognostic factor |
| url | http://link.springer.com/article/10.1186/s12873-020-00326-x |
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