The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis
Abstract Background Gastrointestinal stromal tumors (GISTs) of the stomach are the most common GISTs. The risk, incidence, and outcome of cancer are different between the sexes. Whether gender is related to the prognosis of gastric stromal tumors is unclear. Therefore, this study aims to explore the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13293-020-00321-8 |
| _version_ | 1818342446806859776 |
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| author | Jianfang Rong Sihai Chen Conghua Song Huan Wang Qiaoyun Zhao Rulin Zhao Yajing He Lili Yan Yanping Song Fangfei Wang Yong Xie |
| author_facet | Jianfang Rong Sihai Chen Conghua Song Huan Wang Qiaoyun Zhao Rulin Zhao Yajing He Lili Yan Yanping Song Fangfei Wang Yong Xie |
| author_sort | Jianfang Rong |
| collection | DOAJ |
| description | Abstract Background Gastrointestinal stromal tumors (GISTs) of the stomach are the most common GISTs. The risk, incidence, and outcome of cancer are different between the sexes. Whether gender is related to the prognosis of gastric stromal tumors is unclear. Therefore, this study aims to explore the relationship between gender and gastric GIST prognosis. Methods Data from gastric GIST patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was performed to reduce confounding factors, and the clinicopathological features and prognosis of GIST patients were comprehensively evaluated. Results There were 512 male patients and 538 female patients with gastric GIST. The gender of gastric GIST patients was associated with marital status, surgical treatment, tumor size, and mitotic index (P < 0.05). The Kaplan-Meier analysis and log-rank test revealed that male patients had a higher mortality rate than female patients (P = 0.0024). After matching all the potential confounding factors, the survival of the female gastric GIST patients was better than that of the male gastric GIST patients (P = 0.042). Cox regression analysis revealed that gender was an independent risk factor for overall survival. The risk of death was higher for males than for females (HR 1.677, 95% CI 1.150–2.444, P = 0.007). Conclusion Gender could be a prognostic factor for gastric GIST survival, and male patients had a higher risk of death. |
| first_indexed | 2024-12-13T16:14:49Z |
| format | Article |
| id | doaj.art-2b6344e0b60647ad916539a1fb499cfe |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-12-13T16:14:49Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-2b6344e0b60647ad916539a1fb499cfe2022-12-21T23:38:51ZengBMCBiology of Sex Differences2042-64102020-07-011111710.1186/s13293-020-00321-8The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysisJianfang Rong0Sihai Chen1Conghua Song2Huan Wang3Qiaoyun Zhao4Rulin Zhao5Yajing He6Lili Yan7Yanping Song8Fangfei Wang9Yong Xie10Department of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityAbstract Background Gastrointestinal stromal tumors (GISTs) of the stomach are the most common GISTs. The risk, incidence, and outcome of cancer are different between the sexes. Whether gender is related to the prognosis of gastric stromal tumors is unclear. Therefore, this study aims to explore the relationship between gender and gastric GIST prognosis. Methods Data from gastric GIST patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was performed to reduce confounding factors, and the clinicopathological features and prognosis of GIST patients were comprehensively evaluated. Results There were 512 male patients and 538 female patients with gastric GIST. The gender of gastric GIST patients was associated with marital status, surgical treatment, tumor size, and mitotic index (P < 0.05). The Kaplan-Meier analysis and log-rank test revealed that male patients had a higher mortality rate than female patients (P = 0.0024). After matching all the potential confounding factors, the survival of the female gastric GIST patients was better than that of the male gastric GIST patients (P = 0.042). Cox regression analysis revealed that gender was an independent risk factor for overall survival. The risk of death was higher for males than for females (HR 1.677, 95% CI 1.150–2.444, P = 0.007). Conclusion Gender could be a prognostic factor for gastric GIST survival, and male patients had a higher risk of death.http://link.springer.com/article/10.1186/s13293-020-00321-8GenderGastric gastrointestinal stromal tumorPropensity score matching |
| spellingShingle | Jianfang Rong Sihai Chen Conghua Song Huan Wang Qiaoyun Zhao Rulin Zhao Yajing He Lili Yan Yanping Song Fangfei Wang Yong Xie The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis Biology of Sex Differences Gender Gastric gastrointestinal stromal tumor Propensity score matching |
| title | The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis |
| title_full | The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis |
| title_fullStr | The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis |
| title_full_unstemmed | The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis |
| title_short | The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis |
| title_sort | prognostic value of gender in gastric gastrointestinal stromal tumors a propensity score matching analysis |
| topic | Gender Gastric gastrointestinal stromal tumor Propensity score matching |
| url | http://link.springer.com/article/10.1186/s13293-020-00321-8 |
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