Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro

Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro

Free fatty acids (FFA), hyperglycemia, and inflammatory cytokines are major mediators of β-cell toxicity in type 2 diabetes mellitus, impairing mitochondrial metabolism. Glutaredoxin 5 (Glrx5) is a mitochondrial protein involved in the assembly of iron–sulfur clusters required for complexes of the r...

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Bibliographic Details
Main Authors: Sebastian Friedrich Petry, Axel Römer, Divya Rawat, Lara Brunner, Nina Lerch, Mengmeng Zhou, Rekha Grewal, Fatemeh Sharifpanah, Heinrich Sauer, Gunter Peter Eckert, Thomas Linn
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Antioxidants
Subjects:
glutaredoxin
β-cell
high fat diet
diabetes
obesity
mitochondria
Online Access:https://www.mdpi.com/2076-3921/11/4/788

Internet

https://www.mdpi.com/2076-3921/11/4/788

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