COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles?
Every day, new information is presented with respect to how to best combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This manuscript sheds light on such recent findings, including new co-factors (i.e., neuropilin-1) and routes (i.e., olfactory transmucosal) allowing cell entr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/3/796 |
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| author | Dina A. Mosselhy Jenni Virtanen Ravi Kant Wei He Mady Elbahri Tarja Sironen |
| author_facet | Dina A. Mosselhy Jenni Virtanen Ravi Kant Wei He Mady Elbahri Tarja Sironen |
| author_sort | Dina A. Mosselhy |
| collection | DOAJ |
| description | Every day, new information is presented with respect to how to best combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This manuscript sheds light on such recent findings, including new co-factors (i.e., neuropilin-1) and routes (i.e., olfactory transmucosal) allowing cell entry of SARS-CoV-2 and induction of neurological symptoms, as well as the new SARS-CoV-2 variants. We highlight the SARS-CoV-2 human–animal interfaces and elaborate containment strategies using the same vaccination (i.e., nanoparticle “NP” formulations of the BNT162b2 and mRNA-1273 vaccines) for humans, minks, raccoon dogs, cats, and zoo animals. We investigate the toxicity issues of anti-CoV NPs (i.e., plasmonic NPs and quantum dots) on different levels. Namely, nano–bio interfaces (i.e., protein corona), in vitro (i.e., lung cells) and in vivo (i.e., zebrafish embryos) assessments, and impacts on humans are discussed in a narrative supported by original figures. Ultimately, we express our skeptical opinion on the comprehensive administration of such antiviral nanotheranostics, even when integrated into facemasks, because of their reported toxicities and the different NP parameters (e.g., size, shape, surface charge, and purity and chemical composition of NPs) that govern their end toxicity. We believe that more toxicity studies should be performed and be presented, clarifying the odds of the safe administration of nanotoxocological solutions and the relief of a worried public. |
| first_indexed | 2024-03-10T13:03:38Z |
| format | Article |
| id | doaj.art-2b660a42b033473ba126e1a6a78b1c61 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T13:03:38Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-2b660a42b033473ba126e1a6a78b1c612023-11-21T11:16:04ZengMDPI AGNanomaterials2079-49912021-03-0111379610.3390/nano11030796COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles?Dina A. Mosselhy0Jenni Virtanen1Ravi Kant2Wei He3Mady Elbahri4Tarja Sironen5Department of Virology, Faculty of Medicine, University of Helsinki, P.O. Box 21, 00014 Helsinki, FinlandDepartment of Virology, Faculty of Medicine, University of Helsinki, P.O. Box 21, 00014 Helsinki, FinlandDepartment of Virology, Faculty of Medicine, University of Helsinki, P.O. Box 21, 00014 Helsinki, FinlandSchool of Materials Science and Engineering, University of Science and Technology, Beijing 100083, ChinaNanochemistry and Nanoengineering, Department of Chemistry and Materials Science, School of Chemical Engineering, Aalto University, 02150 Espoo, FinlandDepartment of Virology, Faculty of Medicine, University of Helsinki, P.O. Box 21, 00014 Helsinki, FinlandEvery day, new information is presented with respect to how to best combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This manuscript sheds light on such recent findings, including new co-factors (i.e., neuropilin-1) and routes (i.e., olfactory transmucosal) allowing cell entry of SARS-CoV-2 and induction of neurological symptoms, as well as the new SARS-CoV-2 variants. We highlight the SARS-CoV-2 human–animal interfaces and elaborate containment strategies using the same vaccination (i.e., nanoparticle “NP” formulations of the BNT162b2 and mRNA-1273 vaccines) for humans, minks, raccoon dogs, cats, and zoo animals. We investigate the toxicity issues of anti-CoV NPs (i.e., plasmonic NPs and quantum dots) on different levels. Namely, nano–bio interfaces (i.e., protein corona), in vitro (i.e., lung cells) and in vivo (i.e., zebrafish embryos) assessments, and impacts on humans are discussed in a narrative supported by original figures. Ultimately, we express our skeptical opinion on the comprehensive administration of such antiviral nanotheranostics, even when integrated into facemasks, because of their reported toxicities and the different NP parameters (e.g., size, shape, surface charge, and purity and chemical composition of NPs) that govern their end toxicity. We believe that more toxicity studies should be performed and be presented, clarifying the odds of the safe administration of nanotoxocological solutions and the relief of a worried public.https://www.mdpi.com/2079-4991/11/3/796SARS-CoV-2human–animal interfacesnanoparticlesnanotoxicologylung cell lineszebrafish |
| spellingShingle | Dina A. Mosselhy Jenni Virtanen Ravi Kant Wei He Mady Elbahri Tarja Sironen COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles? Nanomaterials SARS-CoV-2 human–animal interfaces nanoparticles nanotoxicology lung cell lines zebrafish |
| title | COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles? |
| title_full | COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles? |
| title_fullStr | COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles? |
| title_full_unstemmed | COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles? |
| title_short | COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles? |
| title_sort | covid 19 pandemic what about the safety of anti coronavirus nanoparticles |
| topic | SARS-CoV-2 human–animal interfaces nanoparticles nanotoxicology lung cell lines zebrafish |
| url | https://www.mdpi.com/2079-4991/11/3/796 |
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