Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature Review
Harlequin ichthyosis (HI) is an extremely rare and severe genetic skin disorder characterized by thick, diamond-shaped scales covering the body, often giving the appearance of a harlequin costume. This paper provides an overview of the genetic and dermatological aspects of HI, delving into its etiol...
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2024-03-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://www.ijbm.org/articles/i53/ijbm_14(1)_cr7.pdf |
| _version_ | 1797281448929001472 |
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| author | Brikene Elshani Astrit M. Gashi Besa Selimi Arion Elshani |
| author_facet | Brikene Elshani Astrit M. Gashi Besa Selimi Arion Elshani |
| author_sort | Brikene Elshani |
| collection | DOAJ |
| description | Harlequin ichthyosis (HI) is an extremely rare and severe genetic skin disorder characterized by thick, diamond-shaped scales covering the body, often giving the appearance of a harlequin costume. This paper provides an overview of the genetic and dermatological aspects of HI, delving into its etiology, clinical manifestations, and management. The genetic underpinnings of HI involve mutations in the ABCA12 gene, leading to impaired skin barrier function and abnormal keratinization. Understanding the molecular basis of the disorder is crucial for accurate diagnosis and potential therapeutic interventions.
Clinically, HI presents challenges related to skin integrity, thermoregulation, and potential complications, such as infections. The management of HI requires a multidisciplinary approach involving dermatologists, geneticists, and other healthcare professionals. Supportive care, including emollients, careful bathing, and prevention of infections, is essential to improve the quality of life for individuals affected by this condition.
Despite its rarity and severity, advancements in medical research and genetic therapies offer hope for improved treatments and interventions. This paper aims to contribute to the collective understanding of HI, fostering ongoing research and compassionate care for those living with this unique and challenging dermatological condition. We presented a premature eutrophic harlequin baby, born at 32+ weeks of gestation via emergency C-section. A clinical diagnosis was established minutes after birth, based on the typical features of HI, from scaly skin, marked fissures, and limbs in flexion contractures to prominent eclabium and bilateral ectropion. |
| first_indexed | 2024-03-07T16:57:49Z |
| format | Article |
| id | doaj.art-2b662e6f51064a3b9b9eb223606a47ba |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-03-07T16:57:49Z |
| publishDate | 2024-03-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-2b662e6f51064a3b9b9eb223606a47ba2024-03-03T03:38:29ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292024-03-0114118218610.21103/Article14(1)_CR7Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature ReviewBrikene Elshani0Astrit M. Gashi1Besa Selimi2Arion Elshani3Department of Obstetrics and Gynecology, University Clinical Centre of Kosovo, Faculty of Medicine, University of Prishtina, Prishtina, KosovoDepartment of Obstetrics and Gynecology, University Clinical Centre of Kosovo, Faculty of Medicine, University of Prishtina, Prishtina, KosovoFaculty of Medicine, University of Prishtina, Prishtina, KosovoFaculty of Medicine, University of Prishtina, Prishtina, KosovoHarlequin ichthyosis (HI) is an extremely rare and severe genetic skin disorder characterized by thick, diamond-shaped scales covering the body, often giving the appearance of a harlequin costume. This paper provides an overview of the genetic and dermatological aspects of HI, delving into its etiology, clinical manifestations, and management. The genetic underpinnings of HI involve mutations in the ABCA12 gene, leading to impaired skin barrier function and abnormal keratinization. Understanding the molecular basis of the disorder is crucial for accurate diagnosis and potential therapeutic interventions. Clinically, HI presents challenges related to skin integrity, thermoregulation, and potential complications, such as infections. The management of HI requires a multidisciplinary approach involving dermatologists, geneticists, and other healthcare professionals. Supportive care, including emollients, careful bathing, and prevention of infections, is essential to improve the quality of life for individuals affected by this condition. Despite its rarity and severity, advancements in medical research and genetic therapies offer hope for improved treatments and interventions. This paper aims to contribute to the collective understanding of HI, fostering ongoing research and compassionate care for those living with this unique and challenging dermatological condition. We presented a premature eutrophic harlequin baby, born at 32+ weeks of gestation via emergency C-section. A clinical diagnosis was established minutes after birth, based on the typical features of HI, from scaly skin, marked fissures, and limbs in flexion contractures to prominent eclabium and bilateral ectropion.http://www.ijbm.org/articles/i53/ijbm_14(1)_cr7.pdfharlequin ichthyosisectropionmscaly skinconsanguinityabca12 gene |
| spellingShingle | Brikene Elshani Astrit M. Gashi Besa Selimi Arion Elshani Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature Review International Journal of Biomedicine harlequin ichthyosis ectropionm scaly skin consanguinity abca12 gene |
| title | Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature Review |
| title_full | Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature Review |
| title_fullStr | Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature Review |
| title_full_unstemmed | Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature Review |
| title_short | Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature Review |
| title_sort | harlequin ichthyosis genetic and dermatological challenges a case report and literature review |
| topic | harlequin ichthyosis ectropionm scaly skin consanguinity abca12 gene |
| url | http://www.ijbm.org/articles/i53/ijbm_14(1)_cr7.pdf |
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