Effect of topical dorzolamide on rabbit central corneal thickness
Our objective was to study the effect of dorzolamide on corneal hydration in an 18-week controlled experiment using ultrasonic pachymetry. Twenty-eight male rabbits were divided randomly into four groups. The 7 rabbits in each group received eye drops containing either 2% (w/v) dorzolamide or placeb...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2006-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200015 |
| _version_ | 1819090228180156416 |
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| author | Almeida Jr. G.C. Faria e Souza S.J. |
| author_facet | Almeida Jr. G.C. Faria e Souza S.J. |
| author_sort | Almeida Jr. G.C. |
| collection | DOAJ |
| description | Our objective was to study the effect of dorzolamide on corneal hydration in an 18-week controlled experiment using ultrasonic pachymetry. Twenty-eight male rabbits were divided randomly into four groups. The 7 rabbits in each group received eye drops containing either 2% (w/v) dorzolamide or placebo in their right eye, or in their left eye. The 2% dorzolamide rabbits were treated every 8 h. Fellow eyes are defined as eyes which did not receive either dorzolamide or placebo. The study was blind for both the person who applied the drug and the one who performed the pachymetry. The effect of treatments is reported on the basis of the percentage of pachymetric variation compared to the measurement made before drug application. There was no significant difference (P = 0.061) in pachymetric variation between dorzolamide (-4.42 ± 11.71%) and placebo (2.48 ± 9.63%). However, there was a significant difference (P = 0.0034) in pachymetric variation between the dorzolamide fellow eyes (-7.56 ± 10.50%) and the placebo (-4.42 ± 11.71%). In conclusion, dorzolamide did not increase the corneal thickness in rabbits. |
| first_indexed | 2024-12-21T22:20:29Z |
| format | Article |
| id | doaj.art-2b671133f6384470aeba7ee2ef5d263b |
| institution | Directory Open Access Journal |
| issn | 0100-879X 0034-7310 |
| language | English |
| last_indexed | 2024-12-21T22:20:29Z |
| publishDate | 2006-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-2b671133f6384470aeba7ee2ef5d263b2022-12-21T18:48:20ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73102006-01-01392277281Effect of topical dorzolamide on rabbit central corneal thicknessAlmeida Jr. G.C.Faria e Souza S.J.Our objective was to study the effect of dorzolamide on corneal hydration in an 18-week controlled experiment using ultrasonic pachymetry. Twenty-eight male rabbits were divided randomly into four groups. The 7 rabbits in each group received eye drops containing either 2% (w/v) dorzolamide or placebo in their right eye, or in their left eye. The 2% dorzolamide rabbits were treated every 8 h. Fellow eyes are defined as eyes which did not receive either dorzolamide or placebo. The study was blind for both the person who applied the drug and the one who performed the pachymetry. The effect of treatments is reported on the basis of the percentage of pachymetric variation compared to the measurement made before drug application. There was no significant difference (P = 0.061) in pachymetric variation between dorzolamide (-4.42 ± 11.71%) and placebo (2.48 ± 9.63%). However, there was a significant difference (P = 0.0034) in pachymetric variation between the dorzolamide fellow eyes (-7.56 ± 10.50%) and the placebo (-4.42 ± 11.71%). In conclusion, dorzolamide did not increase the corneal thickness in rabbits.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200015DorzolamideCorneal thicknessCarbonic anhydrase inhibitionUltrasonic pachymetry |
| spellingShingle | Almeida Jr. G.C. Faria e Souza S.J. Effect of topical dorzolamide on rabbit central corneal thickness Brazilian Journal of Medical and Biological Research Dorzolamide Corneal thickness Carbonic anhydrase inhibition Ultrasonic pachymetry |
| title | Effect of topical dorzolamide on rabbit central corneal thickness |
| title_full | Effect of topical dorzolamide on rabbit central corneal thickness |
| title_fullStr | Effect of topical dorzolamide on rabbit central corneal thickness |
| title_full_unstemmed | Effect of topical dorzolamide on rabbit central corneal thickness |
| title_short | Effect of topical dorzolamide on rabbit central corneal thickness |
| title_sort | effect of topical dorzolamide on rabbit central corneal thickness |
| topic | Dorzolamide Corneal thickness Carbonic anhydrase inhibition Ultrasonic pachymetry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200015 |
| work_keys_str_mv | AT almeidajrgc effectoftopicaldorzolamideonrabbitcentralcornealthickness AT fariaesouzasj effectoftopicaldorzolamideonrabbitcentralcornealthickness |