Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care
Abstract Background Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate (ME) and severe (SE) exacerbations in asthma patients receiving outpati...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-017-0422-6 |
| _version_ | 1819092574489542656 |
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| author | Francisco Javier Álvarez Gutiérrez Marta Ferrer Galván Juan Francisco Medina Gallardo Marta Barrera Mancera Beatriz Romero Romero Auxiliadora Romero Falcón |
| author_facet | Francisco Javier Álvarez Gutiérrez Marta Ferrer Galván Juan Francisco Medina Gallardo Marta Barrera Mancera Beatriz Romero Romero Auxiliadora Romero Falcón |
| author_sort | Francisco Javier Álvarez Gutiérrez |
| collection | DOAJ |
| description | Abstract Background Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate (ME) and severe (SE) exacerbations in asthma patients receiving outpatient care. Methods Patients aged > 12 years with asthma were included in the study and followed-up at 4-monthly intervals over a 12-month period. Clinical (severity, level of control, asthma control test [ACT]), atopic, functional, inflammatory, SE and ME parameters were recorded. Univariate analysis was used to compare data from patients presenting at least 1 SE or ME during the follow-up period vs no exacerbations. Statistically significant (p <0.1) factors were then subjected to multiple analysis by binary logistic regression. Results A total of 330 patients completed the study, most of whom were atopic (76%), women (nearly 70%), with moderate and mild persistent asthma (>80%). Twenty-seven patients (8%) had a SE and 183 had a ME (58.5%) during follow-up. In the case of SEs, the only predictive factor identified in the multiple analysis was previous SE (baseline visit OR 4.218 95% CI 1.53-11.58, 4-month follow-up OR 6.88 95% CI 2.018-23.51) and inhalation technique (OR 3.572 95% CI 1.324-9.638). In the case of MEs, the only predictive factor found in the multiple analysis were previous ME (baseline visit OR 2.90 95% CI 1.54-5.48, 4-month follow- up OR 1.702 95% CI 1.146-2.529). Conclusions The primary predictive factor for SE or ME is prior SE or ME, respectively. SEs seem to constitute a specific patient "phenotype", in which the sole predictive factor is prior SEs. |
| first_indexed | 2024-12-21T22:57:47Z |
| format | Article |
| id | doaj.art-2b68573e772241d091b33e6bb27de741 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-21T22:57:47Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-2b68573e772241d091b33e6bb27de7412022-12-21T18:47:23ZengBMCBMC Pulmonary Medicine1471-24662017-05-011711710.1186/s12890-017-0422-6Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient careFrancisco Javier Álvarez Gutiérrez0Marta Ferrer Galván1Juan Francisco Medina Gallardo2Marta Barrera Mancera3Beatriz Romero Romero4Auxiliadora Romero Falcón5Asthma Unit, UMQER, Hospital Universitario Virgen del RocioAsthma Unit, UMQER, Hospital Universitario Virgen del RocioAsthma Unit, UMQER, Hospital Universitario Virgen del RocioAsthma Unit, UMQER, Hospital Universitario Virgen del RocioAsthma Unit, UMQER, Hospital Universitario Virgen del RocioAsthma Unit, UMQER, Hospital Universitario Virgen del RocioAbstract Background Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate (ME) and severe (SE) exacerbations in asthma patients receiving outpatient care. Methods Patients aged > 12 years with asthma were included in the study and followed-up at 4-monthly intervals over a 12-month period. Clinical (severity, level of control, asthma control test [ACT]), atopic, functional, inflammatory, SE and ME parameters were recorded. Univariate analysis was used to compare data from patients presenting at least 1 SE or ME during the follow-up period vs no exacerbations. Statistically significant (p <0.1) factors were then subjected to multiple analysis by binary logistic regression. Results A total of 330 patients completed the study, most of whom were atopic (76%), women (nearly 70%), with moderate and mild persistent asthma (>80%). Twenty-seven patients (8%) had a SE and 183 had a ME (58.5%) during follow-up. In the case of SEs, the only predictive factor identified in the multiple analysis was previous SE (baseline visit OR 4.218 95% CI 1.53-11.58, 4-month follow-up OR 6.88 95% CI 2.018-23.51) and inhalation technique (OR 3.572 95% CI 1.324-9.638). In the case of MEs, the only predictive factor found in the multiple analysis were previous ME (baseline visit OR 2.90 95% CI 1.54-5.48, 4-month follow- up OR 1.702 95% CI 1.146-2.529). Conclusions The primary predictive factor for SE or ME is prior SE or ME, respectively. SEs seem to constitute a specific patient "phenotype", in which the sole predictive factor is prior SEs.http://link.springer.com/article/10.1186/s12890-017-0422-6Asthma managementAsthma control testAtopicFunctional and inflammatory parametersDisease controlPredictive factors for exacerbations |
| spellingShingle | Francisco Javier Álvarez Gutiérrez Marta Ferrer Galván Juan Francisco Medina Gallardo Marta Barrera Mancera Beatriz Romero Romero Auxiliadora Romero Falcón Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care BMC Pulmonary Medicine Asthma management Asthma control test Atopic Functional and inflammatory parameters Disease control Predictive factors for exacerbations |
| title | Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care |
| title_full | Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care |
| title_fullStr | Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care |
| title_full_unstemmed | Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care |
| title_short | Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care |
| title_sort | predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care |
| topic | Asthma management Asthma control test Atopic Functional and inflammatory parameters Disease control Predictive factors for exacerbations |
| url | http://link.springer.com/article/10.1186/s12890-017-0422-6 |
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