DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors

DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors

Fused in sarcoma/translated in liposarcoma (FUS) is an RNA-binding protein, and its mutations are associated with neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), through the DNA damage stress response, aberrant stress granule (SG) formation, etc. We previously reported tha...

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Bibliographic Details
Main Authors: Masahiro Nogami, Osamu Sano, Keiko Adachi-Tominari, Yoshika Hayakawa-Yano, Takako Furukawa, Hidehisa Iwata, Kazuhiro Ogi, Hideyuki Okano, Masato Yano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
FUS
stress granule
amyotrophic lateral scelerosis
compound library screening
RNA-binding protein
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.953365/full

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