Ring generator of neuron-like activity with tunable frequency
The aim of the work is to build a radiophysical generator of neuron-like activity with a frequency tunable in various ways, corresponding to modern ideas about the structure of the hippocampus and the generation of pathological epileptic rhythms in it. Methods. The elements of the generator are radi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Saratov State University
2023-01-01
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| Series: | Известия высших учебных заведений: Прикладная нелинейная динамика |
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| Online Access: | https://andjournal.sgu.ru/sites/andjournal.sgu.ru/files/text-pdf/2022/12/and_2023_egorov-et-al.pdf |
| _version_ | 1797938731757338624 |
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| author | Egorov, Nikita Mikhailovich Sysoeva, Marina Vyacheslavovna Ponomarenko, Vladimir Ivanovich Kornilov, Maksim Vyacheslavovich Sysoev, Ilya Vyacheslavovich |
| author_facet | Egorov, Nikita Mikhailovich Sysoeva, Marina Vyacheslavovna Ponomarenko, Vladimir Ivanovich Kornilov, Maksim Vyacheslavovich Sysoev, Ilya Vyacheslavovich |
| author_sort | Egorov, Nikita Mikhailovich |
| collection | DOAJ |
| description | The aim of the work is to build a radiophysical generator of neuron-like activity with a frequency tunable in various ways, corresponding to modern ideas about the structure of the hippocampus and the generation of pathological epileptic rhythms in it. Methods. The elements of the generator are radio engineering implementations of the complete FitzHugh– Nagumo neuron and the electronic implementation of a chemical synapse in the form of a sigmoid function with a delayed argument. The simulation was carried out in the SPICE simulator. Results. Various ways of introducing delay into the coupling are considered: an ideal delay line, a phase filter with a rheostat, one tunable Bessel filter, and a sequence of non-tunable Bessel filters. For circuit implementation, the approach using a Bessel filter with a rheostat is recognized as optimal as a compromise between simplicity and minimization of signal distortion. The dependences of the oscillation frequency on the number of elements in the ring and the delay time are constructed. The bistability of generation regimes is studied for certain values of the parameters. The effect of inclusion of inhibitory elements (interneurons) in the circuit is considered. Conclusion. The constructed ring generator models the experimentally observed properties of the dynamics of epileptic discharge fundamental frequency in limbic epilepsy. It is able to reproduce the occurrence of oscillations as a result of external short-term driving, smooth and sharp frequency tuning, the coexistence of different modes with the same parameters. |
| first_indexed | 2024-04-10T19:04:16Z |
| format | Article |
| id | doaj.art-2b68935e67374cd99357b56573c6bf85 |
| institution | Directory Open Access Journal |
| issn | 0869-6632 2542-1905 |
| language | English |
| last_indexed | 2024-04-10T19:04:16Z |
| publishDate | 2023-01-01 |
| publisher | Saratov State University |
| record_format | Article |
| series | Известия высших учебных заведений: Прикладная нелинейная динамика |
| spelling | doaj.art-2b68935e67374cd99357b56573c6bf852023-01-31T04:41:44ZengSaratov State UniversityИзвестия высших учебных заведений: Прикладная нелинейная динамика0869-66322542-19052023-01-0131110312010.18500/0869-6632-003025Ring generator of neuron-like activity with tunable frequencyEgorov, Nikita Mikhailovich0Sysoeva, Marina Vyacheslavovna1Ponomarenko, Vladimir Ivanovich2Kornilov, Maksim Vyacheslavovich3Sysoev, Ilya Vyacheslavovich4Yuri Gagarin State Technical University of Saratov, ul. Politechnicheskaya, 77, Saratov, 410054, RussiaYuri Gagarin State Technical University of Saratov, ul. Politechnicheskaya, 77, Saratov, 410054, RussiaSaratov Branch of Kotel`nikov Institute of Radiophysics and Electronics of Russian Academy of Sciences, ul. Zelyonaya, 38, Saratov, 410019, RussiaSaratov State University, ul. Astrakhanskaya, 83, Saratov, 410012, RussiaSaratov State University, ul. Astrakhanskaya, 83, Saratov, 410012, RussiaThe aim of the work is to build a radiophysical generator of neuron-like activity with a frequency tunable in various ways, corresponding to modern ideas about the structure of the hippocampus and the generation of pathological epileptic rhythms in it. Methods. The elements of the generator are radio engineering implementations of the complete FitzHugh– Nagumo neuron and the electronic implementation of a chemical synapse in the form of a sigmoid function with a delayed argument. The simulation was carried out in the SPICE simulator. Results. Various ways of introducing delay into the coupling are considered: an ideal delay line, a phase filter with a rheostat, one tunable Bessel filter, and a sequence of non-tunable Bessel filters. For circuit implementation, the approach using a Bessel filter with a rheostat is recognized as optimal as a compromise between simplicity and minimization of signal distortion. The dependences of the oscillation frequency on the number of elements in the ring and the delay time are constructed. The bistability of generation regimes is studied for certain values of the parameters. The effect of inclusion of inhibitory elements (interneurons) in the circuit is considered. Conclusion. The constructed ring generator models the experimentally observed properties of the dynamics of epileptic discharge fundamental frequency in limbic epilepsy. It is able to reproduce the occurrence of oscillations as a result of external short-term driving, smooth and sharp frequency tuning, the coexistence of different modes with the same parameters.https://andjournal.sgu.ru/sites/andjournal.sgu.ru/files/text-pdf/2022/12/and_2023_egorov-et-al.pdffitzhugh–nagumo neuron electronic circuitneural networktime delayed systemssigmoid coupling |
| spellingShingle | Egorov, Nikita Mikhailovich Sysoeva, Marina Vyacheslavovna Ponomarenko, Vladimir Ivanovich Kornilov, Maksim Vyacheslavovich Sysoev, Ilya Vyacheslavovich Ring generator of neuron-like activity with tunable frequency Известия высших учебных заведений: Прикладная нелинейная динамика fitzhugh–nagumo neuron electronic circuit neural network time delayed systems sigmoid coupling |
| title | Ring generator of neuron-like activity with tunable frequency |
| title_full | Ring generator of neuron-like activity with tunable frequency |
| title_fullStr | Ring generator of neuron-like activity with tunable frequency |
| title_full_unstemmed | Ring generator of neuron-like activity with tunable frequency |
| title_short | Ring generator of neuron-like activity with tunable frequency |
| title_sort | ring generator of neuron like activity with tunable frequency |
| topic | fitzhugh–nagumo neuron electronic circuit neural network time delayed systems sigmoid coupling |
| url | https://andjournal.sgu.ru/sites/andjournal.sgu.ru/files/text-pdf/2022/12/and_2023_egorov-et-al.pdf |
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