Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials
Background and aims: Metabolic diseases are globally popular, and a systematic review and meta-analysis of turmeric and curcuminoids on glucose metabolism among people with metabolic diseases was performed. Design: We comprehensively searched Web of Science, PubMed, Ovid (including EMBASE and MEDLIN...
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Elsevier
2022-03-01
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Series: | Pharmacological Research |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661822000664 |
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author | Fen Yuan Wenbin Wu Leyi Ma Dingkun Wang Meilin Hu Jing Gong Ke Fang Lijun Xu Hui Dong Fuer Lu |
author_facet | Fen Yuan Wenbin Wu Leyi Ma Dingkun Wang Meilin Hu Jing Gong Ke Fang Lijun Xu Hui Dong Fuer Lu |
author_sort | Fen Yuan |
collection | DOAJ |
description | Background and aims: Metabolic diseases are globally popular, and a systematic review and meta-analysis of turmeric and curcuminoids on glucose metabolism among people with metabolic diseases was performed. Design: We comprehensively searched Web of Science, PubMed, Ovid (including EMBASE and MEDLINE), Scopus, the Cochrane Library and two Chinese databases, Wanfang and CNKI for RCTs that focused on the effects of turmeric and curcuminoids on fasting blood glucose (FBG), hemoglobin A1C (HbA1c), fasting serum insulin (FSI) and HOMA-IR among patients with metabolic diseases. The FBG and HbA1c were the main outcomes to be analyzed. With random-effects models, separate meta-analyses were conducted by inverse-variance and reported as WMD with 95% CIs. Results: Evidence from 17 RCTs including 22 trials showed that turmeric and curcuminoids lowered FBG by − 7.86 mg/dL (95% CI: −12.04, −3.67 mg/dL; P = 0.0002), HbA1c by − 0.38% (95% CI: −0.52%, −0.23%; P < 0.00001) and HOMA-IR by − 1.01 (95% CI: −1.6, −0.42; P = 0.0008). Moreover, they decreased fasting serum insulin by − 1.69 mU/L (95% CI: −3.22, −0.16 mU/L; P = 0.03) after more than 8 weeks of intervention in a subgroup analysis. Conclusions: Turmeric and curcuminiods decrease FBG, HbA1c and HOMA-IR significantly among subjects with metabolic disease. Additionally, they may have an effect on FSI concentrations if the intervention period is more than 8 weeks. However, attention should be paid to these outcomes due to the significant heterogeneity. |
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issn | 1096-1186 |
language | English |
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publishDate | 2022-03-01 |
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series | Pharmacological Research |
spelling | doaj.art-2b68fb02f38a4bc3a8c5be5e86f0955c2024-01-04T04:36:28ZengElsevierPharmacological Research1096-11862022-03-01177106121Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trialsFen Yuan0Wenbin Wu1Leyi Ma2Dingkun Wang3Meilin Hu4Jing Gong5Ke Fang6Lijun Xu7Hui Dong8Fuer Lu9Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaInstitution of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaInstitution of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, China; Corresponding author.Background and aims: Metabolic diseases are globally popular, and a systematic review and meta-analysis of turmeric and curcuminoids on glucose metabolism among people with metabolic diseases was performed. Design: We comprehensively searched Web of Science, PubMed, Ovid (including EMBASE and MEDLINE), Scopus, the Cochrane Library and two Chinese databases, Wanfang and CNKI for RCTs that focused on the effects of turmeric and curcuminoids on fasting blood glucose (FBG), hemoglobin A1C (HbA1c), fasting serum insulin (FSI) and HOMA-IR among patients with metabolic diseases. The FBG and HbA1c were the main outcomes to be analyzed. With random-effects models, separate meta-analyses were conducted by inverse-variance and reported as WMD with 95% CIs. Results: Evidence from 17 RCTs including 22 trials showed that turmeric and curcuminoids lowered FBG by − 7.86 mg/dL (95% CI: −12.04, −3.67 mg/dL; P = 0.0002), HbA1c by − 0.38% (95% CI: −0.52%, −0.23%; P < 0.00001) and HOMA-IR by − 1.01 (95% CI: −1.6, −0.42; P = 0.0008). Moreover, they decreased fasting serum insulin by − 1.69 mU/L (95% CI: −3.22, −0.16 mU/L; P = 0.03) after more than 8 weeks of intervention in a subgroup analysis. Conclusions: Turmeric and curcuminiods decrease FBG, HbA1c and HOMA-IR significantly among subjects with metabolic disease. Additionally, they may have an effect on FSI concentrations if the intervention period is more than 8 weeks. However, attention should be paid to these outcomes due to the significant heterogeneity.http://www.sciencedirect.com/science/article/pii/S1043661822000664CurcuminiodsGlycometabolismMeta-analysisMetabolic diseasesTurmeric |
spellingShingle | Fen Yuan Wenbin Wu Leyi Ma Dingkun Wang Meilin Hu Jing Gong Ke Fang Lijun Xu Hui Dong Fuer Lu Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials Pharmacological Research Curcuminiods Glycometabolism Meta-analysis Metabolic diseases Turmeric |
title | Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials |
title_full | Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials |
title_fullStr | Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials |
title_full_unstemmed | Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials |
title_short | Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials |
title_sort | turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases a systematic review and meta analysis of randomized controlled trials |
topic | Curcuminiods Glycometabolism Meta-analysis Metabolic diseases Turmeric |
url | http://www.sciencedirect.com/science/article/pii/S1043661822000664 |
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