Research progress of HIV-associated myelopathy
<p>The wide usage of highly active antiretroviral therapy (HAART) leads to reduction of the occurence rate of focal or diffuse neurological damage caused by human immunodeficiency virus (HIV) infection, which prominently improves the living quality of HIV-infected patients. Despite this pro...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2016-08-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/1439 |
| _version_ | 1828842866421530624 |
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| author | Kun HONG Chang LIU Zhao-hua MENG Hua YIN Jun-ying HE |
| author_facet | Kun HONG Chang LIU Zhao-hua MENG Hua YIN Jun-ying HE |
| author_sort | Kun HONG |
| collection | DOAJ |
| description | <p>The wide usage of highly active antiretroviral therapy (HAART) leads to reduction of the occurence rate of focal or diffuse neurological damage caused by human immunodeficiency virus (HIV) infection, which prominently improves the living quality of HIV-infected patients. Despite this progress, about 70% of HIV-infected patients develop neurological complications. Although neurological disease typically occurs in the advanced stage of the disease or after severe damage of immune functions, it may also occur during early stage of the infection. HIV-associated myelopathy is a common complication of immunodeficiency syndrome and its typical pathological appearence is vacuolar degeneration. In many patients the clinical manifestations of vacuolar myelopathy are in fact limited to non-specific sphincter or sexual dysfunction, and may remain completely asymptomatic. Even when motor and sensory symptoms become evident, the diagnosis is often complicated by a concomitant peripheral neuropathy. The purpose of this study is to summarize pathogenesis, clinical manifestations, pathological features, diagnosis and treatment of HIV-associated myelopathy.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.08.004</p> |
| first_indexed | 2024-12-12T20:33:43Z |
| format | Article |
| id | doaj.art-2b6906df81fe4d90a3f5461cecbf07bb |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-12T20:33:43Z |
| publishDate | 2016-08-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-2b6906df81fe4d90a3f5461cecbf07bb2022-12-22T00:12:57ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312016-08-011684814841417Research progress of HIV-associated myelopathyKun HONG0Chang LIU1Zhao-hua MENG2Hua YIN3Jun-ying HE4Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, ChinaDepartment of Rehabilitation, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, ChinaDepartment of Emergency, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, ChinaDepartment of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, ChinaDepartment of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China<p>The wide usage of highly active antiretroviral therapy (HAART) leads to reduction of the occurence rate of focal or diffuse neurological damage caused by human immunodeficiency virus (HIV) infection, which prominently improves the living quality of HIV-infected patients. Despite this progress, about 70% of HIV-infected patients develop neurological complications. Although neurological disease typically occurs in the advanced stage of the disease or after severe damage of immune functions, it may also occur during early stage of the infection. HIV-associated myelopathy is a common complication of immunodeficiency syndrome and its typical pathological appearence is vacuolar degeneration. In many patients the clinical manifestations of vacuolar myelopathy are in fact limited to non-specific sphincter or sexual dysfunction, and may remain completely asymptomatic. Even when motor and sensory symptoms become evident, the diagnosis is often complicated by a concomitant peripheral neuropathy. The purpose of this study is to summarize pathogenesis, clinical manifestations, pathological features, diagnosis and treatment of HIV-associated myelopathy.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.08.004</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1439HIVSpinal cord diseasesReview |
| spellingShingle | Kun HONG Chang LIU Zhao-hua MENG Hua YIN Jun-ying HE Research progress of HIV-associated myelopathy Chinese Journal of Contemporary Neurology and Neurosurgery HIV Spinal cord diseases Review |
| title | Research progress of HIV-associated myelopathy |
| title_full | Research progress of HIV-associated myelopathy |
| title_fullStr | Research progress of HIV-associated myelopathy |
| title_full_unstemmed | Research progress of HIV-associated myelopathy |
| title_short | Research progress of HIV-associated myelopathy |
| title_sort | research progress of hiv associated myelopathy |
| topic | HIV Spinal cord diseases Review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/1439 |
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