Negative effect of high-level infrasound on human myocardial contractility: In-vitro controlled experiment
Background: Human exposure to infrasound is increasing due to man-made factors, such as occupational conditions, wind farms and transportation. The concern among the public regarding the safety of infrasound exposure is growing. Aims: To evaluate whether exposure to infrasound interferes directly wi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Noise and Health |
| Subjects: | |
| Online Access: | http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2021;volume=23;issue=109;spage=57;epage=66;aulast=Chaban |
| _version_ | 1830354284237029376 |
|---|---|
| author | Ryan Chaban Ahmed Ghazy Eleni Georgiade Nicole Stumpf Christian-Friedrich Vahl |
| author_facet | Ryan Chaban Ahmed Ghazy Eleni Georgiade Nicole Stumpf Christian-Friedrich Vahl |
| author_sort | Ryan Chaban |
| collection | DOAJ |
| description | Background: Human exposure to infrasound is increasing due to man-made factors, such as occupational conditions, wind farms and transportation. The concern among the public regarding the safety of infrasound exposure is growing. Aims: To evaluate whether exposure to infrasound interferes directly with human cardiac function and contributes to pathological processes. Setting: The University Hospital of Mainz, Germany. Methods: Human myocardial tissues, obtained from patients undergoing cardiac surgery, were prepared in small muscle samples and stimulated electrically in-vitro for a period of almost two hours under physiological conditions to induce continuous pulsatile contractions and simulating a working human heart. Two samples were obtained from each donor: one was subjected to infrasound for 60 min and the other served as a control. Their contraction forces (CF) and durations (CD) were measured before and after each testing period and their relative changes (CF% and CD%) were calculated and introduced in a multilinear regression model. The following three infrasound levels of exposure were used in this study: 100, 110 and 120 dBz. Results: The measured CF% corresponded negatively with the infrasound level measured in dBz (R2 = 0.631; P = 0.018). The decrease measured almost −11% at 110 dBz and −18% at 120 dBz, after correction for control. The CD on the other hand remained unchanged. Conclusions: Exposure to high levels of infrasound (more than 100 dBz) interferes with cardiac muscle contractile ability, as early as one hour after exposure. There are numerous additional studies which support this conclusion. These results should be taken into account when considering environmental regulations. |
| first_indexed | 2024-12-20T01:29:12Z |
| format | Article |
| id | doaj.art-2b6bd769a3ff4c6f8268aeb28bb2bbcd |
| institution | Directory Open Access Journal |
| issn | 1463-1741 1998-4030 |
| language | English |
| last_indexed | 2024-12-20T01:29:12Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Noise and Health |
| spelling | doaj.art-2b6bd769a3ff4c6f8268aeb28bb2bbcd2022-12-21T19:58:10ZengWolters Kluwer Medknow PublicationsNoise and Health1463-17411998-40302021-01-0123109576610.4103/nah.NAH_28_19Negative effect of high-level infrasound on human myocardial contractility: In-vitro controlled experimentRyan ChabanAhmed GhazyEleni GeorgiadeNicole StumpfChristian-Friedrich VahlBackground: Human exposure to infrasound is increasing due to man-made factors, such as occupational conditions, wind farms and transportation. The concern among the public regarding the safety of infrasound exposure is growing. Aims: To evaluate whether exposure to infrasound interferes directly with human cardiac function and contributes to pathological processes. Setting: The University Hospital of Mainz, Germany. Methods: Human myocardial tissues, obtained from patients undergoing cardiac surgery, were prepared in small muscle samples and stimulated electrically in-vitro for a period of almost two hours under physiological conditions to induce continuous pulsatile contractions and simulating a working human heart. Two samples were obtained from each donor: one was subjected to infrasound for 60 min and the other served as a control. Their contraction forces (CF) and durations (CD) were measured before and after each testing period and their relative changes (CF% and CD%) were calculated and introduced in a multilinear regression model. The following three infrasound levels of exposure were used in this study: 100, 110 and 120 dBz. Results: The measured CF% corresponded negatively with the infrasound level measured in dBz (R2 = 0.631; P = 0.018). The decrease measured almost −11% at 110 dBz and −18% at 120 dBz, after correction for control. The CD on the other hand remained unchanged. Conclusions: Exposure to high levels of infrasound (more than 100 dBz) interferes with cardiac muscle contractile ability, as early as one hour after exposure. There are numerous additional studies which support this conclusion. These results should be taken into account when considering environmental regulations.http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2021;volume=23;issue=109;spage=57;epage=66;aulast=Chabanenvironmental legislationheartinfrasoundlaboratory researchkey messages |
| spellingShingle | Ryan Chaban Ahmed Ghazy Eleni Georgiade Nicole Stumpf Christian-Friedrich Vahl Negative effect of high-level infrasound on human myocardial contractility: In-vitro controlled experiment Noise and Health environmental legislation heart infrasound laboratory researchkey messages |
| title | Negative effect of high-level infrasound on human myocardial contractility: In-vitro controlled experiment |
| title_full | Negative effect of high-level infrasound on human myocardial contractility: In-vitro controlled experiment |
| title_fullStr | Negative effect of high-level infrasound on human myocardial contractility: In-vitro controlled experiment |
| title_full_unstemmed | Negative effect of high-level infrasound on human myocardial contractility: In-vitro controlled experiment |
| title_short | Negative effect of high-level infrasound on human myocardial contractility: In-vitro controlled experiment |
| title_sort | negative effect of high level infrasound on human myocardial contractility in vitro controlled experiment |
| topic | environmental legislation heart infrasound laboratory researchkey messages |
| url | http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2021;volume=23;issue=109;spage=57;epage=66;aulast=Chaban |
| work_keys_str_mv | AT ryanchaban negativeeffectofhighlevelinfrasoundonhumanmyocardialcontractilityinvitrocontrolledexperiment AT ahmedghazy negativeeffectofhighlevelinfrasoundonhumanmyocardialcontractilityinvitrocontrolledexperiment AT elenigeorgiade negativeeffectofhighlevelinfrasoundonhumanmyocardialcontractilityinvitrocontrolledexperiment AT nicolestumpf negativeeffectofhighlevelinfrasoundonhumanmyocardialcontractilityinvitrocontrolledexperiment AT christianfriedrichvahl negativeeffectofhighlevelinfrasoundonhumanmyocardialcontractilityinvitrocontrolledexperiment |