Capillary Leak Syndrome From Rituximab Therapy of Lymphoma
Capillary leak syndrome (CLS) is characterized by plasma extravasation into the interstitium with resultant hypotension, anasarca, hemoconcentration, and hypoalbuminemia in the absence of albuminuria. Initially reported in Clarkson’s disease (systemic capillary leak syndrome), CLS has been observed...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-07-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709620942372 |
| _version_ | 1818127329771126784 |
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| author | Krishna Vedala MD, MPH Sai Prasad Desikan MD Charles McClain MD Diana Jacob MD Raman Desikan MD |
| author_facet | Krishna Vedala MD, MPH Sai Prasad Desikan MD Charles McClain MD Diana Jacob MD Raman Desikan MD |
| author_sort | Krishna Vedala MD, MPH |
| collection | DOAJ |
| description | Capillary leak syndrome (CLS) is characterized by plasma extravasation into the interstitium with resultant hypotension, anasarca, hemoconcentration, and hypoalbuminemia in the absence of albuminuria. Initially reported in Clarkson’s disease (systemic capillary leak syndrome), CLS has been observed in multiple disease settings, the most common being sepsis. In oncology, CLS has been reported more often as a complication from therapy, and less often from malignancy. In this case study, we documented clinical manifestation, laboratory features, and radiological findings of CLS from rituximab therapy when employed in combination with a multi-agent chemotherapy regimen (EPOCH-R). Differentiating drug-induced CLS from sepsis, which presents with the same clinical features, is important in avoiding further exposure to rituximab, which could be fatal to the patient. |
| first_indexed | 2024-12-11T07:15:38Z |
| format | Article |
| id | doaj.art-2b6e5ba975904ee8940f920c7644ba8f |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-11T07:15:38Z |
| publishDate | 2020-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-2b6e5ba975904ee8940f920c7644ba8f2022-12-22T01:16:14ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962020-07-01810.1177/2324709620942372Capillary Leak Syndrome From Rituximab Therapy of LymphomaKrishna Vedala MD, MPH0Sai Prasad Desikan MD1Charles McClain MD2Diana Jacob MD3Raman Desikan MD4White River Health Systems, Batesville, AR, USAWhite River Health Systems, Batesville, AR, USAWhite River Health Systems, Batesville, AR, USAWhite River Health Systems, Batesville, AR, USAWhite River Health Systems, Batesville, AR, USACapillary leak syndrome (CLS) is characterized by plasma extravasation into the interstitium with resultant hypotension, anasarca, hemoconcentration, and hypoalbuminemia in the absence of albuminuria. Initially reported in Clarkson’s disease (systemic capillary leak syndrome), CLS has been observed in multiple disease settings, the most common being sepsis. In oncology, CLS has been reported more often as a complication from therapy, and less often from malignancy. In this case study, we documented clinical manifestation, laboratory features, and radiological findings of CLS from rituximab therapy when employed in combination with a multi-agent chemotherapy regimen (EPOCH-R). Differentiating drug-induced CLS from sepsis, which presents with the same clinical features, is important in avoiding further exposure to rituximab, which could be fatal to the patient.https://doi.org/10.1177/2324709620942372 |
| spellingShingle | Krishna Vedala MD, MPH Sai Prasad Desikan MD Charles McClain MD Diana Jacob MD Raman Desikan MD Capillary Leak Syndrome From Rituximab Therapy of Lymphoma Journal of Investigative Medicine High Impact Case Reports |
| title | Capillary Leak Syndrome From Rituximab Therapy of Lymphoma |
| title_full | Capillary Leak Syndrome From Rituximab Therapy of Lymphoma |
| title_fullStr | Capillary Leak Syndrome From Rituximab Therapy of Lymphoma |
| title_full_unstemmed | Capillary Leak Syndrome From Rituximab Therapy of Lymphoma |
| title_short | Capillary Leak Syndrome From Rituximab Therapy of Lymphoma |
| title_sort | capillary leak syndrome from rituximab therapy of lymphoma |
| url | https://doi.org/10.1177/2324709620942372 |
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