Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010
Objective: To examine the patterns of antituberculous drug resistance of Mycobacterium tuberculosis in patients with pulmonary and extra-pulmonary tuberculosis in the Eastern province of the Kingdom of Saudi Arabia. Methods: This is a retrospective study of antibiotic susceptibility of 1681 non-rep...
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| Format: | Article |
| Language: | English |
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Springer
2019-04-01
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| Series: | Journal of Epidemiology and Global Health |
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| Online Access: | https://www.atlantis-press.com/article/125905889/view |
| _version_ | 1817980161181614080 |
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| author | Liaqat Ali Chaudhry Nagamani Rambhala Ali Saad Al-Shammri Jaffar A. Al-Tawfiq |
| author_facet | Liaqat Ali Chaudhry Nagamani Rambhala Ali Saad Al-Shammri Jaffar A. Al-Tawfiq |
| author_sort | Liaqat Ali Chaudhry |
| collection | DOAJ |
| description | Objective: To examine the patterns of antituberculous drug resistance of Mycobacterium tuberculosis in patients with pulmonary and extra-pulmonary tuberculosis in the Eastern province of the Kingdom of Saudi Arabia.
Methods: This is a retrospective study of antibiotic susceptibility of 1681 non-repetitive M. tuberculosis isolates from 1/2003 to 6/2010.
Results: Of the total patients, 41% (n = 687) were Saudis and 59% (n = 994) were non-Saudis. The pulmonary and extra-pulmonary specimens constituted 68% (n = 1148) and 32% (n = 533), respectively. The incidence of resistance was 15.5% to one or more of anti-tuberculosis drugs. The resistance rates to first-line drugs were as follows: streptomycin (10.4%), INH (9.8%), rifampicin (1.5%) and ethambutol (1.0%). Multi-drug resistant tuberculosis was present in 1.4% (n = 24) of the sample.
Conclusion: INH resistance in this study was relatively high, whereas the rate of MDR-TB was low. A rate of MDR-TB observed in this study was 1.4%. Thus, an empiric four-drug therapy is required to treat patients with tuberculosis in this area of Saudi Arabia. |
| first_indexed | 2024-04-13T22:50:03Z |
| format | Article |
| id | doaj.art-2b6f5c85dbe341a0870a09f45f28122a |
| institution | Directory Open Access Journal |
| issn | 2210-6006 |
| language | English |
| last_indexed | 2024-04-13T22:50:03Z |
| publishDate | 2019-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Epidemiology and Global Health |
| spelling | doaj.art-2b6f5c85dbe341a0870a09f45f28122a2022-12-22T02:26:12ZengSpringerJournal of Epidemiology and Global Health2210-60062019-04-012110.1016/j.jegh.2011.10.001Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010Liaqat Ali ChaudhryNagamani RambhalaAli Saad Al-ShammriJaffar A. Al-TawfiqObjective: To examine the patterns of antituberculous drug resistance of Mycobacterium tuberculosis in patients with pulmonary and extra-pulmonary tuberculosis in the Eastern province of the Kingdom of Saudi Arabia. Methods: This is a retrospective study of antibiotic susceptibility of 1681 non-repetitive M. tuberculosis isolates from 1/2003 to 6/2010. Results: Of the total patients, 41% (n = 687) were Saudis and 59% (n = 994) were non-Saudis. The pulmonary and extra-pulmonary specimens constituted 68% (n = 1148) and 32% (n = 533), respectively. The incidence of resistance was 15.5% to one or more of anti-tuberculosis drugs. The resistance rates to first-line drugs were as follows: streptomycin (10.4%), INH (9.8%), rifampicin (1.5%) and ethambutol (1.0%). Multi-drug resistant tuberculosis was present in 1.4% (n = 24) of the sample. Conclusion: INH resistance in this study was relatively high, whereas the rate of MDR-TB was low. A rate of MDR-TB observed in this study was 1.4%. Thus, an empiric four-drug therapy is required to treat patients with tuberculosis in this area of Saudi Arabia.https://www.atlantis-press.com/article/125905889/viewIncidencePrevalenceResistanceEastern Saudi ArabiaTuberculosis |
| spellingShingle | Liaqat Ali Chaudhry Nagamani Rambhala Ali Saad Al-Shammri Jaffar A. Al-Tawfiq Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010 Journal of Epidemiology and Global Health Incidence Prevalence Resistance Eastern Saudi Arabia Tuberculosis |
| title | Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010 |
| title_full | Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010 |
| title_fullStr | Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010 |
| title_full_unstemmed | Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010 |
| title_short | Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010 |
| title_sort | patterns of antituberculous drug resistance in eastern saudi arabia a 7 year surveillance study from 1 2003 to 6 2010 |
| topic | Incidence Prevalence Resistance Eastern Saudi Arabia Tuberculosis |
| url | https://www.atlantis-press.com/article/125905889/view |
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