External beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervix
Background: Cervical carcinoma is the second most common neoplasm in women worldwide and is the most frequent cancer among women in Bangladesh. In recent years, High Dose Rate (HDR) brachytherapy in combination with External Beam Radiotherapy (EBRT) has been popular in the management of cancers of u...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bangabandhu Sheikh Mujib Medical University
2016-08-01
|
| Series: | Bangabandhu Sheikh Mujib Medical University Journal |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BSMMUJ/article/view/29143 |
| _version_ | 1811330064612065280 |
|---|---|
| author | Md. Zillur Rahman Bhuiyan Atiar Rahman Sarwar Alam Sheikh Saiful Islam Shaheen Md. Ashadul lslam S. K. Golam Mostafa |
| author_facet | Md. Zillur Rahman Bhuiyan Atiar Rahman Sarwar Alam Sheikh Saiful Islam Shaheen Md. Ashadul lslam S. K. Golam Mostafa |
| author_sort | Md. Zillur Rahman Bhuiyan |
| collection | DOAJ |
| description | Background: Cervical carcinoma is the second most common neoplasm in women worldwide and is the most frequent cancer among women in Bangladesh. In recent years, High Dose Rate (HDR) brachytherapy in combination with External Beam Radiotherapy (EBRT) has been popular in the management of cancers of uterine cervix.
Objectives: To evaluate the effectiveness and acute toxicity of four fractions high dose rate intracavitary brachytherapy following pelvic external beam radiotherapy in the treatment of locally advanced cervical carcinoma.
Methods: Bangabandhu Sheikh Mujib Medical University & NICRH chosen as a research place for EBRT and HOR brachytherapy. A typical radiotherapy treatment involves daily inadiation for several weeks. Whole pelvis was treated with total dose of SO Gy in 5 weeks. Patients were treated once a day, 5 days a week with a daily fraction size of 2.0 Gy. EBRT: Pelvic radiotherapy dose is 50 Gy in 25 fractions (2.0 Gy per fraction) over 5 weeks. HDR brachytberapy dose is 7 Gy per fraction, total 4 fractions, each in a week over 4 weeks.
Results: Ninety-eight patients were entered in the study. Three patients were excluded due to active non-malignant diseases. One patient had active tuberculosis, two patients had severe skin reactions and two patients withdrew following the first HDR application. The remaining Ninety patients were analyzed. Ninety patients completed the prescribed treatment and were evaluated. Eighty had complete response with relief of symptoms, negative Pap-smear and no clinical signs of persistence disease at 3 months. Ten patients had a positive Pap-smear with clinical signs of persistence disease. Patients were evaluated before statting treatment with EBRT and before starting treatment with HDR ICBT.
Conclusion: It can be easily concluded that 4 fractions of HDR ICBT, 7 Gy each weekly and pelvic EBRT can effectively and safely control locally advanced carcinoma of the uterine cervix. So that EBRT and HDR ICBT is an acceptable treatment for locally advanced carcinoma of the uterine cervix. Careful attention to normal tissue doses such as the rectum, bladder, and small bowel is important in the treatment of locally advanced cervical cancer. |
| first_indexed | 2024-04-13T15:56:02Z |
| format | Article |
| id | doaj.art-2b7055b22f9146a29abd3a88225c134b |
| institution | Directory Open Access Journal |
| issn | 2074-2908 2224-7750 |
| language | English |
| last_indexed | 2024-04-13T15:56:02Z |
| publishDate | 2016-08-01 |
| publisher | Bangabandhu Sheikh Mujib Medical University |
| record_format | Article |
| series | Bangabandhu Sheikh Mujib Medical University Journal |
| spelling | doaj.art-2b7055b22f9146a29abd3a88225c134b2022-12-22T02:40:42ZengBangabandhu Sheikh Mujib Medical UniversityBangabandhu Sheikh Mujib Medical University Journal2074-29082224-77502016-08-017110.3329/bsmmuj.v7i1.2914318740External beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervixMd. Zillur Rahman Bhuiyan0Atiar Rahman1Sarwar Alam2Sheikh Saiful Islam Shaheen3Md. Ashadul lslam4S. K. Golam Mostafa5Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, DhakaDepartment of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, DhakaDepartment of Oncology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, DhakaDepartment of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, DhakaDepartment of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, DhakaDepartment of Transfusion Medicine, National Institute of Cancer ResearchBackground: Cervical carcinoma is the second most common neoplasm in women worldwide and is the most frequent cancer among women in Bangladesh. In recent years, High Dose Rate (HDR) brachytherapy in combination with External Beam Radiotherapy (EBRT) has been popular in the management of cancers of uterine cervix. Objectives: To evaluate the effectiveness and acute toxicity of four fractions high dose rate intracavitary brachytherapy following pelvic external beam radiotherapy in the treatment of locally advanced cervical carcinoma. Methods: Bangabandhu Sheikh Mujib Medical University & NICRH chosen as a research place for EBRT and HOR brachytherapy. A typical radiotherapy treatment involves daily inadiation for several weeks. Whole pelvis was treated with total dose of SO Gy in 5 weeks. Patients were treated once a day, 5 days a week with a daily fraction size of 2.0 Gy. EBRT: Pelvic radiotherapy dose is 50 Gy in 25 fractions (2.0 Gy per fraction) over 5 weeks. HDR brachytberapy dose is 7 Gy per fraction, total 4 fractions, each in a week over 4 weeks. Results: Ninety-eight patients were entered in the study. Three patients were excluded due to active non-malignant diseases. One patient had active tuberculosis, two patients had severe skin reactions and two patients withdrew following the first HDR application. The remaining Ninety patients were analyzed. Ninety patients completed the prescribed treatment and were evaluated. Eighty had complete response with relief of symptoms, negative Pap-smear and no clinical signs of persistence disease at 3 months. Ten patients had a positive Pap-smear with clinical signs of persistence disease. Patients were evaluated before statting treatment with EBRT and before starting treatment with HDR ICBT. Conclusion: It can be easily concluded that 4 fractions of HDR ICBT, 7 Gy each weekly and pelvic EBRT can effectively and safely control locally advanced carcinoma of the uterine cervix. So that EBRT and HDR ICBT is an acceptable treatment for locally advanced carcinoma of the uterine cervix. Careful attention to normal tissue doses such as the rectum, bladder, and small bowel is important in the treatment of locally advanced cervical cancer.https://www.banglajol.info/index.php/BSMMUJ/article/view/29143Beam radiotherapyBrachytherapyCarcinomaUterine cervix |
| spellingShingle | Md. Zillur Rahman Bhuiyan Atiar Rahman Sarwar Alam Sheikh Saiful Islam Shaheen Md. Ashadul lslam S. K. Golam Mostafa External beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervix Bangabandhu Sheikh Mujib Medical University Journal Beam radiotherapy Brachytherapy Carcinoma Uterine cervix |
| title | External beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervix |
| title_full | External beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervix |
| title_fullStr | External beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervix |
| title_full_unstemmed | External beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervix |
| title_short | External beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervix |
| title_sort | external beam radiotherapy and intracavitary brachytherapy is an acceptable treatment for locally advanced carcinoma of the uterine cervix |
| topic | Beam radiotherapy Brachytherapy Carcinoma Uterine cervix |
| url | https://www.banglajol.info/index.php/BSMMUJ/article/view/29143 |
| work_keys_str_mv | AT mdzillurrahmanbhuiyan externalbeamradiotherapyandintracavitarybrachytherapyisanacceptabletreatmentforlocallyadvancedcarcinomaoftheuterinecervix AT atiarrahman externalbeamradiotherapyandintracavitarybrachytherapyisanacceptabletreatmentforlocallyadvancedcarcinomaoftheuterinecervix AT sarwaralam externalbeamradiotherapyandintracavitarybrachytherapyisanacceptabletreatmentforlocallyadvancedcarcinomaoftheuterinecervix AT sheikhsaifulislamshaheen externalbeamradiotherapyandintracavitarybrachytherapyisanacceptabletreatmentforlocallyadvancedcarcinomaoftheuterinecervix AT mdashadullslam externalbeamradiotherapyandintracavitarybrachytherapyisanacceptabletreatmentforlocallyadvancedcarcinomaoftheuterinecervix AT skgolammostafa externalbeamradiotherapyandintracavitarybrachytherapyisanacceptabletreatmentforlocallyadvancedcarcinomaoftheuterinecervix |