Relationship of inflammatory and metabolic parameters in adolescents with PCOS: BMI matched case-control study
ABSTRACT Objective: Polycystic ovary syndrome (PCOS) begins in adolescence and has cardiovascular and metabolic components in later years. Cystatin C and high-sensitivity C-reactive protein (hs-CRP) levels and neutrophil-lymphocyte and platelet-lymphocyte ratios are associated with metabolic and in...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2022-06-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005007208&tlng=en |
| _version_ | 1818211582634622976 |
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| author | Aysun Tekeli Taşkömür Özlem Erten |
| author_facet | Aysun Tekeli Taşkömür Özlem Erten |
| author_sort | Aysun Tekeli Taşkömür |
| collection | DOAJ |
| description | ABSTRACT Objective: Polycystic ovary syndrome (PCOS) begins in adolescence and has cardiovascular and metabolic components in later years. Cystatin C and high-sensitivity C-reactive protein (hs-CRP) levels and neutrophil-lymphocyte and platelet-lymphocyte ratios are associated with metabolic and inflammatory events. Here, we evaluated inflammatory and metabolic parameters in normal and overweight adolescents with PCOS. Materials and methods: This prospective case-control study enrolled 90 adolescents with PCOS and 100 matched by age and BMI healthy adolescents classified as either normal weight (NW) and overweight (OW). Groups were compared based on inflammatory and metabolic parameters (serum cystatin C, hs-CRP, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lipids, fasting blood glucose-insulin (FBG-FI), HOMA-IR levels, waist circumference [WC], and waist-hip ratio [WHR]). The relationship between the parameters were compared and predictive abilities were evaluated. Results: Cystatin C, hs-CRP, NLR, triglyceride (TG), FBG-FI, HOMA-IR, WC, and WHR were significantly higher in those with PCOS. The NW PCOS group had significantly higher TG, cystatin C, hs-CRP, and NLR versus OW controls. The highest HOMA-IR values were observed in OW PCOS (p < .05). Cystatin C and hs-CRP sensitivity and specificity were significant (p < 0.05). Cystatin C and hs-CRP were positively correlated with other metabolic parameters. Conclusion: Independent of BMI, inflammatory and metabolic parameters are significantly higher in adolescents with PCOS compared to controls and even worse in those who are also OW. Therefore, adolescents with PCOS should be encouraged to maintain healthy lifestyles and weights to avoid metabolic risks. Hs-CRP and cystatin C could be promising markers to predictive of future metabolic risks. |
| first_indexed | 2024-12-12T05:34:48Z |
| format | Article |
| id | doaj.art-2b705e6d5fa74e1fb3a18d51cd164c15 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-12T05:34:48Z |
| publishDate | 2022-06-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-2b705e6d5fa74e1fb3a18d51cd164c152022-12-22T00:36:10ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922022-06-0110.20945/2359-3997000000497Relationship of inflammatory and metabolic parameters in adolescents with PCOS: BMI matched case-control studyAysun Tekeli Taşkömürhttps://orcid.org/0000-0001-7839-6963Özlem Ertenhttps://orcid.org/0000-0002-3178-8297ABSTRACT Objective: Polycystic ovary syndrome (PCOS) begins in adolescence and has cardiovascular and metabolic components in later years. Cystatin C and high-sensitivity C-reactive protein (hs-CRP) levels and neutrophil-lymphocyte and platelet-lymphocyte ratios are associated with metabolic and inflammatory events. Here, we evaluated inflammatory and metabolic parameters in normal and overweight adolescents with PCOS. Materials and methods: This prospective case-control study enrolled 90 adolescents with PCOS and 100 matched by age and BMI healthy adolescents classified as either normal weight (NW) and overweight (OW). Groups were compared based on inflammatory and metabolic parameters (serum cystatin C, hs-CRP, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lipids, fasting blood glucose-insulin (FBG-FI), HOMA-IR levels, waist circumference [WC], and waist-hip ratio [WHR]). The relationship between the parameters were compared and predictive abilities were evaluated. Results: Cystatin C, hs-CRP, NLR, triglyceride (TG), FBG-FI, HOMA-IR, WC, and WHR were significantly higher in those with PCOS. The NW PCOS group had significantly higher TG, cystatin C, hs-CRP, and NLR versus OW controls. The highest HOMA-IR values were observed in OW PCOS (p < .05). Cystatin C and hs-CRP sensitivity and specificity were significant (p < 0.05). Cystatin C and hs-CRP were positively correlated with other metabolic parameters. Conclusion: Independent of BMI, inflammatory and metabolic parameters are significantly higher in adolescents with PCOS compared to controls and even worse in those who are also OW. Therefore, adolescents with PCOS should be encouraged to maintain healthy lifestyles and weights to avoid metabolic risks. Hs-CRP and cystatin C could be promising markers to predictive of future metabolic risks.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005007208&tlng=enAdolescentpolycystic ovary syndromecystatin C, high-sensitivity C-reactive proteinneutrophil-lymphocyte ratioplatelet-lymphocyte ratio |
| spellingShingle | Aysun Tekeli Taşkömür Özlem Erten Relationship of inflammatory and metabolic parameters in adolescents with PCOS: BMI matched case-control study Archives of Endocrinology and Metabolism Adolescent polycystic ovary syndrome cystatin C, high-sensitivity C-reactive protein neutrophil-lymphocyte ratio platelet-lymphocyte ratio |
| title | Relationship of inflammatory and metabolic parameters in adolescents with PCOS: BMI matched case-control study |
| title_full | Relationship of inflammatory and metabolic parameters in adolescents with PCOS: BMI matched case-control study |
| title_fullStr | Relationship of inflammatory and metabolic parameters in adolescents with PCOS: BMI matched case-control study |
| title_full_unstemmed | Relationship of inflammatory and metabolic parameters in adolescents with PCOS: BMI matched case-control study |
| title_short | Relationship of inflammatory and metabolic parameters in adolescents with PCOS: BMI matched case-control study |
| title_sort | relationship of inflammatory and metabolic parameters in adolescents with pcos bmi matched case control study |
| topic | Adolescent polycystic ovary syndrome cystatin C, high-sensitivity C-reactive protein neutrophil-lymphocyte ratio platelet-lymphocyte ratio |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005007208&tlng=en |
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