Artificially cloaked viral nanovaccine for cancer immunotherapy
Cancer therapy using oncolytic virus has shown pre-clinical and clinical efficacy. Here, the authors report ExtraCRAd, an oncolytic virus cloaked with tumour cell membrane and report its therapeutic effects in vitro and in vivo in multiple mouse tumour models.
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13744-8 |
| _version_ | 1819194680223465472 |
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| author | Manlio Fusciello Flavia Fontana Siri Tähtinen Cristian Capasso Sara Feola Beatriz Martins Jacopo Chiaro Karita Peltonen Leena Ylösmäki Erkko Ylösmäki Firas Hamdan Otto K. Kari Joseph Ndika Harri Alenius Arto Urtti Jouni T. Hirvonen Hélder A. Santos Vincenzo Cerullo |
| author_facet | Manlio Fusciello Flavia Fontana Siri Tähtinen Cristian Capasso Sara Feola Beatriz Martins Jacopo Chiaro Karita Peltonen Leena Ylösmäki Erkko Ylösmäki Firas Hamdan Otto K. Kari Joseph Ndika Harri Alenius Arto Urtti Jouni T. Hirvonen Hélder A. Santos Vincenzo Cerullo |
| author_sort | Manlio Fusciello |
| collection | DOAJ |
| description | Cancer therapy using oncolytic virus has shown pre-clinical and clinical efficacy. Here, the authors report ExtraCRAd, an oncolytic virus cloaked with tumour cell membrane and report its therapeutic effects in vitro and in vivo in multiple mouse tumour models. |
| first_indexed | 2024-12-23T02:00:43Z |
| format | Article |
| id | doaj.art-2b72055f0b5e4f6496735a1c2b068f78 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:00:43Z |
| publishDate | 2019-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2b72055f0b5e4f6496735a1c2b068f782022-12-21T18:03:59ZengNature PortfolioNature Communications2041-17232019-12-0110111310.1038/s41467-019-13744-8Artificially cloaked viral nanovaccine for cancer immunotherapyManlio Fusciello0Flavia Fontana1Siri Tähtinen2Cristian Capasso3Sara Feola4Beatriz Martins5Jacopo Chiaro6Karita Peltonen7Leena Ylösmäki8Erkko Ylösmäki9Firas Hamdan10Otto K. Kari11Joseph Ndika12Harri Alenius13Arto Urtti14Jouni T. Hirvonen15Hélder A. Santos16Vincenzo Cerullo17Drug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiSystems Toxicology Group, Department of Bacteriology and Immunology, Medicum, University of HelsinkiSystems Toxicology Group, Department of Bacteriology and Immunology, Medicum, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of HelsinkiDrug Research Program, Division of Pharmaceutical Biosciences and Digital Precision Cancer Medicine Flagship (iCAN), Faculty of Pharmacy, University of HelsinkiCancer therapy using oncolytic virus has shown pre-clinical and clinical efficacy. Here, the authors report ExtraCRAd, an oncolytic virus cloaked with tumour cell membrane and report its therapeutic effects in vitro and in vivo in multiple mouse tumour models.https://doi.org/10.1038/s41467-019-13744-8 |
| spellingShingle | Manlio Fusciello Flavia Fontana Siri Tähtinen Cristian Capasso Sara Feola Beatriz Martins Jacopo Chiaro Karita Peltonen Leena Ylösmäki Erkko Ylösmäki Firas Hamdan Otto K. Kari Joseph Ndika Harri Alenius Arto Urtti Jouni T. Hirvonen Hélder A. Santos Vincenzo Cerullo Artificially cloaked viral nanovaccine for cancer immunotherapy Nature Communications |
| title | Artificially cloaked viral nanovaccine for cancer immunotherapy |
| title_full | Artificially cloaked viral nanovaccine for cancer immunotherapy |
| title_fullStr | Artificially cloaked viral nanovaccine for cancer immunotherapy |
| title_full_unstemmed | Artificially cloaked viral nanovaccine for cancer immunotherapy |
| title_short | Artificially cloaked viral nanovaccine for cancer immunotherapy |
| title_sort | artificially cloaked viral nanovaccine for cancer immunotherapy |
| url | https://doi.org/10.1038/s41467-019-13744-8 |
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