The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson’s Disease

The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson’s Disease

Parkinson’s disease (PD) is characterized by selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc). α-synuclein (α-syn) is known to regulate mitochondrial function and both PINK1 and Parkin have been shown to eliminate damaged mitochondria in PD. Mecha...

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Bibliographic Details
Main Authors: Mahesh Ramalingam, Yu-Jin Huh, Yun-Il Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
rotenone
SH-SY5Y
α-synuclein
mitofusin
stereotaxic
mTOR
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01028/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01028/full

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