Osteosarcoma in Adolescents and Young Adults
The epidemiology of osteosarcoma in adolescents and young adults (AYA) remains unclear. We aimed to assess and compare the clinical features of osteosarcoma between AYA and other age groups. We retrieved osteosarcoma cases diagnosed between 1999 and 2017 from the Korea Central Cancer Registry. We co...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/10/2684 |
| _version_ | 1797514984069005312 |
|---|---|
| author | Jun Ah Lee Jiwon Lim Hye Young Jin Meerim Park Hyeon Jin Park Jong Woong Park June Hyuk Kim Hyun Guy Kang Young-Joo Won |
| author_facet | Jun Ah Lee Jiwon Lim Hye Young Jin Meerim Park Hyeon Jin Park Jong Woong Park June Hyuk Kim Hyun Guy Kang Young-Joo Won |
| author_sort | Jun Ah Lee |
| collection | DOAJ |
| description | The epidemiology of osteosarcoma in adolescents and young adults (AYA) remains unclear. We aimed to assess and compare the clinical features of osteosarcoma between AYA and other age groups. We retrieved osteosarcoma cases diagnosed between 1999 and 2017 from the Korea Central Cancer Registry. We compared survival trends and clinical characteristics between AYA and other age groups. AYA comprised 43.3% (1309/3022) of the osteosarcoma cases. Compared to other age groups, the male-to-female ratio was highest in AYA (1.61:1). The proportion of tumors located in an extremity was 80.3% in AYA, which was lower than in young children (92.5%) or pubertal children (93.8%) but higher than in adults (55.7%) or the elderly (47.5%). As for treatments, 71.2% of AYA received local treatment and systemic chemotherapy, and 28.8% received only local treatment (surgery: 261, radiotherapy: 9, surgery and radiotherapy: 5). The 5-year overall survival (OS) was lower in AYA (68%) than in young children (78%) or pubertal children (73%) but higher than in adults (47%) or the elderly (25%). When AYA were divided into five subgroups by age, patients aged 15–19 years constituted the largest proportion (45.4%, <i>n</i> = 594). Additionally, the proportion of patients with a non-extremity tumor increased in an age-dependent manner, from 10.3% in AYA aged 15–19 years to 35.3% in AYA aged 35–39 years. OS did not significantly differ among the different age subgroups of AYA. The clinical characteristics and OS of the AYA were more similar to those of children than to those of adults. There is a need for cooperation between pediatric and adult oncologists for effective osteosarcoma treatment in AYA. |
| first_indexed | 2024-03-10T06:39:15Z |
| format | Article |
| id | doaj.art-2b72eeb6d06b443f8ad189b66f855765 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:15Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2b72eeb6d06b443f8ad189b66f8557652023-11-22T17:47:30ZengMDPI AGCells2073-44092021-10-011010268410.3390/cells10102684Osteosarcoma in Adolescents and Young AdultsJun Ah Lee0Jiwon Lim1Hye Young Jin2Meerim Park3Hyeon Jin Park4Jong Woong Park5June Hyuk Kim6Hyun Guy Kang7Young-Joo Won8Center for Pediatric Cancer, Department of Pediatrics, Goyang 10408, KoreaDivision of Cancer Registration and Surveillance, Goyang 10408, KoreaCenter for Pediatric Cancer, Department of Pediatrics, Goyang 10408, KoreaCenter for Pediatric Cancer, Department of Pediatrics, Goyang 10408, KoreaCenter for Pediatric Cancer, Department of Pediatrics, Goyang 10408, KoreaOrthopedic Oncology Clinic, Center for Rare Cancer, National Cancer Center, Goyang 10408, KoreaOrthopedic Oncology Clinic, Center for Rare Cancer, National Cancer Center, Goyang 10408, KoreaOrthopedic Oncology Clinic, Center for Rare Cancer, National Cancer Center, Goyang 10408, KoreaDivision of Cancer Registration and Surveillance, Goyang 10408, KoreaThe epidemiology of osteosarcoma in adolescents and young adults (AYA) remains unclear. We aimed to assess and compare the clinical features of osteosarcoma between AYA and other age groups. We retrieved osteosarcoma cases diagnosed between 1999 and 2017 from the Korea Central Cancer Registry. We compared survival trends and clinical characteristics between AYA and other age groups. AYA comprised 43.3% (1309/3022) of the osteosarcoma cases. Compared to other age groups, the male-to-female ratio was highest in AYA (1.61:1). The proportion of tumors located in an extremity was 80.3% in AYA, which was lower than in young children (92.5%) or pubertal children (93.8%) but higher than in adults (55.7%) or the elderly (47.5%). As for treatments, 71.2% of AYA received local treatment and systemic chemotherapy, and 28.8% received only local treatment (surgery: 261, radiotherapy: 9, surgery and radiotherapy: 5). The 5-year overall survival (OS) was lower in AYA (68%) than in young children (78%) or pubertal children (73%) but higher than in adults (47%) or the elderly (25%). When AYA were divided into five subgroups by age, patients aged 15–19 years constituted the largest proportion (45.4%, <i>n</i> = 594). Additionally, the proportion of patients with a non-extremity tumor increased in an age-dependent manner, from 10.3% in AYA aged 15–19 years to 35.3% in AYA aged 35–39 years. OS did not significantly differ among the different age subgroups of AYA. The clinical characteristics and OS of the AYA were more similar to those of children than to those of adults. There is a need for cooperation between pediatric and adult oncologists for effective osteosarcoma treatment in AYA.https://www.mdpi.com/2073-4409/10/10/2684osteosarcomaadolescents and young adults (AYA)Korea |
| spellingShingle | Jun Ah Lee Jiwon Lim Hye Young Jin Meerim Park Hyeon Jin Park Jong Woong Park June Hyuk Kim Hyun Guy Kang Young-Joo Won Osteosarcoma in Adolescents and Young Adults Cells osteosarcoma adolescents and young adults (AYA) Korea |
| title | Osteosarcoma in Adolescents and Young Adults |
| title_full | Osteosarcoma in Adolescents and Young Adults |
| title_fullStr | Osteosarcoma in Adolescents and Young Adults |
| title_full_unstemmed | Osteosarcoma in Adolescents and Young Adults |
| title_short | Osteosarcoma in Adolescents and Young Adults |
| title_sort | osteosarcoma in adolescents and young adults |
| topic | osteosarcoma adolescents and young adults (AYA) Korea |
| url | https://www.mdpi.com/2073-4409/10/10/2684 |
| work_keys_str_mv | AT junahlee osteosarcomainadolescentsandyoungadults AT jiwonlim osteosarcomainadolescentsandyoungadults AT hyeyoungjin osteosarcomainadolescentsandyoungadults AT meerimpark osteosarcomainadolescentsandyoungadults AT hyeonjinpark osteosarcomainadolescentsandyoungadults AT jongwoongpark osteosarcomainadolescentsandyoungadults AT junehyukkim osteosarcomainadolescentsandyoungadults AT hyunguykang osteosarcomainadolescentsandyoungadults AT youngjoowon osteosarcomainadolescentsandyoungadults |