Morphological spectrum of peripheral nerve sheath tumors: A series of 126 cases
By convention, soft tissue tumors include the peripheral nerve sheath tumor (PNST) although they arise from neuroectoderm. PNSTs display a wide spectrum of morphology and biological behavior. Malignant transformation in benign tumors, especially neurofibroma, is an acknowledged phenomenon.This artic...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=1;spage=29;epage=33;aulast=Gabhane |
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| author | Gabhane Sushma Kotwal Mrunamayi Bobhate Sudhakar |
| author_facet | Gabhane Sushma Kotwal Mrunamayi Bobhate Sudhakar |
| author_sort | Gabhane Sushma |
| collection | DOAJ |
| description | By convention, soft tissue tumors include the peripheral nerve sheath tumor (PNST) although they arise from neuroectoderm. PNSTs display a wide spectrum of morphology and biological behavior. Malignant transformation in benign tumors, especially neurofibroma, is an acknowledged phenomenon.This article describes clinico-pathological features of 126 PNSTs with their morphological variants and those associated with neurofibromatosis 1 (NF1) encountered in a single center over a 6-year period. Benign PNSTs were more common [118 (93.65%)] when compared with their malignant counterparts [8 (6.34%)]. Histological variants including plexiform schwannomas and diffuse, plexiform and pigmented forms of neurofibromas, though rare, were observed. Eleven (8.73%) patients with NF1 showed a strong association with plexiform neurofibroma. A malignant transformation in pre-existing neurofibroma was seen in 1 patient with NF1. This series highlights the clinico-pathological spectrum of PNSTs, their morphological variants and the incidence of associated NF1. The importance of detecting plexiform variants lies in their vastly different prognostic implications particularly when occurring in the setting of NF1 |
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| format | Article |
| id | doaj.art-2b73da10a03f4aa28b9bcf51073be84f |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-20T03:00:27Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-2b73da10a03f4aa28b9bcf51073be84f2022-12-21T19:55:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292009-01-015212933Morphological spectrum of peripheral nerve sheath tumors: A series of 126 casesGabhane SushmaKotwal MrunamayiBobhate SudhakarBy convention, soft tissue tumors include the peripheral nerve sheath tumor (PNST) although they arise from neuroectoderm. PNSTs display a wide spectrum of morphology and biological behavior. Malignant transformation in benign tumors, especially neurofibroma, is an acknowledged phenomenon.This article describes clinico-pathological features of 126 PNSTs with their morphological variants and those associated with neurofibromatosis 1 (NF1) encountered in a single center over a 6-year period. Benign PNSTs were more common [118 (93.65%)] when compared with their malignant counterparts [8 (6.34%)]. Histological variants including plexiform schwannomas and diffuse, plexiform and pigmented forms of neurofibromas, though rare, were observed. Eleven (8.73%) patients with NF1 showed a strong association with plexiform neurofibroma. A malignant transformation in pre-existing neurofibroma was seen in 1 patient with NF1. This series highlights the clinico-pathological spectrum of PNSTs, their morphological variants and the incidence of associated NF1. The importance of detecting plexiform variants lies in their vastly different prognostic implications particularly when occurring in the setting of NF1http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=1;spage=29;epage=33;aulast=GabhaneMPNSTneurofibromaneurofibromatosis 1peripheral nerve sheath tumorschwannoma |
| spellingShingle | Gabhane Sushma Kotwal Mrunamayi Bobhate Sudhakar Morphological spectrum of peripheral nerve sheath tumors: A series of 126 cases Indian Journal of Pathology and Microbiology MPNST neurofibroma neurofibromatosis 1 peripheral nerve sheath tumor schwannoma |
| title | Morphological spectrum of peripheral nerve sheath tumors: A series of 126 cases |
| title_full | Morphological spectrum of peripheral nerve sheath tumors: A series of 126 cases |
| title_fullStr | Morphological spectrum of peripheral nerve sheath tumors: A series of 126 cases |
| title_full_unstemmed | Morphological spectrum of peripheral nerve sheath tumors: A series of 126 cases |
| title_short | Morphological spectrum of peripheral nerve sheath tumors: A series of 126 cases |
| title_sort | morphological spectrum of peripheral nerve sheath tumors a series of 126 cases |
| topic | MPNST neurofibroma neurofibromatosis 1 peripheral nerve sheath tumor schwannoma |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=1;spage=29;epage=33;aulast=Gabhane |
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