Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease
Uterine fibroids have been described as an associate to acute venous thromboembolism (VTE), with case reports showing an association between large uterine fibroids, acute deep venous thrombosis (DVT), and acute pulmonary embolism (PE). However, there is little known about the association or causatio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-12-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894018803873 |
| _version_ | 1818247352487510016 |
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| author | Anne-Sophie Lacharite-Roberge Farhan Raza Riyaz Bashir Chandra A. Dass G. William Moser William R. Auger Yoshiya Toyoda Paul R. Forfia Anjali Vaidya |
| author_facet | Anne-Sophie Lacharite-Roberge Farhan Raza Riyaz Bashir Chandra A. Dass G. William Moser William R. Auger Yoshiya Toyoda Paul R. Forfia Anjali Vaidya |
| author_sort | Anne-Sophie Lacharite-Roberge |
| collection | DOAJ |
| description | Uterine fibroids have been described as an associate to acute venous thromboembolism (VTE), with case reports showing an association between large uterine fibroids, acute deep venous thrombosis (DVT), and acute pulmonary embolism (PE). However, there is little known about the association or causation between uterine fibroids, chronic thromboembolic disease (CTED), and chronic thromboembolic pulmonary hypertension (CTEPH). We report on six women with uterine fibroids and CTEPH, as well as one woman with CTED, all of whom presented with exertional dyspnea, lower extremity swelling, and in the cases of CTEPH, clinical, echocardiographic, and hemodynamic evidence of pulmonary hypertension and right heart failure. Compression of the pelvic veins by fibroids was directly observed with invasive venography or contrast-enhanced computed tomography in five cases. All seven women underwent pulmonary thromboendarterectomy (PTE) followed by marked improvement in functional, clinical, and hemodynamic status. |
| first_indexed | 2024-12-12T15:03:20Z |
| format | Article |
| id | doaj.art-2b7410ac07d6453ca4a806e1df761b5b |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-12-12T15:03:20Z |
| publishDate | 2018-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-2b7410ac07d6453ca4a806e1df761b5b2022-12-22T00:20:46ZengWileyPulmonary Circulation2045-89402018-12-01910.1177/2045894018803873Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic diseaseAnne-Sophie Lacharite-Roberge0Farhan Raza1Riyaz Bashir2Chandra A. Dass3G. William Moser4William R. Auger5Yoshiya Toyoda6Paul R. Forfia7Anjali Vaidya8Department of Medicine, Temple University Hospital, Philadelphia, PA, USAHeart and Vascular Institute, Temple University Hospital, Philadelphia, PA, USAHeart and Vascular Institute, Temple University Hospital, Philadelphia, PA, USADepartment of Radiology, Temple University Hospital, Philadelphia, PA, USADepartment of Cardiovascular Surgery, Temple University Hospital, Philadelphia, PA, USAHeart and Vascular Institute, Temple University Hospital, Philadelphia, PA, USADepartment of Cardiovascular Surgery, Temple University Hospital, Philadelphia, PA, USAHeart and Vascular Institute, Temple University Hospital, Philadelphia, PA, USAHeart and Vascular Institute, Temple University Hospital, Philadelphia, PA, USAUterine fibroids have been described as an associate to acute venous thromboembolism (VTE), with case reports showing an association between large uterine fibroids, acute deep venous thrombosis (DVT), and acute pulmonary embolism (PE). However, there is little known about the association or causation between uterine fibroids, chronic thromboembolic disease (CTED), and chronic thromboembolic pulmonary hypertension (CTEPH). We report on six women with uterine fibroids and CTEPH, as well as one woman with CTED, all of whom presented with exertional dyspnea, lower extremity swelling, and in the cases of CTEPH, clinical, echocardiographic, and hemodynamic evidence of pulmonary hypertension and right heart failure. Compression of the pelvic veins by fibroids was directly observed with invasive venography or contrast-enhanced computed tomography in five cases. All seven women underwent pulmonary thromboendarterectomy (PTE) followed by marked improvement in functional, clinical, and hemodynamic status.https://doi.org/10.1177/2045894018803873 |
| spellingShingle | Anne-Sophie Lacharite-Roberge Farhan Raza Riyaz Bashir Chandra A. Dass G. William Moser William R. Auger Yoshiya Toyoda Paul R. Forfia Anjali Vaidya Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease Pulmonary Circulation |
| title | Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease |
| title_full | Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease |
| title_fullStr | Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease |
| title_full_unstemmed | Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease |
| title_short | Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease |
| title_sort | case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease |
| url | https://doi.org/10.1177/2045894018803873 |
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