<i>Bifidobacterium longum</i> Subspecies <i>infantis</i> (<i>B. infantis</i>) in Pediatric Nutrition: Current State of Knowledge
Since originally isolated in 1899, the genus <i>Bifidobacterium</i> has been demonstrated to predominate in the gut microbiota of breastfed infants and to benefit the host by accelerating maturation of the immune response, balancing the immune system to suppress inflammation, improving i...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1581 |
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| author | Maciej Chichlowski Neil Shah Jennifer L. Wampler Steven S. Wu Jon A. Vanderhoof |
| author_facet | Maciej Chichlowski Neil Shah Jennifer L. Wampler Steven S. Wu Jon A. Vanderhoof |
| author_sort | Maciej Chichlowski |
| collection | DOAJ |
| description | Since originally isolated in 1899, the genus <i>Bifidobacterium</i> has been demonstrated to predominate in the gut microbiota of breastfed infants and to benefit the host by accelerating maturation of the immune response, balancing the immune system to suppress inflammation, improving intestinal barrier function, and increasing acetate production. In particular, <i>Bifidobacterium longum</i> subspecies <i>infantis</i> (<i>B. infantis</i>) is well adapted to the infant gut and has co-evolved with the mother-infant dyad and gut microbiome, in part due to its ability to consume complex carbohydrates found in human milk. <i>B. infantis</i> and its human host have a symbiotic relationship that protects the preterm or term neonate and nourishes a healthy gut microbiota prior to weaning. To provide benefits associated with <i>B. infantis</i> to all infants, a number of commercialized strains have been developed over the past decades. As new ingredients become available, safety and suitability must be assessed in preclinical and clinical studies. Consideration of the full clinical evidence for <i>B. infantis</i> use in pediatric nutrition is critical to better understand its potential impacts on infant health and development. Herein we summarize the recent clinical studies utilizing select strains of commercialized <i>B. infantis</i>. |
| first_indexed | 2024-03-10T19:32:28Z |
| format | Article |
| id | doaj.art-2b74b05ee2e9416fba5b9b4016a644f5 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:32:28Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-2b74b05ee2e9416fba5b9b4016a644f52023-11-20T02:00:33ZengMDPI AGNutrients2072-66432020-05-01126158110.3390/nu12061581<i>Bifidobacterium longum</i> Subspecies <i>infantis</i> (<i>B. infantis</i>) in Pediatric Nutrition: Current State of KnowledgeMaciej Chichlowski0Neil Shah1Jennifer L. Wampler2Steven S. Wu3Jon A. Vanderhoof4Nutrition Science, Department of Medical Affairs, Mead Johnson Nutrition, Evansville, IN 47721, USANutrition Science, Department of Medical Affairs, Mead Johnson Nutrition, Evansville, IN 47721, USAClinical Research, Department of Medical Affairs, Mead Johnson Nutrition, Evansville, IN 47721, USAClinical Research, Department of Medical Affairs, Mead Johnson Nutrition, Evansville, IN 47721, USABoston Children’s Hospital, Gastroenterology, Boston, MA 02115, USASince originally isolated in 1899, the genus <i>Bifidobacterium</i> has been demonstrated to predominate in the gut microbiota of breastfed infants and to benefit the host by accelerating maturation of the immune response, balancing the immune system to suppress inflammation, improving intestinal barrier function, and increasing acetate production. In particular, <i>Bifidobacterium longum</i> subspecies <i>infantis</i> (<i>B. infantis</i>) is well adapted to the infant gut and has co-evolved with the mother-infant dyad and gut microbiome, in part due to its ability to consume complex carbohydrates found in human milk. <i>B. infantis</i> and its human host have a symbiotic relationship that protects the preterm or term neonate and nourishes a healthy gut microbiota prior to weaning. To provide benefits associated with <i>B. infantis</i> to all infants, a number of commercialized strains have been developed over the past decades. As new ingredients become available, safety and suitability must be assessed in preclinical and clinical studies. Consideration of the full clinical evidence for <i>B. infantis</i> use in pediatric nutrition is critical to better understand its potential impacts on infant health and development. Herein we summarize the recent clinical studies utilizing select strains of commercialized <i>B. infantis</i>.https://www.mdpi.com/2072-6643/12/6/1581<i>Bifidobacterium longum</i> subspecies <i>infantis</i><i>B. infantis</i>probioticspediatric nutritionhuman milk oligosaccharidesinflammation |
| spellingShingle | Maciej Chichlowski Neil Shah Jennifer L. Wampler Steven S. Wu Jon A. Vanderhoof <i>Bifidobacterium longum</i> Subspecies <i>infantis</i> (<i>B. infantis</i>) in Pediatric Nutrition: Current State of Knowledge Nutrients <i>Bifidobacterium longum</i> subspecies <i>infantis</i> <i>B. infantis</i> probiotics pediatric nutrition human milk oligosaccharides inflammation |
| title | <i>Bifidobacterium longum</i> Subspecies <i>infantis</i> (<i>B. infantis</i>) in Pediatric Nutrition: Current State of Knowledge |
| title_full | <i>Bifidobacterium longum</i> Subspecies <i>infantis</i> (<i>B. infantis</i>) in Pediatric Nutrition: Current State of Knowledge |
| title_fullStr | <i>Bifidobacterium longum</i> Subspecies <i>infantis</i> (<i>B. infantis</i>) in Pediatric Nutrition: Current State of Knowledge |
| title_full_unstemmed | <i>Bifidobacterium longum</i> Subspecies <i>infantis</i> (<i>B. infantis</i>) in Pediatric Nutrition: Current State of Knowledge |
| title_short | <i>Bifidobacterium longum</i> Subspecies <i>infantis</i> (<i>B. infantis</i>) in Pediatric Nutrition: Current State of Knowledge |
| title_sort | i bifidobacterium longum i subspecies i infantis i i b infantis i in pediatric nutrition current state of knowledge |
| topic | <i>Bifidobacterium longum</i> subspecies <i>infantis</i> <i>B. infantis</i> probiotics pediatric nutrition human milk oligosaccharides inflammation |
| url | https://www.mdpi.com/2072-6643/12/6/1581 |
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