Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 1–2% of the population aged 65 and over. Additionally, non-motor symptoms such as pain and gastrointestinal dysregulation are also common in PD. These impairments might stem from a dysregulation within the gut-b...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.759679/full |
| _version_ | 1818996406898130944 |
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| author | Katiane Roversi Katiane Roversi Katiane Roversi Katiane Roversi Natalia Callai-Silva Natalia Callai-Silva Natalia Callai-Silva Karine Roversi May Griffith May Griffith Christos Boutopoulos Christos Boutopoulos Rui Daniel Prediger Sébastien Talbot |
| author_facet | Katiane Roversi Katiane Roversi Katiane Roversi Katiane Roversi Natalia Callai-Silva Natalia Callai-Silva Natalia Callai-Silva Karine Roversi May Griffith May Griffith Christos Boutopoulos Christos Boutopoulos Rui Daniel Prediger Sébastien Talbot |
| author_sort | Katiane Roversi |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 1–2% of the population aged 65 and over. Additionally, non-motor symptoms such as pain and gastrointestinal dysregulation are also common in PD. These impairments might stem from a dysregulation within the gut-brain axis that alters immunity and the inflammatory state and subsequently drives neurodegeneration. There is increasing evidence linking gut dysbiosis to the severity of PD’s motor symptoms as well as to somatosensory hypersensitivities. Altogether, these interdependent features highlight the urgency of reviewing the links between the onset of PD’s non-motor symptoms and gut immunity and whether such interplays drive the progression of PD. This review will shed light on maladaptive neuro-immune crosstalk in the context of gut dysbiosis and will posit that such deleterious interplays lead to PD-induced pain hypersensitivity. |
| first_indexed | 2024-12-20T21:29:14Z |
| format | Article |
| id | doaj.art-2b75063e3eb14437a175729816bf73c6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T21:29:14Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2b75063e3eb14437a175729816bf73c62022-12-21T19:26:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-11-011210.3389/fimmu.2021.759679759679Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced PainKatiane Roversi0Katiane Roversi1Katiane Roversi2Katiane Roversi3Natalia Callai-Silva4Natalia Callai-Silva5Natalia Callai-Silva6Karine Roversi7May Griffith8May Griffith9Christos Boutopoulos10Christos Boutopoulos11Rui Daniel Prediger12Sébastien Talbot13Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, QC, CanadaCentre de Recherche Hôpital Maisonneuve-Rosemont, Montréal, QC, CanadaDépartement d’Ophtalmologie, Université de Montréal, Montréal, QC, CanadaDepartamento de Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, BrazilDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, QC, CanadaCentre de Recherche Hôpital Maisonneuve-Rosemont, Montréal, QC, CanadaDépartement d’Ophtalmologie, Université de Montréal, Montréal, QC, CanadaDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, QC, CanadaCentre de Recherche Hôpital Maisonneuve-Rosemont, Montréal, QC, CanadaDépartement d’Ophtalmologie, Université de Montréal, Montréal, QC, CanadaCentre de Recherche Hôpital Maisonneuve-Rosemont, Montréal, QC, CanadaDépartement d’Ophtalmologie, Université de Montréal, Montréal, QC, CanadaDepartamento de Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, BrazilDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, QC, CanadaParkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 1–2% of the population aged 65 and over. Additionally, non-motor symptoms such as pain and gastrointestinal dysregulation are also common in PD. These impairments might stem from a dysregulation within the gut-brain axis that alters immunity and the inflammatory state and subsequently drives neurodegeneration. There is increasing evidence linking gut dysbiosis to the severity of PD’s motor symptoms as well as to somatosensory hypersensitivities. Altogether, these interdependent features highlight the urgency of reviewing the links between the onset of PD’s non-motor symptoms and gut immunity and whether such interplays drive the progression of PD. This review will shed light on maladaptive neuro-immune crosstalk in the context of gut dysbiosis and will posit that such deleterious interplays lead to PD-induced pain hypersensitivity.https://www.frontiersin.org/articles/10.3389/fimmu.2021.759679/fullParkinson’s diseasepainnociceptor neuronsneuro-immunitymicrobiotadysbiosis |
| spellingShingle | Katiane Roversi Katiane Roversi Katiane Roversi Katiane Roversi Natalia Callai-Silva Natalia Callai-Silva Natalia Callai-Silva Karine Roversi May Griffith May Griffith Christos Boutopoulos Christos Boutopoulos Rui Daniel Prediger Sébastien Talbot Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain Frontiers in Immunology Parkinson’s disease pain nociceptor neurons neuro-immunity microbiota dysbiosis |
| title | Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain |
| title_full | Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain |
| title_fullStr | Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain |
| title_full_unstemmed | Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain |
| title_short | Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain |
| title_sort | neuro immunity and gut dysbiosis drive parkinson s disease induced pain |
| topic | Parkinson’s disease pain nociceptor neurons neuro-immunity microbiota dysbiosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.759679/full |
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