An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis
Abstract. Background:. Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-06-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002228 |
| _version_ | 1811204237461291008 |
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| author | Yanhua Huang Zuoteng Wang Bing Zhao Yahui Ma Yanan Ou Hao Hu Xiaohe Hou Jintai Yu Lan Tan Yanjie Yin Xiuyuan Hao |
| author_facet | Yanhua Huang Zuoteng Wang Bing Zhao Yahui Ma Yanan Ou Hao Hu Xiaohe Hou Jintai Yu Lan Tan Yanjie Yin Xiuyuan Hao |
| author_sort | Yanhua Huang |
| collection | DOAJ |
| description | Abstract. Background:. Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with ICAS in a Chinese Han population.
Methods:. A total of 2134 participants (518 with ICAS, 1616 without ICAS) were enrolled in this study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of several main intracranial arteries. Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS. Additional subgroup analyses were performed according to age (<60 vs. ≥60 years) and acute ischemic stroke.
Results:. Multivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants (P < 0.001). Compared with the lowest quartile, the fourth PLR quartile was significantly associated with ICAS (OR 1.705, 95% confidence interval 1.278–2.275, P < 0.001). In the subgroups stratified by age, an association between the PLR and ICAS was found in the late-life group (P < 0.001), but not in the mid-life group (P = 0.650). In the subgroups stratified by acute ischemic stroke, the relationship between an elevated PLR and a higher risk of ICAS remained unchanged (stroke group, P < 0.001; non-stroke group, P = 0.027).
Conclusions:. An elevated PLR was associated with a higher risk of ICAS in a Chinese Han population. The PLR might serve as a potential biomarker for ICAS in the elderly population. |
| first_indexed | 2024-04-12T03:09:14Z |
| format | Article |
| id | doaj.art-2b7583bff43147dbb9152c9d562beb08 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-04-12T03:09:14Z |
| publishDate | 2022-06-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-2b7583bff43147dbb9152c9d562beb082022-12-22T03:50:25ZengWolters KluwerChinese Medical Journal0366-69992542-56412022-06-01135121425143110.1097/CM9.0000000000002228202206200-00006An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosisYanhua HuangZuoteng WangBing ZhaoYahui MaYanan OuHao HuXiaohe HouJintai YuLan TanYanjie YinXiuyuan HaoAbstract. Background:. Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with ICAS in a Chinese Han population. Methods:. A total of 2134 participants (518 with ICAS, 1616 without ICAS) were enrolled in this study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of several main intracranial arteries. Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS. Additional subgroup analyses were performed according to age (<60 vs. ≥60 years) and acute ischemic stroke. Results:. Multivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants (P < 0.001). Compared with the lowest quartile, the fourth PLR quartile was significantly associated with ICAS (OR 1.705, 95% confidence interval 1.278–2.275, P < 0.001). In the subgroups stratified by age, an association between the PLR and ICAS was found in the late-life group (P < 0.001), but not in the mid-life group (P = 0.650). In the subgroups stratified by acute ischemic stroke, the relationship between an elevated PLR and a higher risk of ICAS remained unchanged (stroke group, P < 0.001; non-stroke group, P = 0.027). Conclusions:. An elevated PLR was associated with a higher risk of ICAS in a Chinese Han population. The PLR might serve as a potential biomarker for ICAS in the elderly population.http://journals.lww.com/10.1097/CM9.0000000000002228 |
| spellingShingle | Yanhua Huang Zuoteng Wang Bing Zhao Yahui Ma Yanan Ou Hao Hu Xiaohe Hou Jintai Yu Lan Tan Yanjie Yin Xiuyuan Hao An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis Chinese Medical Journal |
| title | An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis |
| title_full | An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis |
| title_fullStr | An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis |
| title_full_unstemmed | An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis |
| title_short | An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis |
| title_sort | elevated platelet to lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis |
| url | http://journals.lww.com/10.1097/CM9.0000000000002228 |
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