Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06/HIF1α-SUMO/NCOA4 axis

Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06/HIF1α-SUMO/NCOA4 axis

Defects of human trophoblast cells may induce miscarriage (abnormal early embryo loss), which is generally regulated by lncRNAs. Ferroptosis is a newly identified iron-dependent programmed cell death. Hypoxia is an important and unavoidable feature in mammalian cells. However, whether hypoxia might...

Full description

Bibliographic Details
Main Authors: Peng Tian, Zhongyan Xu, Jiarong Guo, Jingsong Zhao, Weina Chen, Wenxin Huang, Manli Wang, Chenyang Mi, Ying Zhang, Yang Yang, Huidong Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
LncRNA or lnc-HZ06
Trophoblast cell ferroptosis
Hypoxia
Recurrent miscarriage
SUMOylated HIF1α and NCOA4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000491

Similar Items

Similar Items