Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics
The consumption of mushrooms has become increasingly popular, partly due to their nutritional and medicinal properties. This has increased the risk of confusion during picking, and thus of intoxication. In France, about 1300 cases of intoxication are observed each year, with deaths being mostly attr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/6/417 |
| _version_ | 1797530445223559168 |
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| author | Brendan Le Daré Pierre-Jean Ferron Thomas Gicquel |
| author_facet | Brendan Le Daré Pierre-Jean Ferron Thomas Gicquel |
| author_sort | Brendan Le Daré |
| collection | DOAJ |
| description | The consumption of mushrooms has become increasingly popular, partly due to their nutritional and medicinal properties. This has increased the risk of confusion during picking, and thus of intoxication. In France, about 1300 cases of intoxication are observed each year, with deaths being mostly attributed to <i>Amanita phalloides</i> poisoning. Among amatoxins, α- and β-amanitins are the most widely studied toxins. Hepatotoxicity is the hallmark of these compounds, leading to hepatocellular failure within three days of ingestion. The toxic mechanisms of action mainly include RNA polymerase II inhibition and oxidative stress generation, leading to hepatic cell apoptosis or necrosis depending on the doses ingested. Currently, there is no international consensus concerning <i>Amanita phalloides</i> poisoning management. However, antidotes with antioxidant properties remain the most effective therapeutics to date suggesting the predominant role of oxidative stress in the pathophysiology. The partially elucidated mechanisms of action may reveal a suitable target for the development of an antidote. The aim of this review is to present an overview of the knowledge on amanitins, including the latest advances that could allow the proposal of new innovative and effective therapeutics. |
| first_indexed | 2024-03-10T10:29:04Z |
| format | Article |
| id | doaj.art-2b7733cb51da43a0b58f69e0a3782256 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T10:29:04Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-2b7733cb51da43a0b58f69e0a37822562023-11-21T23:44:44ZengMDPI AGToxins2072-66512021-06-0113641710.3390/toxins13060417Toxic Effects of Amanitins: Repurposing Toxicities toward New TherapeuticsBrendan Le Daré0Pierre-Jean Ferron1Thomas Gicquel2Univ Rennes, INSERM, INRAE, CHU Rennes, Institut NuMeCan (Nutrition, Métabolismes et Cancer), Previtox Network, F-35000 Rennes, FranceUniv Rennes, INSERM, INRAE, CHU Rennes, Institut NuMeCan (Nutrition, Métabolismes et Cancer), Previtox Network, F-35000 Rennes, FranceUniv Rennes, INSERM, INRAE, CHU Rennes, Institut NuMeCan (Nutrition, Métabolismes et Cancer), Previtox Network, F-35000 Rennes, FranceThe consumption of mushrooms has become increasingly popular, partly due to their nutritional and medicinal properties. This has increased the risk of confusion during picking, and thus of intoxication. In France, about 1300 cases of intoxication are observed each year, with deaths being mostly attributed to <i>Amanita phalloides</i> poisoning. Among amatoxins, α- and β-amanitins are the most widely studied toxins. Hepatotoxicity is the hallmark of these compounds, leading to hepatocellular failure within three days of ingestion. The toxic mechanisms of action mainly include RNA polymerase II inhibition and oxidative stress generation, leading to hepatic cell apoptosis or necrosis depending on the doses ingested. Currently, there is no international consensus concerning <i>Amanita phalloides</i> poisoning management. However, antidotes with antioxidant properties remain the most effective therapeutics to date suggesting the predominant role of oxidative stress in the pathophysiology. The partially elucidated mechanisms of action may reveal a suitable target for the development of an antidote. The aim of this review is to present an overview of the knowledge on amanitins, including the latest advances that could allow the proposal of new innovative and effective therapeutics.https://www.mdpi.com/2072-6651/13/6/417amanitinhepatotoxicity<i>Amanita phalloïdes</i>antidoteamanitin-conjugated antibody |
| spellingShingle | Brendan Le Daré Pierre-Jean Ferron Thomas Gicquel Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics Toxins amanitin hepatotoxicity <i>Amanita phalloïdes</i> antidote amanitin-conjugated antibody |
| title | Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics |
| title_full | Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics |
| title_fullStr | Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics |
| title_full_unstemmed | Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics |
| title_short | Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics |
| title_sort | toxic effects of amanitins repurposing toxicities toward new therapeutics |
| topic | amanitin hepatotoxicity <i>Amanita phalloïdes</i> antidote amanitin-conjugated antibody |
| url | https://www.mdpi.com/2072-6651/13/6/417 |
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