Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis
Abstract Background Genetic association of uncoupling proteins (UCPs) variants with the susceptibility of diabetic retinopathy (DR) in diabetes mellitus (DM) patients has been reported but with controversy. Here we aimed to conduct a meta-analysis to confirm the association of different UCPs variant...
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| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-021-01838-1 |
| _version_ | 1818665116440199168 |
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| author | Xujia Liu Zehua Jiang Guihua Zhang Tsz Kin Ng Zhenggen Wu |
| author_facet | Xujia Liu Zehua Jiang Guihua Zhang Tsz Kin Ng Zhenggen Wu |
| author_sort | Xujia Liu |
| collection | DOAJ |
| description | Abstract Background Genetic association of uncoupling proteins (UCPs) variants with the susceptibility of diabetic retinopathy (DR) in diabetes mellitus (DM) patients has been reported but with controversy. Here we aimed to conduct a meta-analysis to confirm the association of different UCPs variants with DR. Methods Three databases (Medline Ovid, Embase Ovid and CENTRAL) were applied in the literature search. Five genetic models, including allelic, homozygous, heterozygous, dominant and recessive models, were evaluated. Odds ratios (OR) were estimated under the random or fixed-effects models. Subgroup analyses, publication bias and sensitivity analyses were also conducted. Results Eleven studies on 2 UCPs variants (UCP1 rs1800592 and UCP2 rs659366) were included. Our meta-analysis showed that UCP1 rs1800592 was not associated with DR in type-2 DM patients, and UCP2 rs659366 also showed no association with DR. In the subgroup analyses on the stage of DR, allele G of UCP1 rs1800592 significantly increased the susceptibility of proliferative diabetic retinopathy (PDR) in type-2 DM patients in the allelic (OR = 1.26, P = 0.03) and homozygous models (OR = 1.60, P = 0.04). Subgroup analysis on ethnicity did not found any significant association of rs1800592 and rs659366 with DR. Conclusion Our meta-analysis confirmed the association of UCP1 rs1800592 variant with PDR in patients with type-2 DM, suggesting its potential as a genetic marker for PDR prediction in population screening. |
| first_indexed | 2024-12-17T05:43:31Z |
| format | Article |
| id | doaj.art-2b77d22521604e9989c6c6c4732e1c6b |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-17T05:43:31Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-2b77d22521604e9989c6c6c4732e1c6b2022-12-21T22:01:22ZengBMCBMC Ophthalmology1471-24152021-02-0121111210.1186/s12886-021-01838-1Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysisXujia Liu0Zehua Jiang1Guihua Zhang2Tsz Kin Ng3Zhenggen Wu4Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong KongJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong KongJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong KongJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong KongJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong KongAbstract Background Genetic association of uncoupling proteins (UCPs) variants with the susceptibility of diabetic retinopathy (DR) in diabetes mellitus (DM) patients has been reported but with controversy. Here we aimed to conduct a meta-analysis to confirm the association of different UCPs variants with DR. Methods Three databases (Medline Ovid, Embase Ovid and CENTRAL) were applied in the literature search. Five genetic models, including allelic, homozygous, heterozygous, dominant and recessive models, were evaluated. Odds ratios (OR) were estimated under the random or fixed-effects models. Subgroup analyses, publication bias and sensitivity analyses were also conducted. Results Eleven studies on 2 UCPs variants (UCP1 rs1800592 and UCP2 rs659366) were included. Our meta-analysis showed that UCP1 rs1800592 was not associated with DR in type-2 DM patients, and UCP2 rs659366 also showed no association with DR. In the subgroup analyses on the stage of DR, allele G of UCP1 rs1800592 significantly increased the susceptibility of proliferative diabetic retinopathy (PDR) in type-2 DM patients in the allelic (OR = 1.26, P = 0.03) and homozygous models (OR = 1.60, P = 0.04). Subgroup analysis on ethnicity did not found any significant association of rs1800592 and rs659366 with DR. Conclusion Our meta-analysis confirmed the association of UCP1 rs1800592 variant with PDR in patients with type-2 DM, suggesting its potential as a genetic marker for PDR prediction in population screening.https://doi.org/10.1186/s12886-021-01838-1Diabetic retinopathyUncoupling proteinsVariantsMeta-analysis |
| spellingShingle | Xujia Liu Zehua Jiang Guihua Zhang Tsz Kin Ng Zhenggen Wu Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis BMC Ophthalmology Diabetic retinopathy Uncoupling proteins Variants Meta-analysis |
| title | Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis |
| title_full | Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis |
| title_fullStr | Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis |
| title_full_unstemmed | Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis |
| title_short | Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis |
| title_sort | association of ucp1 and ucp2 variants with diabetic retinopathy susceptibility in type 2 diabetes mellitus patients a meta analysis |
| topic | Diabetic retinopathy Uncoupling proteins Variants Meta-analysis |
| url | https://doi.org/10.1186/s12886-021-01838-1 |
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