Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice
Peripheral neuropathy is a major dose-limiting side effect of the chemotherapeutic agent paclitaxel. This study examined whether the three related traditional herbal formulations, goshajinkigan (GJG; 牛車腎氣丸 Niú Chē Shèn Qì Wán), hachimijiogan (HJG; 八味地黃丸 Bā Wèi Dì Huáng Wán), and rokumigan (RMG; 六味丸...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-10-01
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| Series: | Journal of Traditional and Complementary Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411016302486 |
| _version_ | 1818584354487533568 |
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| author | Tsugunobu Andoh Ryo Kitamura Hirotoshi Fushimi Katsuko Komatsu Naotoshi Shibahara Yasushi Kuraishi |
| author_facet | Tsugunobu Andoh Ryo Kitamura Hirotoshi Fushimi Katsuko Komatsu Naotoshi Shibahara Yasushi Kuraishi |
| author_sort | Tsugunobu Andoh |
| collection | DOAJ |
| description | Peripheral neuropathy is a major dose-limiting side effect of the chemotherapeutic agent paclitaxel. This study examined whether the three related traditional herbal formulations, goshajinkigan (GJG; 牛車腎氣丸 Niú Chē Shèn Qì Wán), hachimijiogan (HJG; 八味地黃丸 Bā Wèi Dì Huáng Wán), and rokumigan (RMG; 六味丸 Liù Wèi Wán), would relieve paclitaxel-induced mechanical allodynia in mice. A single intraperitoneal injection of paclitaxel (5 mg/kg) induced mechanical allodynia, which peaked on day 14 after injection. On day 14 after paclitaxel injection, oral administration of GJG (0.1-1.0 g/kg) produced a significant inhibition of established allodynia, but HJG and RMG did not affect the allodynia. Repeated oral administration of GJG (0.1-1.0 g/kg) starting from the day after paclitaxel injection did not affect allodynia development, but significantly inhibited allodynia exacerbation. Repeated oral administration of HJG produced a slight inhibition of allodynia exacerbation, but that of RMG did not. These results suggest that prophylactic administration of GJG is effective in preventing the exacerbation of paclitaxel-induced allodynia. The herbal medicines Plantaginis Semen (車前子 Chē Qián Zǐ) and Achyranthis Radix (牛膝 Niú Xī), which are present in GJG but not in HJG, may contribute to the inhibitory action of GJG on the exacerbation of paclitaxel-induced allodynia. |
| first_indexed | 2024-12-16T08:19:51Z |
| format | Article |
| id | doaj.art-2b7846dcf79040b8801369e221ba201c |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-12-16T08:19:51Z |
| publishDate | 2014-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-2b7846dcf79040b8801369e221ba201c2022-12-21T22:38:09ZengElsevierJournal of Traditional and Complementary Medicine2225-41102014-10-014429329710.4103/2225-4110.128906Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in MiceTsugunobu Andoh0Ryo Kitamura1Hirotoshi Fushimi2Katsuko Komatsu3Naotoshi Shibahara4Yasushi Kuraishi5Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.Museum of Materia Medica, Research Center for Ethnomedicine, Institutes of Natural Medicine, University of Toyama, Toyama, Japan.Division of Pharmacognosy, Institutes of Natural Medicine, University of Toyama, Toyama, Japan.Division of Kampo Diagnostics, Institutes of Natural Medicine, University of Toyama, Toyama, Japan.Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.Peripheral neuropathy is a major dose-limiting side effect of the chemotherapeutic agent paclitaxel. This study examined whether the three related traditional herbal formulations, goshajinkigan (GJG; 牛車腎氣丸 Niú Chē Shèn Qì Wán), hachimijiogan (HJG; 八味地黃丸 Bā Wèi Dì Huáng Wán), and rokumigan (RMG; 六味丸 Liù Wèi Wán), would relieve paclitaxel-induced mechanical allodynia in mice. A single intraperitoneal injection of paclitaxel (5 mg/kg) induced mechanical allodynia, which peaked on day 14 after injection. On day 14 after paclitaxel injection, oral administration of GJG (0.1-1.0 g/kg) produced a significant inhibition of established allodynia, but HJG and RMG did not affect the allodynia. Repeated oral administration of GJG (0.1-1.0 g/kg) starting from the day after paclitaxel injection did not affect allodynia development, but significantly inhibited allodynia exacerbation. Repeated oral administration of HJG produced a slight inhibition of allodynia exacerbation, but that of RMG did not. These results suggest that prophylactic administration of GJG is effective in preventing the exacerbation of paclitaxel-induced allodynia. The herbal medicines Plantaginis Semen (車前子 Chē Qián Zǐ) and Achyranthis Radix (牛膝 Niú Xī), which are present in GJG but not in HJG, may contribute to the inhibitory action of GJG on the exacerbation of paclitaxel-induced allodynia.http://www.sciencedirect.com/science/article/pii/S2225411016302486GoshajinkiganHachimijioganMechanical allodyniaPaclitaxelRokumigan |
| spellingShingle | Tsugunobu Andoh Ryo Kitamura Hirotoshi Fushimi Katsuko Komatsu Naotoshi Shibahara Yasushi Kuraishi Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice Journal of Traditional and Complementary Medicine Goshajinkigan Hachimijiogan Mechanical allodynia Paclitaxel Rokumigan |
| title | Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice |
| title_full | Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice |
| title_fullStr | Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice |
| title_full_unstemmed | Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice |
| title_short | Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice |
| title_sort | effects of goshajinkigan hachimijiogan and rokumigan on mechanical allodynia induced by paclitaxel in mice |
| topic | Goshajinkigan Hachimijiogan Mechanical allodynia Paclitaxel Rokumigan |
| url | http://www.sciencedirect.com/science/article/pii/S2225411016302486 |
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