Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies
This systematic review provides an overview of the available evidence on the inter-individual variability (IIV) in the absorption, distribution, metabolism, and excretion (ADME) of phenolic metabolites and its determinants. Human studies were included investigating the metabolism and bioavailability...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231724000715 |
| _version_ | 1797235522185199616 |
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| author | Claudia Favari José Fernando Rinaldi de Alvarenga Lorena Sánchez-Martínez Nicole Tosi Cristiana Mignogna Eleonora Cremonini Claudine Manach Letizia Bresciani Daniele Del Rio Pedro Mena |
| author_facet | Claudia Favari José Fernando Rinaldi de Alvarenga Lorena Sánchez-Martínez Nicole Tosi Cristiana Mignogna Eleonora Cremonini Claudine Manach Letizia Bresciani Daniele Del Rio Pedro Mena |
| author_sort | Claudia Favari |
| collection | DOAJ |
| description | This systematic review provides an overview of the available evidence on the inter-individual variability (IIV) in the absorption, distribution, metabolism, and excretion (ADME) of phenolic metabolites and its determinants. Human studies were included investigating the metabolism and bioavailability of (poly)phenols and reporting IIV. One hundred fifty-three studies met the inclusion criteria. Inter-individual differences were mainly related to gut microbiota composition and activity but also to genetic polymorphisms, age, sex, ethnicity, BMI, (patho)physiological status, and physical activity, depending on the (poly)phenol sub-class considered. Most of the IIV has been poorly characterised. Two major types of IIV were observed. One resulted in metabolite gradients that can be further classified into high and low excretors, as seen for all flavonoids, phenolic acids, prenylflavonoids, alkylresorcinols, and hydroxytyrosol. The other type of IIV is based on clusters of individuals defined by qualitative differences (producers vs. non-producers), as for ellagitannins (urolithins), isoflavones (equol and O-DMA), resveratrol (lunularin), and preliminarily for avenanthramides (dihydro-avenanthramides), or by quali-quantitative metabotypes characterized by different proportions of specific metabolites, as for flavan-3-ols, flavanones, and even isoflavones. Future works are needed to shed light on current open issues limiting our understanding of this phenomenon that likely conditions the health effects of dietary (poly)phenols. |
| first_indexed | 2024-03-07T18:35:59Z |
| format | Article |
| id | doaj.art-2b796fd7a0ca493a8da0796255463988 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-04-24T16:49:18Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-2b796fd7a0ca493a8da07962554639882024-03-29T05:50:12ZengElsevierRedox Biology2213-23172024-05-0171103095Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studiesClaudia Favari0José Fernando Rinaldi de Alvarenga1Lorena Sánchez-Martínez2Nicole Tosi3Cristiana Mignogna4Eleonora Cremonini5Claudine Manach6Letizia Bresciani7Daniele Del Rio8Pedro Mena9Human Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, Italy; Corresponding author.Human Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, ItalyHuman Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, Italy; Department of Food Technology, Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence ‘Campus Mare Nostrum’, Biomedical Research Institute of Murcia (IMIB-Arrixaca-UMU), University Clinical Hospital ‘Virgen de La Arrixaca’, Universidad de Murcia, Espinardo, Murcia, SpainHuman Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, ItalyHuman Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, ItalyDepartment of Nutrition, University of California, Davis, CA, USA; Department of Environmental Toxicology, University of California, Davis, CA, USAUniversité Clermont Auvergne, INRAE, Human Nutrition Unit, Clermont-Ferrand, FranceHuman Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, ItalyHuman Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, Italy; Microbiome Research Hub, University of Parma, 43124, Parma, ItalyHuman Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, Italy; Microbiome Research Hub, University of Parma, 43124, Parma, ItalyThis systematic review provides an overview of the available evidence on the inter-individual variability (IIV) in the absorption, distribution, metabolism, and excretion (ADME) of phenolic metabolites and its determinants. Human studies were included investigating the metabolism and bioavailability of (poly)phenols and reporting IIV. One hundred fifty-three studies met the inclusion criteria. Inter-individual differences were mainly related to gut microbiota composition and activity but also to genetic polymorphisms, age, sex, ethnicity, BMI, (patho)physiological status, and physical activity, depending on the (poly)phenol sub-class considered. Most of the IIV has been poorly characterised. Two major types of IIV were observed. One resulted in metabolite gradients that can be further classified into high and low excretors, as seen for all flavonoids, phenolic acids, prenylflavonoids, alkylresorcinols, and hydroxytyrosol. The other type of IIV is based on clusters of individuals defined by qualitative differences (producers vs. non-producers), as for ellagitannins (urolithins), isoflavones (equol and O-DMA), resveratrol (lunularin), and preliminarily for avenanthramides (dihydro-avenanthramides), or by quali-quantitative metabotypes characterized by different proportions of specific metabolites, as for flavan-3-ols, flavanones, and even isoflavones. Future works are needed to shed light on current open issues limiting our understanding of this phenomenon that likely conditions the health effects of dietary (poly)phenols.http://www.sciencedirect.com/science/article/pii/S2213231724000715BioavailabilityGut microbiotaInter-person variationMetaboliteMetabotype(poly)phenol |
| spellingShingle | Claudia Favari José Fernando Rinaldi de Alvarenga Lorena Sánchez-Martínez Nicole Tosi Cristiana Mignogna Eleonora Cremonini Claudine Manach Letizia Bresciani Daniele Del Rio Pedro Mena Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies Redox Biology Bioavailability Gut microbiota Inter-person variation Metabolite Metabotype (poly)phenol |
| title | Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies |
| title_full | Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies |
| title_fullStr | Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies |
| title_full_unstemmed | Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies |
| title_short | Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies |
| title_sort | factors driving the inter individual variability in the metabolism and bioavailability of poly phenolic metabolites a systematic review of human studies |
| topic | Bioavailability Gut microbiota Inter-person variation Metabolite Metabotype (poly)phenol |
| url | http://www.sciencedirect.com/science/article/pii/S2213231724000715 |
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