Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray

Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray

The mechanism of action for a new lead stilbene compound coded SK-03-92 with bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) is unknown. To gain insight into the killing process, transcriptional profiling was performed on SK-03-92 treated vs. untreated S. aureus. Fou...

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Bibliographic Details
Main Authors: William R. Schwan, Rebecca Polanowski, Paul M. Dunman, Sara Medina-Bielski, Michelle Lane, Marc Rott, Lauren Lipker, Amy Wescott, Aaron Monte, James M. Cook, Douglas D. Baumann, V.V.N. Phani Babu Tiruveedhula, Christopher M. Witzigmann, Cassandra Mikel, Md Toufiqur Rahman
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Antibiotics
Subjects:
stilbene
microarray
Staphylococcus aureus
gene regulation
drug mechanism of action
sortase
biofilm
Online Access:https://www.mdpi.com/2079-6382/6/3/17

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