Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome?
Psoriasis is a systemic, immune-metabolic disease with strong genetic predispositions and autoimmune pathogenic traits. During psoriasis progression, a wide spectrum of comorbidities comes into play with the leading role of the cardio-metabolic syndrome (CMS) that occurs with the frequency of 30–50%...
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/10/3682 |
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| author | Julita Anna Krahel Anna Baran Tomasz W. Kamiński Iwona Flisiak |
| author_facet | Julita Anna Krahel Anna Baran Tomasz W. Kamiński Iwona Flisiak |
| author_sort | Julita Anna Krahel |
| collection | DOAJ |
| description | Psoriasis is a systemic, immune-metabolic disease with strong genetic predispositions and autoimmune pathogenic traits. During psoriasis progression, a wide spectrum of comorbidities comes into play with the leading role of the cardio-metabolic syndrome (CMS) that occurs with the frequency of 30–50% amongst the psoriatic patients. Both conditions—psoriasis and CMS—have numerous common pathways, mainly related to proinflammatory pathways and cytokine profiles. Surprisingly, despite the years of research, the exact pathways linking the occurrence of CMS in the psoriasis population are still not fully understood. Recently published papers, both clinical and based on the basic science, shed new light into this relationship providing an insight into novel key-players proteins with plausible effects on above-mentioned interplay. Taking into account recent advances in this important medical matter, this review aims to discuss comprehensively the role of four proteins: proprotein convertase subtilisin/kexin type-9 (PSCK9), angiopoietin-like protein 8 (ANGPLT8), sortilin (SORT1), and cholesteryl ester transfer proteins (CEPT) as plausible links between psoriasis and CMS. |
| first_indexed | 2024-03-10T19:37:26Z |
| format | Article |
| id | doaj.art-2b7b800626c748c79ea560b06d21af79 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:37:26Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2b7b800626c748c79ea560b06d21af792023-11-20T01:31:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110368210.3390/ijms21103682Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome?Julita Anna Krahel0Anna Baran1Tomasz W. Kamiński2Iwona Flisiak3Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15–540 Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15–540 Bialystok, PolandDepartment of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2c St., 15–222 Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15–540 Bialystok, PolandPsoriasis is a systemic, immune-metabolic disease with strong genetic predispositions and autoimmune pathogenic traits. During psoriasis progression, a wide spectrum of comorbidities comes into play with the leading role of the cardio-metabolic syndrome (CMS) that occurs with the frequency of 30–50% amongst the psoriatic patients. Both conditions—psoriasis and CMS—have numerous common pathways, mainly related to proinflammatory pathways and cytokine profiles. Surprisingly, despite the years of research, the exact pathways linking the occurrence of CMS in the psoriasis population are still not fully understood. Recently published papers, both clinical and based on the basic science, shed new light into this relationship providing an insight into novel key-players proteins with plausible effects on above-mentioned interplay. Taking into account recent advances in this important medical matter, this review aims to discuss comprehensively the role of four proteins: proprotein convertase subtilisin/kexin type-9 (PSCK9), angiopoietin-like protein 8 (ANGPLT8), sortilin (SORT1), and cholesteryl ester transfer proteins (CEPT) as plausible links between psoriasis and CMS.https://www.mdpi.com/1422-0067/21/10/3682psoriasismetabolic syndromeatherosclerosisPCSK9ANGPTL8CEPT |
| spellingShingle | Julita Anna Krahel Anna Baran Tomasz W. Kamiński Iwona Flisiak Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome? International Journal of Molecular Sciences psoriasis metabolic syndrome atherosclerosis PCSK9 ANGPTL8 CEPT |
| title | Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome? |
| title_full | Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome? |
| title_fullStr | Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome? |
| title_full_unstemmed | Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome? |
| title_short | Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome? |
| title_sort | proprotein convertase subtilisin kexin type 9 angiopoietin like protein 8 sortilin and cholesteryl ester transfer protein friends of foes for psoriatic patients at the risk of developing cardiometabolic syndrome |
| topic | psoriasis metabolic syndrome atherosclerosis PCSK9 ANGPTL8 CEPT |
| url | https://www.mdpi.com/1422-0067/21/10/3682 |
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