Infection of Chinese Rhesus Monkeys with a Subtype C SHIV Resulted in Attenuated In Vivo Viral Replication Despite Successful Animal-to-Animal Serial Passages

Infection of Chinese Rhesus Monkeys with a Subtype C SHIV Resulted in Attenuated In Vivo Viral Replication Despite Successful Animal-to-Animal Serial Passages

Rhesus macaques can be readily infected with chimeric simian-human immunodeficiency viruses (SHIV) as a suitable virus challenge system for testing the efficacy of HIV vaccines. Three Chinese-origin rhesus macaques (ChRM) were inoculated intravenously (IV) with SHIVC109P4 in a rapid serial in vivo p...

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Bibliographic Details
Main Authors: Gerald K. Chege, Craig H. Adams, Alana T. Keyser, Valerie Bekker, Lynn Morris, Francois J. Villinger, Anna-Lise Williamson, Rosamund E. Chapman
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Viruses
Subjects:
SHIV
subtype C
Chinese rhesus macaques
Online Access:https://www.mdpi.com/1999-4915/13/3/397

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