Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model
ABSTRACT: Background: Diabetes Mellitus is a progressive, chronic and multifactorial endocrine disorder characterized by elevated serum glucose levels. It has a direct effect to social and health related quality of life. Objective: This study aimed to determine the health-related quality of life am...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Current Therapeutic Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0011393X19300062 |
| _version_ | 1818135674973323264 |
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| author | Syed Wasif Gillani, PhD Irfan Altaf Ansari, MD Hisham A. Zaghloul, PharmD Syed Azhar Syed Sulaiman, PharmD Hassaan Anwar Rathore, PhD Mirza R. Baig, PhD Mohi Iqbal Mohammad Abdul, PhD Sultan Althagfan, PhD |
| author_facet | Syed Wasif Gillani, PhD Irfan Altaf Ansari, MD Hisham A. Zaghloul, PharmD Syed Azhar Syed Sulaiman, PharmD Hassaan Anwar Rathore, PhD Mirza R. Baig, PhD Mohi Iqbal Mohammad Abdul, PhD Sultan Althagfan, PhD |
| author_sort | Syed Wasif Gillani, PhD |
| collection | DOAJ |
| description | ABSTRACT: Background: Diabetes Mellitus is a progressive, chronic and multifactorial endocrine disorder characterized by elevated serum glucose levels. It has a direct effect to social and health related quality of life. Objective: This study aimed to determine the health-related quality of life among patients with type II diabetes mellitus (T2DM) using insulin therapy. Methods: Cross-sectional observational study design was used to collect data from Malaysian patients with T2DM. Subjective and objective assessments were made either by using several questionnaires or each patient's specific medication profile registered to care sites. Study participants were recruited from both public hospitals and community health clinics located in Kuala Lumpur, Malaysia. Results: A total of 430 patients with T2DM were recruited in this study with a response rate of 94.7%. The oral antidiabetic medication (OAM) group consisted of 63.0% of the study population and the rest (37.0%) were Insulin users. The body mass index and glycosylated hemoglobin patterns were significantly different between groups (P < 0.011 and P < 0.001). Insulin users showed high percentages of healthy body mass index index (44.7%) compared with OAM users (35.8%) and controlled glycemic index (glycosylated hemoglobin ≤7.5%) was significantly (P = 0.001) better among the insulin-user group compared with the OAM group. The Euro Quality of Life–5 dimension domain analysis indicated significant differences with domains of usual work (P < 0.047), pain and discomfort (P < 0.041), and anxiety and depression (P < 0.001) among insulin users versus OAM users. We also observed a significant difference between the groups regarding diet, monitoring, and disease-specific knowledge. The mean (SD) adherence score showed that insulin users were significantly (P < 0.001) more adherent (6.09 [2.98]) than OAM were nonadherent (4.19 [4.68]). Conclusions: This study suggests the valuable effect of insulin therapy among patients with T2DM compared with OAMs on health-related quality of life, medication adherence, and health state. Insulin users reported they had better diabetes-related knowledge and treatment adherence characteristics than noninsulin users. Key words: Adherence, Cross-sectional study, Diabetes knowledge, Health perception, Health care quality of life, Insulin use |
| first_indexed | 2024-12-11T09:28:16Z |
| format | Article |
| id | doaj.art-2b7d7d3312db4a75bdc25be23df609c6 |
| institution | Directory Open Access Journal |
| issn | 0011-393X |
| language | English |
| last_indexed | 2024-12-11T09:28:16Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Therapeutic Research |
| spelling | doaj.art-2b7d7d3312db4a75bdc25be23df609c62022-12-22T01:13:04ZengElsevierCurrent Therapeutic Research0011-393X2019-01-01905360Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional ModelSyed Wasif Gillani, PhD0Irfan Altaf Ansari, MD1Hisham A. Zaghloul, PharmD2Syed Azhar Syed Sulaiman, PharmD3Hassaan Anwar Rathore, PhD4Mirza R. Baig, PhD5Mohi Iqbal Mohammad Abdul, PhD6Sultan Althagfan, PhD7Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al Munawarrah, Kingdom of Saudi Arabia; Address correspondence to: Syed Wasif Gillani, PhD, Department of Clinical and Hospital Pharmacy, College of Pharmacy, PO Box 41411, Taibah University, Al-Madinah Al Munawarrah, Saudi Arabia.Department of Pathology, College of Medicine, Taibah University, Al-Madinah Al Munawarrah, Kingdom of Saudi ArabiaDepartment of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al Munawarrah, Kingdom of Saudi ArabiaSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, MalaysiaAddress correspondence to: Syed Wasif Gillani, PhD, Department of Clinical and Hospital Pharmacy, College of Pharmacy, PO Box 41411, Taibah University, Al-Madinah Al Munawarrah, Saudi Arabia.; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, MalaysiaDubai Pharmacy College, Dubai, United Arab EmiratesDepartment of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al Munawarrah, Kingdom of Saudi ArabiaDepartment of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al Munawarrah, Kingdom of Saudi ArabiaABSTRACT: Background: Diabetes Mellitus is a progressive, chronic and multifactorial endocrine disorder characterized by elevated serum glucose levels. It has a direct effect to social and health related quality of life. Objective: This study aimed to determine the health-related quality of life among patients with type II diabetes mellitus (T2DM) using insulin therapy. Methods: Cross-sectional observational study design was used to collect data from Malaysian patients with T2DM. Subjective and objective assessments were made either by using several questionnaires or each patient's specific medication profile registered to care sites. Study participants were recruited from both public hospitals and community health clinics located in Kuala Lumpur, Malaysia. Results: A total of 430 patients with T2DM were recruited in this study with a response rate of 94.7%. The oral antidiabetic medication (OAM) group consisted of 63.0% of the study population and the rest (37.0%) were Insulin users. The body mass index and glycosylated hemoglobin patterns were significantly different between groups (P < 0.011 and P < 0.001). Insulin users showed high percentages of healthy body mass index index (44.7%) compared with OAM users (35.8%) and controlled glycemic index (glycosylated hemoglobin ≤7.5%) was significantly (P = 0.001) better among the insulin-user group compared with the OAM group. The Euro Quality of Life–5 dimension domain analysis indicated significant differences with domains of usual work (P < 0.047), pain and discomfort (P < 0.041), and anxiety and depression (P < 0.001) among insulin users versus OAM users. We also observed a significant difference between the groups regarding diet, monitoring, and disease-specific knowledge. The mean (SD) adherence score showed that insulin users were significantly (P < 0.001) more adherent (6.09 [2.98]) than OAM were nonadherent (4.19 [4.68]). Conclusions: This study suggests the valuable effect of insulin therapy among patients with T2DM compared with OAMs on health-related quality of life, medication adherence, and health state. Insulin users reported they had better diabetes-related knowledge and treatment adherence characteristics than noninsulin users. Key words: Adherence, Cross-sectional study, Diabetes knowledge, Health perception, Health care quality of life, Insulin usehttp://www.sciencedirect.com/science/article/pii/S0011393X19300062 |
| spellingShingle | Syed Wasif Gillani, PhD Irfan Altaf Ansari, MD Hisham A. Zaghloul, PharmD Syed Azhar Syed Sulaiman, PharmD Hassaan Anwar Rathore, PhD Mirza R. Baig, PhD Mohi Iqbal Mohammad Abdul, PhD Sultan Althagfan, PhD Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model Current Therapeutic Research |
| title | Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model |
| title_full | Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model |
| title_fullStr | Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model |
| title_full_unstemmed | Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model |
| title_short | Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model |
| title_sort | predictors of health related quality of life among patients with type ii diabetes mellitus who are insulin users a multidimensional model |
| url | http://www.sciencedirect.com/science/article/pii/S0011393X19300062 |
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