Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like <i>Klebsiella pneumoniae</i> Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring
Bacteremia and ventilator-associated pneumonia due to a pan-resistant <i>Klebsiella pneumoniae</i> strain co-producing KPC and OXA-48 carbapenemases was successfully treated in a COVID-19 critically ill patient with a combination therapy of a high-dose continuous infusion of meropenem (u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Infectious Disease Reports |
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| Online Access: | https://www.mdpi.com/2036-7449/14/1/10 |
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| author | Pier Giorgio Cojutti Giacomo Fornaro Milo Gatti Matteo Rinaldi Paolo Gaibani Maddalena Giannella Federico Pea Pierluigi Viale |
| author_facet | Pier Giorgio Cojutti Giacomo Fornaro Milo Gatti Matteo Rinaldi Paolo Gaibani Maddalena Giannella Federico Pea Pierluigi Viale |
| author_sort | Pier Giorgio Cojutti |
| collection | DOAJ |
| description | Bacteremia and ventilator-associated pneumonia due to a pan-resistant <i>Klebsiella pneumoniae</i> strain co-producing KPC and OXA-48 carbapenemases was successfully treated in a COVID-19 critically ill patient with a combination therapy of a high-dose continuous infusion of meropenem (up to 3 g every 6 h, daily) plus fosfomycin (up to 24 g/daily) that was guided by real-time therapeutic drug monitoring. Clinical pharmacological advice was helpful in maximizing, over time, the pharmacodynamic target attainment of both antibiotics. |
| first_indexed | 2024-03-09T21:47:04Z |
| format | Article |
| id | doaj.art-2b7f1284b7874c03848919cac90add29 |
| institution | Directory Open Access Journal |
| issn | 2036-7449 |
| language | English |
| last_indexed | 2024-03-09T21:47:04Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj.art-2b7f1284b7874c03848919cac90add292023-11-23T20:14:04ZengMDPI AGInfectious Disease Reports2036-74492022-01-01141889210.3390/idr14010010Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like <i>Klebsiella pneumoniae</i> Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug MonitoringPier Giorgio Cojutti0Giacomo Fornaro1Milo Gatti2Matteo Rinaldi3Paolo Gaibani4Maddalena Giannella5Federico Pea6Pierluigi Viale7SSD Clinical Pharmacology, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, ItalySSD Clinical Pharmacology, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, ItalyDivision of Microbiology, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, ItalySSD Clinical Pharmacology, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, ItalyBacteremia and ventilator-associated pneumonia due to a pan-resistant <i>Klebsiella pneumoniae</i> strain co-producing KPC and OXA-48 carbapenemases was successfully treated in a COVID-19 critically ill patient with a combination therapy of a high-dose continuous infusion of meropenem (up to 3 g every 6 h, daily) plus fosfomycin (up to 24 g/daily) that was guided by real-time therapeutic drug monitoring. Clinical pharmacological advice was helpful in maximizing, over time, the pharmacodynamic target attainment of both antibiotics.https://www.mdpi.com/2036-7449/14/1/10continuous infusion of meropenemtherapeutic drug monitoringcritically ill patient |
| spellingShingle | Pier Giorgio Cojutti Giacomo Fornaro Milo Gatti Matteo Rinaldi Paolo Gaibani Maddalena Giannella Federico Pea Pierluigi Viale Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like <i>Klebsiella pneumoniae</i> Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring Infectious Disease Reports continuous infusion of meropenem therapeutic drug monitoring critically ill patient |
| title | Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like <i>Klebsiella pneumoniae</i> Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring |
| title_full | Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like <i>Klebsiella pneumoniae</i> Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring |
| title_fullStr | Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like <i>Klebsiella pneumoniae</i> Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring |
| title_full_unstemmed | Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like <i>Klebsiella pneumoniae</i> Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring |
| title_short | Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like <i>Klebsiella pneumoniae</i> Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring |
| title_sort | successful treatment of bacteremia and ventilator associated pneumonia caused by kpc oxa 48 like i klebsiella pneumoniae i co producer with a continuous infusion of high dose meropenem plus fosfomycin guided by real time therapeutic drug monitoring |
| topic | continuous infusion of meropenem therapeutic drug monitoring critically ill patient |
| url | https://www.mdpi.com/2036-7449/14/1/10 |
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