The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial
Huan He,1 Qichun Cui,1 Hengheng Chen,2,* Xiao Huang,3,* Shuai Wang,3,* Tian Yu,2,* Jinqiu Feng,3 Yun Shao1 1Department of Anesthesiology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200002, People’s Republic of China; 2Dep...
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Dove Medical Press
2023-11-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/the-effect-of-intranasal-dexmedetomidine-on-emergence-delirium-prevent-peer-reviewed-fulltext-article-DDDT |
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| author | He H Cui Q Chen H Huang X Wang S Yu T Feng J Shao Y |
| author_facet | He H Cui Q Chen H Huang X Wang S Yu T Feng J Shao Y |
| author_sort | He H |
| collection | DOAJ |
| description | Huan He,1 Qichun Cui,1 Hengheng Chen,2,* Xiao Huang,3,* Shuai Wang,3,* Tian Yu,2,* Jinqiu Feng,3 Yun Shao1 1Department of Anesthesiology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200002, People’s Republic of China; 2Department of Preventive Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200002, People’s Republic of China; 3Department of Pediatric Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yun Shao, Department of Anesthesiology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, No. 356 East Beijing Road, Shanghai, 200002, People’s Republic of China, Tel/Fax +86 2163295852, Email shaoyun07078@sina.com Jinqiu Feng, Department of Pediatric Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, No 356 East Beijing Road, Shanghai, 200002, People’s Republic of China, Tel/Fax +86 2163601149, Email feng_jinqiu356@fudan.edu.cnPurpose: Sevoflurane is the preferred anesthetic agent for induction and maintenance of ambulatory surgery due to its property of fast onset and recovery. However, it has been recognized as one of the major contributors of emergence delirium. The aim of this study was to evaluate the preventive effect of intranasal dexmedetomidine on the occurrence of emergence delirium in pediatric patients under general anesthesia with sevoflurane.Patients and Methods: Ninety pediatric patients undergoing dental rehabilitation under sevoflurane anesthesia were enrolled in this study. The patients were divided into three groups (n=30 each in the 2 μg/kg dexmedetomidine, 1 μg/kg dexmedetomidine, and control with saline groups). The same volume (0.02mL/kg) of the mixed solution was dropped into the nasal cavity of the children 30 minutes before surgery. We used the Pediatric Anesthesia Emergence Delirium Scale (PAED) to assess the level and incidence of delirium in the post-anesthesia care unit.Results: Compared with the control group, prophylactic use of different dosages of intranasal dexmedetomidine significantly reduces the incidence of ED and severe ED in PACU (P< 0.001). Intranasal administration of 2 μg/kg dexmedetomidine was associated with a better acceptance of mask induction and a better tolerance of separation with parents.Conclusion: Both 2 μg/kg and 1 μg/kg intranasal dexmedetomidine can achieve ED preventive effects in PACU in dental rehabilitation under general anesthesia. A dosage of 2 μg/kg is more effective in preventing severe ED and providing better mask acceptance.Keywords: intranasal dexmedetomidine, emergence delirium, sevoflurane anesthesia, pediatric patients, dental rehabilitation |
| first_indexed | 2024-03-09T13:55:50Z |
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| institution | Directory Open Access Journal |
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| last_indexed | 2024-03-09T13:55:50Z |
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| series | Drug Design, Development and Therapy |
| spelling | doaj.art-2b7f59a2e0364349a279cc053c774b592023-11-30T18:44:06ZengDove Medical PressDrug Design, Development and Therapy1177-88812023-11-01Volume 173563357088599The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical TrialHe HCui QChen HHuang XWang SYu TFeng JShao YHuan He,1 Qichun Cui,1 Hengheng Chen,2,* Xiao Huang,3,* Shuai Wang,3,* Tian Yu,2,* Jinqiu Feng,3 Yun Shao1 1Department of Anesthesiology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200002, People’s Republic of China; 2Department of Preventive Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200002, People’s Republic of China; 3Department of Pediatric Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yun Shao, Department of Anesthesiology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, No. 356 East Beijing Road, Shanghai, 200002, People’s Republic of China, Tel/Fax +86 2163295852, Email shaoyun07078@sina.com Jinqiu Feng, Department of Pediatric Dentistry, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, No 356 East Beijing Road, Shanghai, 200002, People’s Republic of China, Tel/Fax +86 2163601149, Email feng_jinqiu356@fudan.edu.cnPurpose: Sevoflurane is the preferred anesthetic agent for induction and maintenance of ambulatory surgery due to its property of fast onset and recovery. However, it has been recognized as one of the major contributors of emergence delirium. The aim of this study was to evaluate the preventive effect of intranasal dexmedetomidine on the occurrence of emergence delirium in pediatric patients under general anesthesia with sevoflurane.Patients and Methods: Ninety pediatric patients undergoing dental rehabilitation under sevoflurane anesthesia were enrolled in this study. The patients were divided into three groups (n=30 each in the 2 μg/kg dexmedetomidine, 1 μg/kg dexmedetomidine, and control with saline groups). The same volume (0.02mL/kg) of the mixed solution was dropped into the nasal cavity of the children 30 minutes before surgery. We used the Pediatric Anesthesia Emergence Delirium Scale (PAED) to assess the level and incidence of delirium in the post-anesthesia care unit.Results: Compared with the control group, prophylactic use of different dosages of intranasal dexmedetomidine significantly reduces the incidence of ED and severe ED in PACU (P< 0.001). Intranasal administration of 2 μg/kg dexmedetomidine was associated with a better acceptance of mask induction and a better tolerance of separation with parents.Conclusion: Both 2 μg/kg and 1 μg/kg intranasal dexmedetomidine can achieve ED preventive effects in PACU in dental rehabilitation under general anesthesia. A dosage of 2 μg/kg is more effective in preventing severe ED and providing better mask acceptance.Keywords: intranasal dexmedetomidine, emergence delirium, sevoflurane anesthesia, pediatric patients, dental rehabilitationhttps://www.dovepress.com/the-effect-of-intranasal-dexmedetomidine-on-emergence-delirium-prevent-peer-reviewed-fulltext-article-DDDTintranasal dexmedetomidineemergence deliriumsevoflurane anesthesiapediatric patientsdental rehabilitation. |
| spellingShingle | He H Cui Q Chen H Huang X Wang S Yu T Feng J Shao Y The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial Drug Design, Development and Therapy intranasal dexmedetomidine emergence delirium sevoflurane anesthesia pediatric patients dental rehabilitation. |
| title | The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial |
| title_full | The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial |
| title_fullStr | The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial |
| title_full_unstemmed | The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial |
| title_short | The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial |
| title_sort | effect of intranasal dexmedetomidine on emergence delirium prevention in pediatric ambulatory dental rehabilitation under general anesthesia a randomized clinical trial |
| topic | intranasal dexmedetomidine emergence delirium sevoflurane anesthesia pediatric patients dental rehabilitation. |
| url | https://www.dovepress.com/the-effect-of-intranasal-dexmedetomidine-on-emergence-delirium-prevent-peer-reviewed-fulltext-article-DDDT |
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