Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients
Objectives: The detection of dyskinesias-reduced-self-awareness (DRSA), in Parkinson’s disease (PD), was previously associated to executive and metacognitive deficits mainly due to dopaminergic overstimulation of mesocorticolimbic circuits. Response-inhibition dysfunction is often observed in PD. Ap...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2018.01765/full |
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| author | Sara Palermo Leonardo Lopiano Leonardo Lopiano Rosalba Morese Rosalba Morese Maurizio Zibetti Alberto Romagnolo Mario Stanziano Mario Giorgio Rizzone Giuliano Carlo Geminiani Giuliano Carlo Geminiani Maria Consuelo Valentini Martina Amanzio Martina Amanzio Martina Amanzio |
| author_facet | Sara Palermo Leonardo Lopiano Leonardo Lopiano Rosalba Morese Rosalba Morese Maurizio Zibetti Alberto Romagnolo Mario Stanziano Mario Giorgio Rizzone Giuliano Carlo Geminiani Giuliano Carlo Geminiani Maria Consuelo Valentini Martina Amanzio Martina Amanzio Martina Amanzio |
| author_sort | Sara Palermo |
| collection | DOAJ |
| description | Objectives: The detection of dyskinesias-reduced-self-awareness (DRSA), in Parkinson’s disease (PD), was previously associated to executive and metacognitive deficits mainly due to dopaminergic overstimulation of mesocorticolimbic circuits. Response-inhibition dysfunction is often observed in PD. Apart from being engaged in response-inhibition tasks, the anterior cingulate cortex (ACC), is part of a functional system based on self-awareness and engaged across cognitive, affective and behavioural contexts. The purpose of the study was to examine the relationship between response-inhibition disabilities and DRSA using whole-brain event-related functional magnetic resonance imaging (fMRI), over the course of a specific executive task.Methods: Twenty-seven cognitively preserved idiopathic PD patients – presenting motor fluctuations and dyskinesias – were studied. They underwent a neurological and neuropsychological evaluation. The presence of DRSA was assessed using the Dyskinesias Subtracted-Index (DS-I). Cingulate functionality was evaluated with fMRI, while patients performed an ACC-sensitive GO-NoGO task. Association between blood oxygenation level dependent response over the whole-brain during the response-inhibition task and DS-I scores was investigated by regression analysis.Results: The presence of DRSA was associated with reduced functional recruitment in the bilateral ACC, bilateral anterior insular cortex and right dorsolateral prefrontal cortex (pFWE<0.05). Moreover, DS-I scores significantly correlated with percent errors on the NoGO condition (r = 0.491, pFWE = 0.009).Discussion: These preliminary findings add evidence to the relevant role of executive dysfunctions in DRSA pathogenesis beyond the effects of chronic dopaminergic treatment, with a key leading role played by ACC as part of a functionally impaired response-inhibition network. Imaging biomarkers for DRSA are important to be studied, especially when the neuropsychological assessment seems to be normal. |
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| format | Article |
| id | doaj.art-2b815483f551476fb8954044ffc2e4d3 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-13T11:42:30Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-2b815483f551476fb8954044ffc2e4d32022-12-22T02:48:15ZengFrontiers Media S.A.Frontiers in Psychology1664-10782018-09-01910.3389/fpsyg.2018.01765361122Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease PatientsSara Palermo0Leonardo Lopiano1Leonardo Lopiano2Rosalba Morese3Rosalba Morese4Maurizio Zibetti5Alberto Romagnolo6Mario Stanziano7Mario Giorgio Rizzone8Giuliano Carlo Geminiani9Giuliano Carlo Geminiani10Maria Consuelo Valentini11Martina Amanzio12Martina Amanzio13Martina Amanzio14Department of Psychology, University of Turin, Turin, ItalyDepartment of Neuroscience, University of Turin, Turin, ItalyNeuroscience Institute of Turin, University of Turin, Turin, ItalyDepartment of Psychology, University of Turin, Turin, ItalyFaculty of Communication Sciences, Università della Svizzera Italiana, Lugano, SwitzerlandDepartment of Neuroscience, University of Turin, Turin, ItalyDepartment of Neuroscience, University of Turin, Turin, ItalyAzienda Ospedaliera Universitaria “Città della Salute e della Scienza di Torino”, Neuroradiology Unit, Turin, ItalyDepartment of Neuroscience, University of Turin, Turin, ItalyDepartment of Psychology, University of Turin, Turin, ItalyNeuroscience Institute of Turin, University of Turin, Turin, ItalyAzienda Ospedaliera Universitaria “Città della Salute e della Scienza di Torino”, Neuroradiology Unit, Turin, ItalyDepartment of Psychology, University of Turin, Turin, ItalyNeuroscience Institute of Turin, University of Turin, Turin, ItalyEuropean Innovation Partnership on Active and Healthy Ageing, Bruxelles, BelgiumObjectives: The detection of dyskinesias-reduced-self-awareness (DRSA), in Parkinson’s disease (PD), was previously associated to executive and metacognitive deficits mainly due to dopaminergic overstimulation of mesocorticolimbic circuits. Response-inhibition dysfunction is often observed in PD. Apart from being engaged in response-inhibition tasks, the anterior cingulate cortex (ACC), is part of a functional system based on self-awareness and engaged across cognitive, affective and behavioural contexts. The purpose of the study was to examine the relationship between response-inhibition disabilities and DRSA using whole-brain event-related functional magnetic resonance imaging (fMRI), over the course of a specific executive task.Methods: Twenty-seven cognitively preserved idiopathic PD patients – presenting motor fluctuations and dyskinesias – were studied. They underwent a neurological and neuropsychological evaluation. The presence of DRSA was assessed using the Dyskinesias Subtracted-Index (DS-I). Cingulate functionality was evaluated with fMRI, while patients performed an ACC-sensitive GO-NoGO task. Association between blood oxygenation level dependent response over the whole-brain during the response-inhibition task and DS-I scores was investigated by regression analysis.Results: The presence of DRSA was associated with reduced functional recruitment in the bilateral ACC, bilateral anterior insular cortex and right dorsolateral prefrontal cortex (pFWE<0.05). Moreover, DS-I scores significantly correlated with percent errors on the NoGO condition (r = 0.491, pFWE = 0.009).Discussion: These preliminary findings add evidence to the relevant role of executive dysfunctions in DRSA pathogenesis beyond the effects of chronic dopaminergic treatment, with a key leading role played by ACC as part of a functionally impaired response-inhibition network. Imaging biomarkers for DRSA are important to be studied, especially when the neuropsychological assessment seems to be normal.https://www.frontiersin.org/article/10.3389/fpsyg.2018.01765/fullParkinson’s Diseasedyskinesiasself-awarenessresponse-inhibitionfMRI |
| spellingShingle | Sara Palermo Leonardo Lopiano Leonardo Lopiano Rosalba Morese Rosalba Morese Maurizio Zibetti Alberto Romagnolo Mario Stanziano Mario Giorgio Rizzone Giuliano Carlo Geminiani Giuliano Carlo Geminiani Maria Consuelo Valentini Martina Amanzio Martina Amanzio Martina Amanzio Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients Frontiers in Psychology Parkinson’s Disease dyskinesias self-awareness response-inhibition fMRI |
| title | Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients |
| title_full | Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients |
| title_fullStr | Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients |
| title_full_unstemmed | Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients |
| title_short | Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients |
| title_sort | role of the cingulate cortex in dyskinesias reduced self awareness an fmri study on parkinson s disease patients |
| topic | Parkinson’s Disease dyskinesias self-awareness response-inhibition fMRI |
| url | https://www.frontiersin.org/article/10.3389/fpsyg.2018.01765/full |
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