Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as first line of defense in the innate arm of the immune system. They capture and destroy invading microorganisms, through phagocytosis and intracellular degradation, release of granules, and formation of neutrop...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.00113/full |
| _version_ | 1831811539204571136 |
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| author | Carlos Rosales |
| author_facet | Carlos Rosales |
| author_sort | Carlos Rosales |
| collection | DOAJ |
| description | Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as first line of defense in the innate arm of the immune system. They capture and destroy invading microorganisms, through phagocytosis and intracellular degradation, release of granules, and formation of neutrophil extracellular traps after detecting pathogens. Neutrophils also participate as mediators of inflammation. The classical view for these leukocytes is that neutrophils constitute a homogenous population of terminally differentiated cells with a unique function. However, evidence accumulated in recent years, has revealed that neutrophils present a large phenotypic heterogeneity and functional versatility, which place neutrophils as important modulators of both inflammation and immune responses. Indeed, the roles played by neutrophils in homeostatic conditions as well as in pathological inflammation and immune processes are the focus of a renovated interest in neutrophil biology. In this review, I present the concept of neutrophil phenotypic and functional heterogeneity and describe several neutrophil subpopulations reported to date. I also discuss the role these subpopulations seem to play in homeostasis and disease. |
| first_indexed | 2024-12-22T21:20:12Z |
| format | Article |
| id | doaj.art-2b81dd36897c4784b52694e861abd20e |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T21:20:12Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-2b81dd36897c4784b52694e861abd20e2022-12-21T18:12:13ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-02-01910.3389/fphys.2018.00113324475Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?Carlos RosalesNeutrophils are the most abundant leukocytes in the circulation, and have been regarded as first line of defense in the innate arm of the immune system. They capture and destroy invading microorganisms, through phagocytosis and intracellular degradation, release of granules, and formation of neutrophil extracellular traps after detecting pathogens. Neutrophils also participate as mediators of inflammation. The classical view for these leukocytes is that neutrophils constitute a homogenous population of terminally differentiated cells with a unique function. However, evidence accumulated in recent years, has revealed that neutrophils present a large phenotypic heterogeneity and functional versatility, which place neutrophils as important modulators of both inflammation and immune responses. Indeed, the roles played by neutrophils in homeostatic conditions as well as in pathological inflammation and immune processes are the focus of a renovated interest in neutrophil biology. In this review, I present the concept of neutrophil phenotypic and functional heterogeneity and describe several neutrophil subpopulations reported to date. I also discuss the role these subpopulations seem to play in homeostasis and disease.https://www.frontiersin.org/article/10.3389/fphys.2018.00113/fullneutrophilbacteriainfectioninflammationcancer |
| spellingShingle | Carlos Rosales Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? Frontiers in Physiology neutrophil bacteria infection inflammation cancer |
| title | Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? |
| title_full | Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? |
| title_fullStr | Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? |
| title_full_unstemmed | Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? |
| title_short | Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? |
| title_sort | neutrophil a cell with many roles in inflammation or several cell types |
| topic | neutrophil bacteria infection inflammation cancer |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.00113/full |
| work_keys_str_mv | AT carlosrosales neutrophilacellwithmanyrolesininflammationorseveralcelltypes |