Characterization of the Rifamycin-Degrading Monooxygenase From Rifamycin Producers Implicating Its Involvement in Saliniketal Biosynthesis

Characterization of the Rifamycin-Degrading Monooxygenase From Rifamycin Producers Implicating Its Involvement in Saliniketal Biosynthesis

Rifamycin derivatives, such as rifampicin, have potent antibiotic activity and have long been used in the clinic as mainstay components for the treatment of tuberculosis, leprosy, and AIDS-associated mycobacterial infections. However, the extensive usage of these antibiotics has resulted in the rapi...

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Bibliographic Details
Main Authors: Xiao-Fu Zheng, Xin-Qiang Liu, Shu-Ya Peng, Qiang Zhou, Bin Xu, Hua Yuan, Gong-Li Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
rifamycin degradation
Rox enzyme
flavin monooxygenase
self-resistance
saliniketal
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00971/full

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