| Summary: | Octacalcium phosphate (OCP) has attracted attention as a bone-repairing material with excellent bone regeneration ability, and F− incorporation is expected to further promote bone formation. However, because OCP is easily converted to fluorapatite in an aqueous fluoride solution, it is difficult to incorporate a large amount of F− while maintaining the crystalline structure of OCP. Therefore, in this study, we attempted to introduce F− into OCP using an ionic liquid with high F− concentration in a non-aqueous environment. OCP was incorporated with F− in the form of ion pairs after treatment with an acetone solution of 1-ethyl-3-methylimidazolium tetrafluoroborate. The F− content was approximately 9%, which was approximately 28 times greater than achieved in previous studies. The amount of OCP with F− dissolved in acetate buffer was less than that of untreated OCP.
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