Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants
Background We aimed at investigating the association of circulating fatty acids with coronary heart disease (CHD) and stroke risk. Methods and Results We conducted an individual‐participant data meta‐analysis of 5 UK‐based cohorts and 1 matched case‐control study. Fatty acids (ie, omega‐3 docosahexa...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.013131 |
| _version_ | 1818314992151166976 |
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| author | Maria Carolina Borges Amand Floriaan Schmidt Barbara Jefferis S. Goya Wannamethee Debbie A. Lawlor Mika Kivimaki Meena Kumari Tom R. Gaunt Yoav Ben‐Shlomo Therese Tillin Usha Menon Rui Providencia Caroline Dale Aleksandra Gentry‐Maharaj Alun Hughes Nish Chaturvedi Juan Pablo Casas Aroon D. Hingorani |
| author_facet | Maria Carolina Borges Amand Floriaan Schmidt Barbara Jefferis S. Goya Wannamethee Debbie A. Lawlor Mika Kivimaki Meena Kumari Tom R. Gaunt Yoav Ben‐Shlomo Therese Tillin Usha Menon Rui Providencia Caroline Dale Aleksandra Gentry‐Maharaj Alun Hughes Nish Chaturvedi Juan Pablo Casas Aroon D. Hingorani |
| author_sort | Maria Carolina Borges |
| collection | DOAJ |
| description | Background We aimed at investigating the association of circulating fatty acids with coronary heart disease (CHD) and stroke risk. Methods and Results We conducted an individual‐participant data meta‐analysis of 5 UK‐based cohorts and 1 matched case‐control study. Fatty acids (ie, omega‐3 docosahexaenoic acid, omega‐6 linoleic acid, monounsaturated and saturated fatty acids) were measured at baseline using an automated high‐throughput serum nuclear magnetic resonance metabolomics platform. Data from 3022 incident CHD cases (13 104 controls) and 1606 incident stroke cases (13 369 controls) were included. Logistic regression was used to model the relation between fatty acids and odds of CHD and stroke, adjusting for demographic and lifestyle variables only (ie, minimally adjusted model) or with further adjustment for other fatty acids (ie, fully adjusted model). Although circulating docosahexaenoic acid, but not linoleic acid, was related to lower CHD risk in the fully adjusted model (odds ratio, 0.85; 95% CI, 0.76–0.95 per standard unit of docosahexaenoic acid), there was evidence of high between‐study heterogeneity and effect modification by study design. Stroke risk was consistently lower with increasing circulating linoleic acid (odds ratio for fully adjusted model, 0.82; 95% CI, 0.75–0.90). Circulating monounsaturated fatty acids were associated with higher CHD risk across all models and with stroke risk in the fully adjusted model (odds ratio, 1.22; 95% CI, 1.03–1.44). Saturated fatty acids were not related to increased CHD risk in the fully adjusted model (odds ratio, 0.94; 95% CI, 0.82–1.09), or stroke risk. Conclusions We found consistent evidence that linoleic acid was associated with decreased risk of stroke and that monounsaturated fatty acids were associated with increased risk of CHD. The different pattern between CHD and stroke in terms of fatty acids risk profile suggests future studies should be cautious about using composite events. Different study designs are needed to assess which, if any, of the associations observed is causal. |
| first_indexed | 2024-12-13T08:58:27Z |
| format | Article |
| id | doaj.art-2b89a2e73e654ebeaff703406aae7316 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T08:58:27Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-2b89a2e73e654ebeaff703406aae73162022-12-21T23:53:12ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-03-019510.1161/JAHA.119.013131Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 ParticipantsMaria Carolina Borges0Amand Floriaan Schmidt1Barbara Jefferis2S. Goya Wannamethee3Debbie A. Lawlor4Mika Kivimaki5Meena Kumari6Tom R. Gaunt7Yoav Ben‐Shlomo8Therese Tillin9Usha Menon10Rui Providencia11Caroline Dale12Aleksandra Gentry‐Maharaj13Alun Hughes14Nish Chaturvedi15Juan Pablo Casas16Aroon D. Hingorani17MRC Integrative Epidemiology Unit at the University of Bristol United KingdomInstitute of Cardiovascular Science University College London London United KingdomUCL Department of Primary Care & Population Health UCL Medical School London United KingdomUCL Department of Primary Care & Population Health UCL Medical School London United KingdomMRC Integrative Epidemiology Unit at the University of Bristol United KingdomDepartment of Epidemiology and Public Health University College London London United KingdomDepartment of Epidemiology and Public Health University College London London United KingdomMRC Integrative Epidemiology Unit at the University of Bristol United KingdomPopulation Health Sciences Bristol Medical School University of Bristol United KingdomCardiometabolic Phenotyping Group Institute of Cardiovascular Science University College London London United KingdomMRC Clinical Trials Unit at UCL Institute of Clinical Trials & MethodologyUniversity College London London United KingdomFarr Institute of Health Informatics University College London London United KingdomFarr Institute of Health Informatics University College London London United KingdomMRC Clinical Trials Unit at UCL Institute of Clinical Trials & MethodologyUniversity College London London United KingdomInstitute of Cardiovascular Science University College London London United KingdomInstitute of Cardiovascular Science University College London London United KingdomMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USAInstitute of Cardiovascular Science University College London London United KingdomBackground We aimed at investigating the association of circulating fatty acids with coronary heart disease (CHD) and stroke risk. Methods and Results We conducted an individual‐participant data meta‐analysis of 5 UK‐based cohorts and 1 matched case‐control study. Fatty acids (ie, omega‐3 docosahexaenoic acid, omega‐6 linoleic acid, monounsaturated and saturated fatty acids) were measured at baseline using an automated high‐throughput serum nuclear magnetic resonance metabolomics platform. Data from 3022 incident CHD cases (13 104 controls) and 1606 incident stroke cases (13 369 controls) were included. Logistic regression was used to model the relation between fatty acids and odds of CHD and stroke, adjusting for demographic and lifestyle variables only (ie, minimally adjusted model) or with further adjustment for other fatty acids (ie, fully adjusted model). Although circulating docosahexaenoic acid, but not linoleic acid, was related to lower CHD risk in the fully adjusted model (odds ratio, 0.85; 95% CI, 0.76–0.95 per standard unit of docosahexaenoic acid), there was evidence of high between‐study heterogeneity and effect modification by study design. Stroke risk was consistently lower with increasing circulating linoleic acid (odds ratio for fully adjusted model, 0.82; 95% CI, 0.75–0.90). Circulating monounsaturated fatty acids were associated with higher CHD risk across all models and with stroke risk in the fully adjusted model (odds ratio, 1.22; 95% CI, 1.03–1.44). Saturated fatty acids were not related to increased CHD risk in the fully adjusted model (odds ratio, 0.94; 95% CI, 0.82–1.09), or stroke risk. Conclusions We found consistent evidence that linoleic acid was associated with decreased risk of stroke and that monounsaturated fatty acids were associated with increased risk of CHD. The different pattern between CHD and stroke in terms of fatty acids risk profile suggests future studies should be cautious about using composite events. Different study designs are needed to assess which, if any, of the associations observed is causal.https://www.ahajournals.org/doi/10.1161/JAHA.119.013131coronary artery diseaseepidemiologyfatty acidsstroke |
| spellingShingle | Maria Carolina Borges Amand Floriaan Schmidt Barbara Jefferis S. Goya Wannamethee Debbie A. Lawlor Mika Kivimaki Meena Kumari Tom R. Gaunt Yoav Ben‐Shlomo Therese Tillin Usha Menon Rui Providencia Caroline Dale Aleksandra Gentry‐Maharaj Alun Hughes Nish Chaturvedi Juan Pablo Casas Aroon D. Hingorani Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease coronary artery disease epidemiology fatty acids stroke |
| title | Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants |
| title_full | Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants |
| title_fullStr | Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants |
| title_full_unstemmed | Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants |
| title_short | Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants |
| title_sort | circulating fatty acids and risk of coronary heart disease and stroke individual participant data meta analysis in up to 16 126 participants |
| topic | coronary artery disease epidemiology fatty acids stroke |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.013131 |
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